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Natural Products

Drug Discovery and Therapeutic Medicine

  • Book
  • © 2005

Overview

Editors:
  1. Lixin Zhang

    1. Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China
      SynerZ Pharmaceuticals Inc., Lexington

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    You can also search for this editor in PubMed   Google Scholar

  2. Arnold L. Demain

    1. Charles A. Dana Research Institute (R.I.S.E.), Drew University, Madison

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    You can also search for this editor in PubMed   Google Scholar

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-xiv
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  2. Fundamental Issues Related to Natural Product-Based Drug Delivery

    1. Front Matter

      Pages 1-1
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    2. Natural Products and Drug Discovery

      • Arnold L. Demain, Lixin Zhang
      Pages 3-29

  3. Strategies

    1. Front Matter

      Pages 31-31
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    2. Integrated Approaches for Discovering Novel Drugs From Microbial Natural Products

      • Lixin Zhang
      Pages 33-55

    3. Automated Analyses of HPLC Profiles of Microbial Extracts

      • José R. Tormo, Juan B. García
      Pages 57-75

    4. Manipulating Microbial Metabolites for Drug Discovery and Production

      • C. Richard Hutchinson
      Pages 77-93

    5. Improving Drug Discovery From Microorganisms

      • Chris M. Farnet, Emmanuel Zazopoulos
      Pages 95-106

    6. Developments in Strain Improvement Technology

      • Stephen B. del Cardayré
      Pages 107-125

  4. Specific Groups of Drugs

    1. Front Matter

      Pages 127-127
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    2. The Discovery of Anticancer Drugs From Natural Sources

      • David J. Newman, Gordon M. Cragg
      Pages 129-168

    3. Case Studies in Natural-Product Optimization

      • Jian Hong, Shu-Hui Chen
      Pages 169-196

    4. Terpenoids As Therapeutic Drugs and Pharmaceutical Agents

      • Guangyi Wang, Weiping Tang, Robert R. Bidigare
      Pages 197-227

    5. Challenges and Opportunities in the Chinese Herbal Drug Industry

      • Wei Jia, Lixin Zhang
      Pages 229-250

    6. Arsenic Trioxide and Leukemia

      • Guo-Qiang Chen, Qiong Wang, Hua Yan, Zhu Chen
      Pages 251-272

  5. Microbial Diversity

    1. Front Matter

      Pages 273-273
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    2. New Methods to Access Microbial Diversity for Small Molecule Discovery

      • Karsten Zengler, Ashish Paradkar, Martin Keller
      Pages 275-293

    3. Accessing the Genomes of Uncultivated Microbes for Novel Natural Products

      • Asuncion Martinez, Joern Hopke, Ian A. MacNeil, Marcia S. Osburne
      Pages 295-312

  6. Specific Sources

    1. Front Matter

      Pages 313-313
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    2. New Natural-Product Diversity From Marine Actinomycetes

      • Paul R. Jensen, William Fenical
      Pages 315-328
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Keywords

About this book

A fresh examination of the past successes of natural products as medicines and their new future from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discoveries, to microbial diversity, to specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious.

Reviews

From the reviews:

"Natural Products, Drug Discovery and Therapeutic Medicine timely shares the experience of renowned scientist from academy and industry working in the field. … a very comprehensive tool that will help everybody interested in the discovery of natural products. I highly recommend this book for those who want to understand the potential of drug development from natural products in the light of modern knowledge and technology as well as for individuals who want to understand history of pass successes in drug discovery from natural products." (Sonia Mesia-Vela, Phytomedicine, Vol. 13, 2006)

Editors and Affiliations

  • Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China

    Lixin Zhang

  • SynerZ Pharmaceuticals Inc., Lexington

    Lixin Zhang

  • Charles A. Dana Research Institute (R.I.S.E.), Drew University, Madison

    Arnold L. Demain

Bibliographic Information

  • Book Title: Natural Products

  • Book Subtitle: Drug Discovery and Therapeutic Medicine

  • Editors: Lixin Zhang, Arnold L. Demain

  • DOI: https://doi.org/10.1007/978-1-59259-976-9

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Humana Press 2005

  • Hardcover ISBN: 978-1-58829-383-1Published: 15 April 2005

  • Softcover ISBN: 978-1-61737-533-0Published: 05 November 2010

  • eBook ISBN: 978-1-59259-976-9Published: 17 November 2007

  • Edition Number: 1

  • Number of Pages: XIV, 386

  • Number of Illustrations: 184 b/w illustrations

  • Topics: Pharmacy

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