Cancer Drug Resistance

1. Front Matter

   Pages i-xvi

   PDF

2. Physiological Resistance

   1. Front Matter

      Pages 1-1

      PDF

   2. The Cycle Between Angiogenesis, Perfusion, and Hypoxia in Tumors

      • Mark W. Dewhirst, Yiting Cao, Benjamin Moeller, Chuan-Yuan Li

      Pages 3-19

   3. Influence of Tumor pH on Therapeutic Response

      • Chang W. Song, Robert Griffin, Heon Joo Park

      Pages 21-42

   4. Tumor Oxygenation and Treatment Response

      • Sarah Jane Lunt, Richard P. Hill

      Pages 43-66

   5. Oncogenes and Tumor Suppressor Genes in Therapeutic Resistance

      • Janusz W. Rak, Brenda Coomber, Joanne L. Yu

      Pages 67-103

   6. PET Imaging of Response and Resistance to Cancer Therapy

      • David A. Mankoff, Kenneth A. Krohn

      Pages 105-122

3. Biological Resistance

   1. Front Matter

      Pages 123-123

      PDF

   2. Cancer Stem Cells Implications for Development of More Effective Therapies

      • Ilia Mantle, Gabriela Dontu, Suling Liu, Max S. Wicha

      Pages 125-136

   3. Therapeutic Resistance in Leukemia

      • William R. Waud

      Pages 137-150

   4. Tumor Site Implantation and Animal Model Selection in Oncology

      • Anibal A. Arjona, Enrique Alvarez

      Pages 151-159

   5. In Vivo Resistance

      • Beverly A. Teicher

      Pages 161-179

   6. Characteristics of the Metastatic Phenotype

      • Vladislava O. Melnikova, Menashe Bar-Eli

      Pages 181-200

   7. The Microenvironment and Drug Resistance

      • Patrice J. Morin

      Pages 201-210

4. Biochemical Resistance

   1. Front Matter

      Pages 211-211

      PDF

   2. Glutathione and Glutathione S-Transferases in Drug Resistance

      • Victoria J. Findlay, Danyelle M. Townsend, Kenneth D. Tew

      Pages 213-221

   3. Metallothioneins in Drug Resistance

      • Faiyaz Notta, D. James Koropatnick

      Pages 223-239

   4. Molecular Determinants of Intrinsic Multidrug Resistance in Cancer Cells and Tumors

      • Elena Monti

      Pages 241-260

   5. New and Revised Concepts in Multidrug Resistance

      • Susan E. Bates, John Deeken, Chaohong Fan, Robert W. Robey

      Pages 261-282

   6. Cisplatin Resistance

      • Zahid H. Siddik

      Pages 283-307

Leading experts summarize and synthesize the latest discoveries concerning the changes that occur in tumor cells as they develop resistance to anticancer drugs, and suggest new approaches to preventing and overcoming it. The authors review physiological resistance based upon tumor architecture, cellular resistance based on drug transport, epigenetic changes that neutralize or bypass drug cytotoxicity, and genetic changes that alter drug target molecules by decreasing or eliminating drug binding and efficacy. Highlights include new insights into resistance to antiangiogenic therapies, oncogenes and tumor suppressor genes in therapeutic resistance, cancer stem cells, and the development of more effective therapies. There are also new findings on tumor immune escape mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin.

• angiogenesis
• cancer
• cytotoxicity
• drug
• drug resistance
• hormones
• imaging
• immunotherapy
• leukemia
• melanoma
• oncogenes
• pharmacology
• resistance
• toxicity
• tumor

"...a resource to scientists of diverse specialties with interests relating to the repsonse of malignant disease to current and experimental therapies." - Neoplasma

"...an excellent book that is appropriate for scientists and clinicians with an interest in the basis of anticancer drug resistance." -Doody's Book Review, Weighted Numberical Score: 90 - 4 Stars!

• Genzyme Corporation, Framingham

  Beverly A. Teicher

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