Overview
- Editors:
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Axel H. Schönthal
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Department of Molecular Microbiology and Immunology and K. Norris Jr. Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles
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Table of contents (14 protocols)
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Reviews of Checkpoint Controls, Their Involvement in the Development of Cancer, and Approaches to Their Investigation
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- George R. Stark, William R. Taylor
Pages 51-82
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- P. Todd Stukenberg, Daniel J. Burke
Pages 83-98
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- Bipin C. Dash, Wafik S. El-Deiry
Pages 99-161
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Analyzing Checkpoint Controls in Diverse Model Systems
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Front Matter
Pages 163-163
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- Xingzhi Xu, David F. Stern
Pages 165-174
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- Sandra Pavey, Brian G. Gabrielli
Pages 175-183
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- Chu-Xia Deng, Xiaoling Xu
Pages 185-200
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- Vincenzo Costanzo, Kirsten Robertson, Jean Gautier
Pages 213-227
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- Dongmin Kang, Jim Wong, Guowei Fang
Pages 229-243
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- Burnley Jaklevic, Amanda Purdy, Tin Tin Su
Pages 245-256
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- Anton Gartner, Amy J. MacQueen, Anne M. Villeneuve
Pages 257-274
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- Christopher M. Yellman, Daniel J. Burke
Pages 275-290
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- Catherine M. Green, Noel F. Lowndes
Pages 291-306
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Back Matter
Pages 307-318
About this book
Intracellular checkpoint controls constitute a network of signal transd- tion pathways that protect cells from external stresses and internal errors. Ext- nal stresses can be generated by the continuous assault of DNA-damaging agents, such as environmental mutagens, ultraviolet (UV) light, ionizing radiation, or the reactive oxygen species that can arise during normal cellular metabolism. In response to any of these assaults on the integrity of the genome, the activation of the network of checkpoint control pathways can lead to diverse cellular responses, such as cell cycle arrest, DNA repair, or elimination of the cell by cell death (apoptosis) if the damage cannot be repaired. Moreover, internal errors can occur during the highly orchestrated replication of the cellular genome and its distribution into daughter cells. Here, the temporal order of these cell cycle events must be strictly enforced—for example, to ensure that DNA replication is c- plete and occurs only once before cell division, or to monitor mitotic spindle assembly, and to prevent exit from mitosis until chromosome segregation has been completed. Thus, well functioning checkpoint mechanisms are central to the maintenance of genomic integrity and the basic viability of cells and, the- fore, are essential for proper development and survival. The importance of proper functioning of checkpoints becomes plainly obvious under conditions in which this control network malfunctions and fails. Depending on the severity and timing, failure of this machinery can lead to embryonic lethality, genetic diseases, and cancer.
Editors and Affiliations
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Department of Molecular Microbiology and Immunology and K. Norris Jr. Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles
Axel H. Schönthal
