Drugs of Abuse

1. Front Matter

   Pages i-ix

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2. Historical Aspects of Drugs-of-Abuse Testing in the United States

   • Lawrence A. Reynolds

   Pages 1-10

3. Specimens for Drugs-of-Abuse Testing

   • Leo J. Kadehjian

   Pages 11-28

4. Drug-Testing Technologies and Applications

   • Jane S-C. Tsai, Grace L. Lin

   Pages 29-69

5. The Use of Nitrocellulose Membranes in Lateral-Flow Assays

   • Michael A. Mansfield

   Pages 71-85

6. Antibody-Label Conjugates in Lateral-Flow Assays

   • Paul Christopher, Nikki Robinson, Michael K. Shaw

   Pages 87-98

7. Lateral-Flow Assays

   • David Carlberg

   Pages 99-114

8. Oral-Fluid Drug Testing Using the Intercept® Device

   • R. Sam Niedbala, Keith W. Kardos

   Pages 115-131

9. Dräger DrugTest®

   • Stefan Steinmeyer, Rainer Polzius, Andreas Manns

   Pages 133-144

10. On-Site Oral-Fluid Drug Testing by Oratect®

    • Raphael C. Wong

    Pages 145-159

11. Saliva and Sweat Testing With Drugwipe®

    • Franz Aberl, Robert VanDine

    Pages 161-175

12. Hair Analysis in Drugs-of-Abuse Testing

    • Michael I. Schaffer, Virginia A. Hill

    Pages 177-200

13. Instrumented Urine Point-of-Collection Testing Using the eScreen® System

    • Murray Lappe

    Pages 201-215

14. Adulteration of Drugs-of-Abuse Specimens

    • Amitava Dasgupta

    Pages 217-232

15. Adulteration Detection by Intect® 7

    • Raphael C. Wong, Harley Y. Tse

    Pages 233-245

16. Drug Testing and the Criminal Justice System

    • John N. Marr

    Pages 247-258

17. Drugs-of-Abuse Testing

    • Alex Yil Fai Wong

    Pages 259-270

18. The Results of the Roadside Drug Testing Assessment Project

    • Alain G. Verstraete

    Pages 271-292

19. Trends in Drug Testing

    • Raphael C. Wong

    Pages 293-296

20. Back Matter

    Pages 297-305

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A comprehensive review of the science of drug testing in all its aspects, placing emphasis on technologies that use body fluids other than urine for determining the presence of drugs of abuse. The authors discuss the various body fluid specimens suitable for testing for illicit drugs-particularly saliva, sweat, and hair-describe the structural and manufacturing aspects of on-site testing devices based on lateral flow immunoassay, and detail the pitfalls of using these specimens. They also discuss in detail the problem of sample adulteration and its detection. Since oral fluid has the best potential of succeeding urine as the next matrix of choice for drug detection, four popular saliva testing devices are examined: Intercept®, the Drager Drug Test®, Oratect®, and Drugwipe. Political, social, and legal issues are also considered in articles on privacy, the use of drug testing in courts, and the problem of sample adulteration.

• antibody
• drug
• drugs of abuse
• research

From the reviews:

"This book discusses oral fluid, sweat, hair, and, to a lesser extent, urine as matrices for drugs of abuse testing. … the information is very detailed and specific. … Overall this text is well written and serves to provoke thoughts on where drugs of abuse testing is going in the future. While some of the information presented is directly related to forensic toxicology, the majority is more suited to end users of the immunoassay devices or those involved in workplace drug testing." (Maria Reid, Journal of the Canadian Society of Forensic Science, January, 2007)

• Branan Medical Corporation, Irvine

  Raphael C. Wong

• Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit

  Harley Y. Tse

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