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Vaccine Adjuvants

  • Book
  • © 2006

Overview

Editors:
  1. Charles J. Hackett

    1. Division of Allergy, Immunology, and Transplantation National Institute of Allergy and Infectious Diseases, NIH, Bethesda

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  2. Donald A. Harn

    1. Department of Immunology and Infectious Disease, Harvard School of Public Health, Boston

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Infectious Disease (ID)

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-xi
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  2. Microbial Pathogenesis and the Discovery of Toll-Like Receptor Function

    • Bruce Beutler
    Pages 1-24

  3. Dendritic Cells

    • Bali Pulendran, Anshu Agrawal, Stephanie Dillon, Sudhanshu Agrawal
    Pages 25-38

  4. Achieving Transcriptional Specificity in NF-κB-Dependent Inflammatory Gene Expression

    • Gioacchino Natoli
    Pages 39-48

  5. Adjuvants and the Initiation of T-Cell Responses

    • Matthew F. Mescher, Julie M. Curtsinger, Marc Jenkins
    Pages 49-67

  6. Mechanism for Recognition of CpG DNA

    • Kiyoshi Takeda, Hiroaki Hemmi, Shizuo Akira
    Pages 69-86

  7. CpG ODN As a Th1 Immune Enhancer for Prophylactic and Therapeutic Vaccines

    • Arthur M. Krieg, Heather L. Davis
    Pages 87-110

  8. Modified Bacterial Toxins

    • Ed C. Lavelle, Olive Leavy, Kingston H. G. Mills
    Pages 111-153

  9. Glycosylphosphatidylinositol Anchors As Natural Immunological Adjuvants Derived From Protozoan Parasites

    • Ricardo T. Gazzinelli, Catherine Ropert, Igor C. Almeida, João S. Silva, Marco A. Campos
    Pages 155-175

  10. The Immunomodulatory Glycan LNFPIII/Lewis X Functions As a Potent Adjuvant for Protein Antigens

    • Mitsuhiro Okano, Kazunori Nishizaki, Akram Da’dara, Paul Thomas, Michele Carter, Donald A. Harn Jr.
    Pages 177-191

  11. Immune and Antiviral Effects of the Synthetic Immunomodulator Murabutide

    • George M. Bahr
    Pages 193-219

  12. Effects of QS-21 on Innate and Adaptive Immune Responses

    • Charlotte Read Kensil, Gui Liu, Christine Anderson, James Storey
    Pages 221-234

  13. Monophosphoryl Lipid A and Synthetic Lipid A Mimetics As TLR4-Based Adjuvants and Immunomodulators

    • Jory Baldridge, Kent Myers, David Johnson, David Persing, Christopher Cluff, Robert Hershberg
    Pages 235-255

  14. Microparticles and DNA Vaccines

    • Kimberly Denis-Mize, Manmohan Singh, Derek T. O’Hagan, Jeffrey B. Ulmer, John J. Donnelly
    Pages 257-270

  15. Back Matter

    Pages 271-284
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Keywords

About this book

A cutting-edge review of the major research areas of adjuvant discovery, design, development, and use. The authors lay down a rational basis for vaccine adjuvant function and analyze a number of significantly distinct adjuvant-active molecules to illuminate the principles of their function and use. The focus is on specific receptor-ligand interactions, including the molecular features needed for a compound to possess adjuvant activity. The critical interface zone between the innate and adaptive immune systems is also analyzed to show how adjuvants exert their effects on T- and B-cell activation. Additional chapters address the possibility of tailoring adjuvants to yield optimally safe and effective responses.

Reviews

From the reviews:

"This book describes in detail major advances in vaccine adjuvant discovery, design, development, and use. … fills a void in our knowledge of vaccine adjuvants, providing one authoritative text source for the latest information on this topic. The book meets the authors’ objectives superbly. … it could serve as a reference for students, residents, and practitioners, particularly in the fields of infectious diseases and immunology. … It will serve as a valuable reference for those interested in this field." (Archana NMI Chatterjee, Doody’s Review Service, July, 2006)

Editors and Affiliations

  • Division of Allergy, Immunology, and Transplantation National Institute of Allergy and Infectious Diseases, NIH, Bethesda

    Charles J. Hackett

  • Department of Immunology and Infectious Disease, Harvard School of Public Health, Boston

    Donald A. Harn

Bibliographic Information

  • Book Title: Vaccine Adjuvants

  • Editors: Charles J. Hackett, Donald A. Harn

  • Series Title: Infectious Disease

  • DOI: https://doi.org/10.1007/978-1-59259-970-7

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Humana Press 2006

  • Hardcover ISBN: 978-0-89603-892-9Published: 01 December 2005

  • Softcover ISBN: 978-1-61737-240-7Published: 09 December 2010

  • eBook ISBN: 978-1-59259-970-7Published: 05 November 2007

  • Edition Number: 1

  • Number of Pages: XII, 284

  • Number of Illustrations: 28 b/w illustrations

  • Topics: Immunology

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