Inflammatory Disorders of the Nervous System

1. Front Matter

   Pages i-xiv

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2. Endothelial Cell-Leukocyte Interactions During CNS Inflammation

   • J. Steven Alexander, Alireza Minagar

   Pages 1-16

3. Multiple Sclerosis

   • Monica J. Carson, Crystal S. Anglen, Corinne Ploix

   Pages 17-40

4. Cytokines and Brain

   • Tammy Kielian, Paul D. Drew

   Pages 41-80

5. Chemokines and Central Nervous System Disorders

   • William J. Karpus

   Pages 81-90

6. Circulating Cell-Derived Microparticles in Thrombotic and Inflammatory Disorders

   • Wenche Jy, Lawrence L. Horstman, Joaquin J. Jimenez, Alireza Minagar, Yeon S. Ahn

   Pages 91-102

7. Multiple Sclerosis

   • William A. Sheremata

   Pages 103-131

8. Neuroprotective Effects of Interferon-β in Multiple Sclerosis

   • Fabrizio Giuliani, Rana Zabad, V. Wee Yong

   Pages 133-145

9. Acute Disseminated Encephalomyelitis

   • Sean J. Pittock, Dean M. Wingerchuk

   Pages 147-162

10. Ingested Type I Interferon in Experimental Autoimmune Encephalomyelitis

    • Staley A. Brod

    Pages 163-202

11. Neuromyelitis Optica

    • Dean M. Wingerchuk

    Pages 203-215

12. Transverse Myelitis

    • Chitra Krishnan, Adam I. Kaplin, Deepa M. Deshpande, Carlos A. Pardo, Douglas A. Kerr

    Pages 217-236

13. Optic Neuritis

    • Robert Zivadinov, Rohit Bakshi

    Pages 237-256

14. Central Nervous System Vasculitis

    • Shariq Mumtaz, Marjorie R. Fowler, Eduardo Gonzales-Toledo, Roger E. Kelley

    Pages 257-268

15. Neurosarcoidosis

    • Dakshinamurty Gullapalli, Lawrence H. Phillips II

    Pages 269-290

16. Neuropsychiatric SLE

    • Deborah Aleman-Hoey, Robin L. Brey

    Pages 291-304

17. Gene Expression in HIV-Associated Dementia

    • Paul Shapshak, Alireza Minagar, Elda M. Duran, Fabiana Ziegler, Wade Davis, Raman Seth et al.

    Pages 305-318

18. Human T-Lymphotropic Virus-Associated Neurological Disorders

    • Michael D. Lairmore, Bindhu Michael, Lee Silverman, Amrithraj Nair

    Pages 319-336

19. West Nile Virus Infection of the Nervous System

    • Douglas J. Lanska

    Pages 337-348

20. Back Matter

    Pages 349-362

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A cutting-edge review of the fundamental biological principles underlying the more common inflammatory disorders of the nervous system. The authors provide extensive updates on the latest findings concerning the mechanisms of inflammation and introduce such new concepts and methodologies as "endothelial and leukocyte microparticles" and "gene microarray technology" to help explain important links between the central nervous system (CNS) and general inflammatory processes. Among the diseases examined from an inflammatory perspective are multiple sclerosis, acute disseminated encephalomyelitis, optic neuritis, transverse myelitis, CNS vasculitis, neuropsychiatric systemic lupus erythematosis, Alzheimer's disease, and Parkinson's disease. The role of the immune system in neuroinflammation is also explored in such disorders as neurosarcoidois, HIV-Associated dementia, and HTLV-associated neurological disorders.

• Alzheimer
• Chemokine
• Nervous System
• Parkinson
• interferon

From the reviews:

"The objective of this book is to provide the readers with a highly detailed review of the basic principles of neuroinflammation and extensive updates of the latest findings on common neuroinflammatory disorders. … The treatment principles of the different inflammatory disorders are very well covered and up-to-date. This book can be of interest for the institutional library in order for doctors to look up specific details and treatment principles, and to enter deeply into neuroimmunological basics." (Orvar Eeg-Olofsson, European Journal of Paediatric Neurology, Vol. 11, June, 2007)

• Louisiana State University Health Science Center, Shreveport

  Alireza Minagar, J. Steven Alexander

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