Brain Tumors

1. Front Matter

   Pages i-xi

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2. Epidemiology, Biology, Genetics, and Pathology

   1. Front Matter

      Pages 1-1

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   2. Epidemiology of Brain Tumors

      • Randa El-Zein, Melissa Bondy, Margaret Wrensch

      Pages 3-18

   3. Molecular Genetics of Tumors of the Central Nervous System

      • C. David James

      Pages 19-32

   4. Molecular Pathology of Nervous System Tumors

      • Catherine L. Nutt, Anat O. Stemmer-Rachamimov, J. Gregory Cairncross, David N. Louis

      Pages 33-53

   5. Genetic Modeling of Glioma Formation in Mice

      • Martin Begemann, Vinagolu K. Rajasekhar, Gregory N. Fuller, Eric C. Holland

      Pages 55-89

   6. Biology of Brain Metastasis

      • Minsoo Kang, Takamitsu Fujimaki, Seiji Yano, Isaiah J. Fidler

      Pages 91-106

   7. Analysis of Neural Precursor Cells in the Context of Origin of Brain Tumors, Their Treatment, and Repair of Treatment-Associated Damage

      • Mark Noble, Joerg Dietrich

      Pages 107-123

   8. Biology of Primitive Neuroectodermal Tumors

      • John R. Hill, Shoichiro Ohta, Mark A. Israel

      Pages 125-154

3. Mechanisms and Pathways

   1. Front Matter

      Pages 155-155

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   2. Molecular and Cellular Biology of the Blood-Brain Barrier and Its Characteristics in Brain Tumors

      • Helga E. de Vries, Lisette Montagne, Christine D. Dijkstra, Paul van der Valk

      Pages 157-174

   3. Immune Regulation in the Brain

      • Lois A. Lampson

      Pages 175-205

   4. Genetic Pathways in the Evolution of Gliomas

      • Hiroko Ohgaki, Paul Kleihues

      Pages 207-221

   5. DNA Damage and Repair in the Therapeutic Response of Tumors of the Central Nervous System

      • Henry S. Friedman, M. Eileen Dolan, Francis Ali-Osman

      Pages 223-235

   6. Role of Urokinase-Type Plasminogen Activator Receptor in Human Glioma Invasion

      • Sanjeeva Mohanam, Jasti S. Rao

      Pages 237-247

   7. Regulation of Cell-Cycle and Apoptosis in Human Brain Tumors

      • Juan Fueyo, Candelaria Gomez-Manzano, Timothy J. McDonnell

      Pages 249-264

4. Therapeutics

   1. Front Matter

      Pages 265-265

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   2. Systemic Chemotherapy for Metastatic Tumors of the Central Nervous System

      • Charles A. Conrad, W. K. Alfred Yung

      Pages 267-277

   3. Radiation Biology and Therapy of Tumors of the Central Nervous System

      • Nalin Gupta, John R. Fike, Penny K. Sneed, Philip J. Tofilon, Dennis F. Deen

      Pages 279-305

   4. Advances in the Management of Cerebral Metastases

      • Fadi Hanbali, Raymond Sawaya

      Pages 307-322

Exciting new developments and discoveries of the last two decades are beginning to shed light on the complex biology of brain tumors and are advancing our understa- ing of the cellular and molecular processes involved in their initiation, progression, and clinical and biological behavior. The disease process in brain tumors is quite complex and the resulting tumors are characterized by a high degree of biological and clinical diversity. Thus, despite the advances of the last two decades, prognosis for patients with malignant brain tumors remains abysmal. Significant progress in the diagnosis, treatment and, ultimately, prevention of these tumors will require both the timely h- nessing of the advances in basic and clinical brain tumor research, and a continuing concerted effort at increasing our understanding of brain tumor biology, in particular, the molecular genetic changes and perturbations of cellular pathways involved in brain oncogenesis and which drive the biological and clinical behavior of the tumors. Brain tumor diagnosis and prognosis, which is still largely based on histopathology and other clinical criteria, will, in the future, acquire a significant molecular component, with the incorporation of knowledge of genes that are mutated, over-expressed, deleted, silenced, or functionally altered in the tumors. Treatment strategies for brain tumors, rather than being empirical, will be rationally developed based on an understanding of the cellular and molecular mechanisms and targets that have been activated, suppressed, or otherwise altered.

• Nervous System
• apoptosis
• classification
• histopathology
• imaging

"This is an important book for the shelves of neuroscience, neurology, neurosurgery, and oncology departments. It's well worth the price." - Doody's Health Sciences Book Review Journal

"This book contains a welcome compilation of the known genetic reference with a good description of each abnormality." - The New England Journal of Medicine

"...this book is simply indispensable and should be a significant component for all individuals associated with either biology or treatment of gliomas...a thoroughly comprehensive, up-to-date, and timely review... ." - J. Neurosurg

• Department of Surgery, Duke University Medical Center, Durham

  Francis Ali-Osman

• Comprehensive Cancer Center, Duke University Medical Center, Durham

  Francis Ali-Osman

Policies and ethics