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Chemosensitivity

Volume II: In Vivo Models, Imaging, and Molecular Regulators

  • Book
  • © 2005

Overview

Editors:
  1. Rosalyn D. Blumenthal

    1. Garden State Cancer Center, Belleville, USA

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Part of the book series: Methods in Molecular Medicine (MIMM, volume 111)

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Table of contents (26 protocols)

  1. Front Matter

    Pages i-xv
    Download chapter PDF

  2. Measurements of DNA Damage, Cell Death, and Regulators of Cytotoxicity

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. In Vitro Micronucleus Technique to Predict Chemosensitivity

      • Michael Fenech
      Pages 3-32

    3. Cell Cycle and Drug Sensitivity

      • Aslamuzzaman Kazi, Q. Ping Dou
      Pages 33-42

    4. TUNEL Assay as a Measure of Chemotherapy-Induced Apoptosis

      • Robert Wieder
      Pages 43-54

    5. Apoptosis Assessment by the DNA Diffusion Assay

      • Narendra P. Singh
      Pages 55-67

    6. PARP Cleavage and Caspase Activity to Assess Chemosensitivity

      • Alok C. Bharti, Yasunari Takada, Bharat B. Aggarwal
      Pages 69-78

    7. Diphenylamine Assay of DNA Fragmentation for Chemosensitivity Testing

      • Cicek Gercel-Taylor
      Pages 79-82

    8. Immunodetecting Members of the Bcl-2 Family of Proteins

      • Richard B. Lock, Kathleen M. Murphy
      Pages 83-96

    9. Correlation of Telomerase Activity and Telomere Length to Chemosensitivity

      • Yasuhiko Kiyozuka
      Pages 97-108

    10. Application of Silicon Sensor Technologies to Tumor Tissue In Vitro

      • Pedro Mestres-Ventura, Andrea Morguet, Anette Schofer, Michael Laue, Werner Schmidt
      Pages 109-125

    11. Overview of Tumor Cell Chemoresistance Mechanisms

      • Laura Gatti, Franco Zunino
      Pages 127-148

    12. Flow Cytometric Monitoring of Fluorescent Drug Retention and Efflux

      • Awtar Krishan, Ronald M. Hamelik
      Pages 149-166

    13. Flow Cytometric Measurement of Functional and Phenotypic P-Glycoprotein

      • Monica Pallis, Emma Das-Gupta
      Pages 167-181

    14. Measurement of Ceramide and Sphingolipid Metabolism in Tumors

      • David E. Modrak
      Pages 183-194
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Keywords

About this book

A state-of-the art collection of readily reproducible laboratory methods for assessing chemosensitivity in vitro and in vivo, and for assessing the parameters that modulate chemosensitivity in individual tumors. Chemosensitivity,Volume 2: In Vivo Models, Imaging, and Molecular Regulators contains cutting-edge protocols for classifying tumors into response categories and for customizing therapy to individuals. These readily reproducible techniques allow measurements of DNA damage, apoptotic cell death, and the molecular and cellular regulators of cytotoxicity, as well as in vivo animal modeling of chemosensitivity. A companion volume, Volume 1: In Vitro Assays contains in vitro and in vivo techniques to identify which new agents or combination of agents are effective for each type of tumor.

Editors and Affiliations

  • Garden State Cancer Center, Belleville, USA

    Rosalyn D. Blumenthal

Bibliographic Information

  • Book Title: Chemosensitivity

  • Book Subtitle: Volume II: In Vivo Models, Imaging, and Molecular Regulators

  • Editors: Rosalyn D. Blumenthal

  • Series Title: Methods in Molecular Medicine

  • DOI: https://doi.org/10.1385/1592598897

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Protocols

  • Copyright Information: Humana Press 2005

  • Hardcover ISBN: 978-1-58829-586-6Published: 14 February 2005

  • Softcover ISBN: 978-1-61737-660-3Published: 10 November 2010

  • eBook ISBN: 978-1-59259-889-2Published: 01 February 2008

  • Series ISSN: 1543-1894

  • Series E-ISSN: 1940-6037

  • Edition Number: 1

  • Number of Pages: XVIII, 442

  • Topics: Cancer Research

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