Angiogenesis and Direct Myocardial Revascularization

1. Front Matter

   Pages i-xi

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2. No-Option Patients

   • Roger J. Laham, Donald S. Baim

   Pages 1-17

3. Transcriptional Regulation of Angiogenesis

   • Peter Oettgen

   Pages 19-36

4. Preclinical Models and Experience to Date

   • Aysegul Yegin, Nicolas A. Chronos

   Pages 37-64

5. The Coronary Microcirculation and Angiogenesis

   • Pierre Voisine, Joanna J. Wykrzykowska, Munir Boodhwani, David G. Harrison, Roger J. Laham, Frank W. Sellke

   Pages 65-105

6. Local and Regional Vascular Delivery Strategies for Therapeutic Angiogenesis and Myogenesis

   • Erik T. Price, Alan C. Yeung, Mehrdad Rezaee

   Pages 107-141

7. Imaging Angiogenesis

   • Justin D. Pearlman

   Pages 143-184

8. Myocardial Angiogenesis

   • Kwang Soo Cha, Robert S. Schwartz, Timothy D. Henry

   Pages 185-214

9. Gene Therapy for Angiogenesis in the Treatment of Cardiovascular and Peripheral Arterial Disease

   • Pinak B. Shah, Kapildeo Lotun, Douglas W. Losordo

   Pages 215-244

10. Therapeutic Angiogenesis in Peripheral Arterial Disease

    • Richard E. Waters, Brian H. Annex

    Pages 245-259

11. Bone Marrow Cell Transplantation for Myocardial Regeneration and Therapeutic Angiogenesis

    • Hung-Fat Tse, Pui-Yin Lee, Chu-Pak Lau

    Pages 261-281

12. Transplantation of Embryonic Stem Cells for Myocardial Regeneration and Angiogenesis

    • Yong-Fu Xiao, Jiang-Yong Min, James P. Morgan

    Pages 283-310

13. Skeletal Myoblast Transplantation for Cardiac Repair

    • Audrey Rosinberg, Jamal S. Rana, Roger J. Laham

    Pages 311-328

14. Transmyocardial Laser Revascularization

    • Keith A. Horvath

    Pages 329-348

15. Back Matter

    Pages 349-357

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An interdisciplinary panel of pioneers and opinion leaders review the basic, preclinical, clinical, and developmental pathways to new treatment strategies, such as therapeutic angiogenesis and myogenesis. The authors take advantage of new biological understanding, novel therapeutic targets, multiple available and well-studied therapeutic strategies, and the necessary imaging techniques to measure outcomes. Their in-depth discussions cover the identification of new therapeutic targets and pathways, the investigation of transcriptional factors, master switch molecules, cell-based approaches, chemokines, a better understanding of the effects of aging, endothelial dysfunction, and hypercholesterolemia in response to angiogenic stimuli. Highlights include examination of drug delivery problems, outcomes measure, stem therapy, high-risk interventions, development pathways, and future possibilities.

• Chemokine
• angiogenesis
• cardiovascular
• circulation
• drug
• drug delivery
• gene therapy
• transplantation

"This book masterfully and authoritatively blends expert opinion with quality scientific research to provide specialists with insight into current treatment options for end-stage ischemic patients and future possibilities." - Doody's Health Sciences Book Review Journal

"This book...summarizes this topic very well." -American Journal of Cardiology

• Beth Israel Deaconess Medical Center, Boston

  Roger J. Laham

• Brigham and Women’s Hospital, Boston

  Donald S. Baim

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