Overview
- Editors:
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Eric T. Fung
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Ciphergen Biosystems Inc., Fremont
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Table of contents (23 protocols)
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- Hendrik Weiner, Thomas Faupel, Konrad Büssow
Pages 1-13
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- Michele Gilbert, Todd C. Edwards, Joanna S. Albala
Pages 15-23
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- Brian B. Haab, Heping Zhou
Pages 33-45
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- Alexei Kurakin, Susan Wu, Dale E. Bredesen
Pages 47-60
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- Petra Pavlickova, Hubert Hug
Pages 73-83
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- Rina Y. P. Lue, Grace Y. J. Chen, Qing Zhu, Marie-Laure Lesaicherre, Shao Q. Yao
Pages 85-100
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- Helen Petach, Rachel Ostroff, Chad Greef, Gregory M. Husar
Pages 101-110
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- Philipp Angenendt, Jörn Glökler
Pages 123-134
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- Susan M. Varnum, Ronald L. Woodbury, Richard C. Zangar
Pages 161-172
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- Alexsandra Espejo, Mark T. Bedford
Pages 173-181
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- Sangpen Chamnongpol, Xianqiang Li
Pages 183-189
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- Mahesh Uttamchandani, Grace Y. J. Chen, Marie-Laure Lesaicherre, Shao Q. Yao
Pages 191-204
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- Vanitha Thulasiraman, Zheng Wang, Anjali Katrekar, Lee Lomas, Tai-Tung Yip
Pages 205-214
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About this book
Protein Arrays: Methods and Protocols is an introduction to protein array technology and its application to the multiplexed detection of proteins. Although protein array technology has some roots in gene array technology, it can only be described as a distant relative. Unlike DNA, with its established rules of base pairing, and therefore predictable biochemical behavior, proteins are rich with diversity. Proteins can be large or small, compact or extended, basic or acidic, hydrophobic or hydrophilic, and so on. Just as importantly, their behavior is determined by the environment in which they reside, and so the composition of the buffer in which experiments are performed has a dramatic impact on the outcome of the experiment. Thus, if the goal is to simultaneously measure the expression of a large number of proteins, these variables must be addressed. Not to be deterred, scientists have created a variety of solutions to successfully detect and ch- acterize multiple proteins simultaneously. It is the intent of this volume to introduce to the reader a set of technological solutions to the diversity problem as well as to provide the reader with some examples of practical applications of these technologies.
Reviews
"Diverse and highly practical...offers basic and clinical investigators a broad spectrum of approaches to the generation of protein arrays..." - Clinical Laboratory International
"...provides a broad spectrum of approaches for the generation, production and application of protein arrays." - BTi
Editors and Affiliations
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Ciphergen Biosystems Inc., Fremont
Eric T. Fung
