Overview
- Editors:
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Hydar Ali
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Department of Pathology, School of Dental Medicine, The University of Pennsylvania, Philadelphia
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Bodduluri Haribabu
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Department of Microbiology and Immunology, James Graham Brown Cancer Center, University of Louisville, Louisville
- fully updated and expanded second edition
- state-of-the-art methods
- Methods in Molecular Biology™ series format
- Includes supplementary material: sn.pub/extras
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Table of contents (21 protocols)
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Overviews
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- Kanchana Natarajan, Bradford C. Berk
Pages 51-77
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Specific Topics
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Front Matter
Pages 101-101
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Membrane Receptors and Signaling
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- Marcin Majka, Mariusz Z. Ratajczak
Pages 103-114
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- Zi-xuan Wang, James R. Broach, Stephen C. Peiper
Pages 115-127
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- Jean-Marc Navenot, Zi-xuan Wang, Stephen C. Peiper
Pages 129-139
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- Mario Mellado, Antonio Serrano, Carlos Mart’inez-A, José Miguel Rodríguez-Frade
Pages 141-158
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- Venkatakrishna R. Jala, Bodduluri Haribabu
Pages 159-166
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Lipid Raft and Caveolae in Transmembrane Signaling
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- Kathleen Boesze-Battaglia
Pages 169-179
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- Rennolds S. Ostrom, Paul A. Insel
Pages 181-190
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Protein—Protein Interaction in Transmembrane Signaling
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- Tarik Issad, Ralf Jockers
Pages 195-209
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- Kelly L. Jordan-Sciutto, Marshall B. Montgomery
Pages 211-231
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- Hyun Woo Lee, Jaewon Ko, Eunjoon Kim
Pages 233-244
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Rho Guanosine Triphosphatases and Reconstitution of Signaling Complexes
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- Ritu Garg, Anne J. Ridley
Pages 257-267
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- Mary Stofega, Celine DerMardirossian, Gary M. Bokoch
Pages 269-279
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- Shankar S. Iyer, David J. Kusner
Pages 281-298
About this book
The previous edition of Transmembrane Signaling Protocols was published in 1998. Since then the human genome has been completely sequenced and new methods have been developed for the use of microarrays and proteomics to analyze global changes in gene expression and protein profiles. These advances have increased our ability to understand transmembrane signaling processes in much greater detail. They have also simultaneously enhanced our ability to determine the role of a large number of newly identified molecules in signaling events. In addition, novel video microscopy methods have been developed to image transmembrane signaling events in live cells in real time. In view of these major advances, it is time to update the previous edition. Because of the success of that volume, we have chosen to keep the essential character of the book intact. Introductory chapters from experts have been included to provide overall perspective and an overview of recent advances in signal transduction pathways. The individual chapters now include comp- hensive detailed methods, studies in genetically tractable systems, fluorescence microscopy in live single cells, ex vivo analysis of primary cells from tra- genic mice, as well as genomic and proteomic approaches to the analysis of transmembrane signaling events. We would like to express our deep gratitude to the coauthors of this publi- tion. We hope that Transmembrane Signaling Protocols, Second Edition will serve as a valuable resource for future progress in the study of signal transd- tion pathways.
Reviews
From Reviews of the First Edition...
"...well put together...covers a range of signaling protocols and would serve well as a reference for what methods are currently being used in the field." -Molecular Biotechnology
"...a good book for a non-specialist entering the field and specialists looking for well-described techniques." -Microbiology Today
Editors and Affiliations
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Department of Pathology, School of Dental Medicine, The University of Pennsylvania, Philadelphia
Hydar Ali
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Department of Microbiology and Immunology, James Graham Brown Cancer Center, University of Louisville, Louisville
Bodduluri Haribabu
