Signal Transduction and the Gasotransmitters

1. Front Matter

   Pages i-xiv

   PDF

2. Gasotransmitters: Past, Present, and Future

   1. Front Matter

      Pages 1-1

      PDF

   2. The Evolution of Gasotransmitter Biology and Medicine

      • Rui Wang

      Pages 3-31

   3. Interactions Between Gasotransmitters

      • Ray J. Carson, Gunter Seyffarth, Rubina Mian, Helen Maddock

      Pages 33-55

3. The Emergence of the First Gasotransmitter: Nitric Oxide

   1. Front Matter

      Pages 57-57

      PDF

   2. Nitric Oxide

      • Chris R. Triggle, Hong Ding, Ella S. M. Ng, Anthie Ellis

      Pages 59-94

   3. Chemical Interaction of Nitric Oxide With Protein Thiols

      • Allan Doctor, Benjamin M. Gaston

      Pages 95-107

   4. Nitric Oxide and Adenosine Triphosphate-Sensitive Potassium Channels

      • Shoji Sanada, Jiyoong Kim, Masafumi Kitakaze

      Pages 109-122

   5. Interaction of Nitric Oxide and Related Radical Species With KCa Channels

      • Yanping Liu, David D. Gutterman

      Pages 123-136

   6. Nitric Oxide and Voltage-Gated Ca2+ Channels

      • Claudio Grassi, Marcello D’Ascenzo, Gian Battista Azzena

      Pages 137-155

   7. Interactions of Nitric Oxide and Cardiac Ion Channels

      • Zhao Zhang, Kathryn A. Glatter, Nipavan Chiamvimonvat

      Pages 157-168

   8. S-Nitrosylation of Cyclic Nucleotide-Gated Channels

      • Marie-Christine Broillet

      Pages 169-183

4. Story of a Silent Killer: The Resurgence of Carbon Monoxide as the Second Gasotransmitter

   1. Front Matter

      Pages 185-185

      PDF

   2. Synthesis and Metabolism of Carbon Monoxide

      • Stefan W. Ryter, Augustine M. K. Choi

      Pages 187-203

   3. Interaction of Carbon Monoxide With K+ Channels in Vascular Smooth Muscle Cells

      • Rui Wang

      Pages 205-218

   4. Modulation of Multiple Types of Ion Channels by Carbon Monoxide in Nonvascular Tissues and Cells

      • Rui Wang

      Pages 219-230

   5. The Molecular Mechanisms Underlying the Effects of Carbon Monoxide on Calcium-Activated K+ Channels

      • Lingyun Wu

      Pages 231-247

   6. Carbon Monoxide and Signal Transduction Pathways

      • Patty J. Lee, Leo E. Otterbein

      Pages 249-258

   7. Carbon Monoxide-Induced Alterations in the Expression of KCa Channels in Pulmonary Artery Smooth Muscle Cells

      • Eric Dubuis, Prem Kumar, Pierre Bonnet, Christophe Vandier

      Pages 259-272

5. Gas of the Rotten Egg: Hydrogen Sulfide as the Third Gasotransmitter

   1. Front Matter

      Pages 273-273

      PDF

Gasotransmitters-principally nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)-are endogenous signaling molecules that play a significant role in the biomedical, clinical, and health sciences, as well as in population health studies. In Signal Transduction and the Gasotransmitters: NO, CO, and H2S in Biology and Medicine, a panel of distinguished researchers and clinicians review the biological and biomedical aspects of gasotransmitters, emphasizing their signaling transduction mechanisms in general, and ion channel regulation in particular. The authors discuss the endogeneous metabolism and regulation of gasotransmitters, their toxicological profiles and biological actions, and their interactions in terms of their production and effects. The physiological roles of NO, CO, and H2S in the regulation of the cardiovascular, neuronal, and gastrointestinal systems, as well as of cell metabolism, are also reviewed, along with the interaction of the gastrotransmitters with KATP,KCa voltage-gated Ca2+, voltage-gated Na+, and cyclic nucleotide-gated ion channels. Included in the array of different mechanisms for the interaction of NO, CO, and H2S are channel phosphorylation, S-nitrosylation, carboxylation, sulfuration, and altered cellular redox status. The authors also offer guidance and suggestions for exploring and further characterizing other still unknown gasotransmitters.
Authoritative and comprehensive, Signal Transduction and the Gasotransmitters: NO, CO, and H2S in Biology and Medicine offers clinical scientists and physicians not only a deeper understanding, but also a cutting-edge review, of the critically important field of gasotransmitter biology and medicine.

• ATP
• Calcium
• Nucleotide
• biology
• cell
• environment
• metabolism
• protein
• synthesis
• tissue

From the foreword...
"...a paradigm-shifting assessment of the new category of transmitters, the gasotransmitters."
-Bruce McManus, MD, PhD, FRSC, Canadian Institutes of Health Research

"...well-written...the account by Sanada and colleagues is particularly interesting on cardio protection and ischeamic preconditioning...this book should be of interest to both specialist researchers as well as members of the wider scientific commuity." -BTS Newsletters

"...an excellent source of references for signal transduction mechanisms underlying he physiological functions of NO, CO, and H2S." - British Journal of Anesthesiology

• Department of Physiology, University of Saskatchewan, Saskatoon, Canada

  Rui Wang

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