Overview
- Editors:
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Edward D. Zanders
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CamBP Ltd., Cambridge, UK
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Table of contents (18 protocols)
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Protocols
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- Ana CecÃlia A. Roque, Geeta Gupta, Christopher R. Lowe
Pages 43-62
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- Aldo Jongejan, Chris de Graaf, Nico P. E. Vermeulen, Rob Leurs, Iwan J. P. de Esch
Pages 63-91
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- Kang Ryu, Steven Lin, Jun Shao, Jing Song, Min Chen, Wei Wang et al.
Pages 93-105
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- Michael B. Murphy, Sharon A. Doyle
Pages 123-130
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- Tatsuya Sawasaki, Mudeppa D. Gouda, Takayasu Kawasaki, Takafumi Tsuboi, Yuzuru Toscana, Kazuyuki Takai et al.
Pages 131-144
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- Yaeta Endo, Tatsuya Sawasaki
Pages 145-167
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- Jon Hoyt, Randall W. King
Pages 187-195
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- Jonathan M. Blackburn, Darren J. Hart
Pages 197-216
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- Judith Webster, David Oxley
Pages 227-240
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- Ruobing Wang, Shaoyi Liu, Dhaval Shah, Denong Wang
Pages 241-252
About this book
Chemical genomics is an exciting new field that aims to transform biolo- cal chemistry into a high-throughput industrialized process, much in the same way that molecular biology has been transformed by genomics. The inter- tion of small organic molecules with biological systems (mostly proteins) underpins drug discovery in the pharmaceutical and biotechnology industries, and therefore a volume of laboratory protocols that covers the key aspects of chemical genomics would be of use to biologists and chemists in these orga- zations. Academic scientists have been exploring the functions of proteins using small molecules as probes for many years and therefore would also b- efit from sharing ideas and laboratory procedures. Whatever the organizational backgrounds of the scientists involved, the challenges of extracting the ma- mum human benefit from genome sequencing projects remains considerable, and one where it is increasingly recognized that chemical genomics will play an important part. Chemical Genomics: Reviews and Protocols is divided into two sections, the first being a series of reviews to describe what chemical genomics is about and to set the scene for the protocol chapters. The subject is introduced by Paul Caron, who explains the various flavors of chemical genomics. This is f- lowed by Lutz Weber and Philip Dean who cover the interaction between organic molecules and protein targets from the different perspectives of la- ratory experimentation and in silico design. The protocols begin with the me- ods developed in Christopher Lowes’ laboratory (Roque et al.
Reviews
"...an elaborate combination of scientific background information with well-illustrated protocols...a prime reference book for scientists." -ChemBioChem
Editors and Affiliations
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CamBP Ltd., Cambridge, UK
Edward D. Zanders
