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The Genetics of Male Infertility

  • Book
  • © 2007

Overview

Editors:
  1. Douglas T. Carrell

    1. Departments of Surgery (Urology), Obstetrics and Gynecology, and Physiology, University of Utah School of Medicine, Salt Lake City

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Table of contents (21 chapters)

  1. Front Matter

    Pages i-xv
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  2. Methods and Tools for the Study

    1. Front Matter

      Pages 2-2
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    2. The Genetics of Male Infertility in the Era of Genomics

      • Douglas T. Carrell
      Pages 3-27

    3. The Use of cDNA Libraries to Demonstrate a Linkage Between Transcription and Translation in Male Germ Cells

      • Norman B. Hecht
      Pages 29-35

    4. Considerations When Using Array Technologies for Male Factor Assessment

      • Adrian E. Platts, David J. Dix, Stephen A. Krawetz
      Pages 37-54

    5. Microarray Analysis of a Large Number of Single-Nucleotide Polymorphisms in Individual Human Spermatozoa

      • Honghua Li, Xiangfeng Cui, Danielle M. Greenawalt, Guohong Hu, Nyam-Osor Chimge, Sreemanta Pramanik et al.
      Pages 55-76

    6. Physiological and Proteomic Approaches to Understanding Human Sperm Function

      • Sarah J. Conner, Linda Lefièvre, Jackson Kirkman-Brown, Gisela S. M. Machado-Oliveira, Frank Michelangeli, Stephen J. Publicover et al.
      Pages 77-97

    7. Genetics of Idiopathic Male Infertility

      • Angshumoy Roy, Yi-Nan Lin, Martin M. Matzuk
      Pages 99-111

  3. Meiosis and Errors of Meiosis

    1. Front Matter

      Pages 113-113
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    2. The Immunocytogenetics of Human Male Meiosis

      • Daniel Topping, Petrice Brown, Terry Hassold
      Pages 115-128

    3. The Clinical Relevance of Sperm Aneuploidy

      • Renee H. Martin
      Pages 129-144

    4. DNA Repair Genes and Genomic Instability in Severe Male Factor Infertility

      • Francesca K. E. Gordon, Dolores J. Lamb
      Pages 145-163

  4. The Y Chromosome, Development Spermatogenesis, and Sperm Maturation

    1. Front Matter

      Pages 165-165
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    2. Germ Cell-Specific Genes and Posttranscriptional Regulation in the Testis

      • Mark S. Fox, Renee A. Reijo Pera
      Pages 167-184

    3. The Genetics of Cryptorchidism

      • Alexander I. Agoulnik, Shu Feng
      Pages 185-198

    4. The Chromatoid Body and microRNA Pathways in Male Germ Cells

      • Martti Parvinen, Noora Kotaja, Durga Prasad Mishra, Paolo Sassone-Corsi
      Pages 199-209

    5. Sperm Maturation in the Epididymis

      • Gail A. Cornwall, Hans H. von Horsten
      Pages 211-231

  5. Clinical Applications of the Study of the Genetics of Male Infertility

    1. Front Matter

      Pages 232-232
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    2. The Structure of the Y Chromosome and Its Role in Male Infertility

      • Leslie Ayensu-Coker, Colin Bishop, Jan Rohozinski
      Pages 233-238

    3. Y Chromosome Microdeletions and Haplotypes

      • Ken McElreavey, Celia Ravel, Brahim El Houate, Jacqueline Mandelbaum, Sandra Chantot-Bastaraud, Jean-Pierre Siffroi
      Pages 239-249
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Keywords

About this book

Infertility is a common and severe health problem affecting roughly 7% of the male population. It is likely that the majority of those patients have genetic abnormalities that are the cause of their infertility. In The Genetics of Male Infertility, twenty-one researchers and clinicians review the study of the genetics of male infertility, the tools available in the laboratory and clinic, the current state of knowledge, and the future of research and translation into clinical diagnostics and treatments.
This volume gives special attention to the significant technological advances in the treatment of male infertility, including intracytoplasmic injection (ICSI) in conjunction with in vitro fertilization (IVF). In addition, new tools discussed include in vitro methodologies, in silico technologies, and new model organisms.
Providing a review of our current understanding of genetic causes of male infertility, The Genetics of Male Infertility serves as a guide to evidence-based clinical applications, and a preview of future possibilities.

Editors and Affiliations

  • Departments of Surgery (Urology), Obstetrics and Gynecology, and Physiology, University of Utah School of Medicine, Salt Lake City

    Douglas T. Carrell

Bibliographic Information

  • Book Title: The Genetics of Male Infertility

  • Editors: Douglas T. Carrell

  • DOI: https://doi.org/10.1007/978-1-59745-176-5

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Humana Press 2007

  • Hardcover ISBN: 978-1-58829-863-8Published: 28 November 2006

  • Softcover ISBN: 978-1-61737-811-9Published: 19 January 2011

  • eBook ISBN: 978-1-59745-176-5Published: 08 November 2007

  • Edition Number: 1

  • Number of Pages: XVI, 337

  • Number of Illustrations: 47 b/w illustrations

  • Topics: Human Genetics, Urology

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