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Molecular Neurosurgery with Targeted Toxins

  • Book
  • © 2005

Overview

Editors:
  1. Ronald G. Wiley

    1. Department of Neurology, Vanderbilt University School of Medicine, Nashville
      Department of Pharmacology, Vanderbilt University School of Medicine, Nashville
      Neurology Service, Veterans Affairs Tennessee Valley Healthcare System, Nashville

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    You can also search for this editor in PubMed   Google Scholar

  2. Douglas A. Lappi

    1. Advanced Targeting Systems, San Diego

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-xi
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  2. Introduction to Molecular Neurosurgery

    • Ronald G. Wiley, Douglas A. Lappi
    Pages 1-8

  3. Ribosome-Inactivating Proteins

    • Fiorenzo Stirpe
    Pages 9-29

  4. Biochemical, Physiological, and Behavioral Characterizations of the Cholinergic Basal Forebrain Lesion Produced by 192 IgG-Saporin

    • Jerene J. Waite
    Pages 31-58

  5. Basal Forebrain Cholinergic Lesion by 192 IgG-Saporin

    • Reinhard Schliebs
    Pages 59-86

  6. 192 IgG-Saporin-Induced Partial Cortical Cholinergic Deafferentation as a Model for Determining the Interactions Between Brain Aging and Neurodevelopmental Defects in the Cortical Cholinergic Input System

    • Martin Sarter, John P. Bruno
    Pages 87-100

  7. Exploring the Role of Acetylcholine in Primate Cognition Using Me20.4 IgG-Saporin

    • Rosalind M. Ridley, Harry F. Baker
    Pages 101-142

  8. Cortical Cholinergic Deafferentation Induces Aβ Deposition

    • Thomas G. Beach, D. G. Walker, P. E. Potter, L. I. Sue, S. Scott, K. J. Layne et al.
    Pages 143-180

  9. Chemical Dissection of Brain Glucoregulatory Circuitry

    • Sue Ritter, Thu T. Dinh, Kishor Bugarith, Dawna M. Salter
    Pages 181-218

  10. Cardiovascular Deficits After Lesions of C1 Adrenergic Neurons With a Saporin-Based Immunotoxin

    • Patrice G. Guyenet, Ruth L. Stornetta, Ann M. Schreihofer
    Pages 219-233

  11. Saporin Conjugates and Pain

    • Ronald G. Wiley, Douglas A. Lappi
    Pages 235-248

  12. The Use of Saporin Conjugates to Dissect Neurons Responsible for Sleep and Wakefulness

    • Carlos Blanco-Centurion, Dmitry Gerashchenko, Eric Murillo-Rodriguez, Frank Desarnaud, Priyattam J. Shiromani
    Pages 249-264

  13. Isolectin IB4-Mediated Cytotoxic Targeting of Sensory Neurons

    • Lucy Vulchanova, Christopher N. Honda
    Pages 265-291

  14. B Fragment of Cholera Toxin Conjugated to Saporin

    • Peter T. Ohara, Kanwarjit Kelley, Luc Jasmin
    Pages 293-306

  15. Back Matter

    Pages 307-311
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Keywords

About this book

Pioneers and leading researchers explain the theory and techniques of using targeted toxins experimentally. The highly successful use of the 192 IgG-saporin and ME20.4-saporin immunotoxins to lesion the cholinergic basal forebrain in order to model the behavior, anatomy, physiology, and pharmacology of Alzheimer's disease in animals is treated in detail to give a potential user the knowledge to comfortably use the techniques involved. The uses of important new lesioning agents such as anti-DBH-saporin immunotoxin to make remarkably selective lesions of catecholaminergic neurons, hypocretin-saporin that can produce narcoleptic animals, and other saporin conjugates, such as neuropeptide-saporin conjugates for pain research and cholera toxin B chain-saporin to produce a model of CNS demyelination are explained by experts in the field.

Reviews

"...a good purchase for most neuroscience and neurology libraries." - Doody's Health Science Book Review Journal

Editors and Affiliations

  • Department of Neurology, Vanderbilt University School of Medicine, Nashville

    Ronald G. Wiley

  • Department of Pharmacology, Vanderbilt University School of Medicine, Nashville

    Ronald G. Wiley

  • Neurology Service, Veterans Affairs Tennessee Valley Healthcare System, Nashville

    Ronald G. Wiley

  • Advanced Targeting Systems, San Diego

    Douglas A. Lappi

Bibliographic Information

  • Book Title: Molecular Neurosurgery with Targeted Toxins

  • Editors: Ronald G. Wiley, Douglas A. Lappi

  • DOI: https://doi.org/10.1007/978-1-59259-896-0

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Humana Press 2005

  • Hardcover ISBN: 978-1-58829-199-8Published: 22 March 2005

  • Softcover ISBN: 978-1-61737-420-3Published: 16 December 2010

  • eBook ISBN: 978-1-59259-896-0Published: 10 October 2007

  • Edition Number: 1

  • Number of Pages: XII, 312

  • Topics: Neurosurgery

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