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Hematopoietic Growth Factors in Oncology

Basic Science and Clinical Therapeutics

  • Book
  • © 2004

Overview

Editors:
  1. George Morstyn

    1. Amgen, Australia, Pty. Ltd., Monash University, Australia

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    You can also search for this editor in PubMed   Google Scholar

  2. MaryAnn Foote

    1. Amgen Inc., Thousand Oaks, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. Graham J. Lieschke

    1. Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Melbourne, Australia

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Cancer Drug Discovery and Development (CDD&D)

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Table of contents (22 chapters)

  1. Front Matter

    Pages i-x
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  2. Basic Research

    1. Front Matter

      Pages 1-1
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    2. Introduction to Hematopoietic Growth Factors

      • George Morstyn, MaryAnn Foote
      Pages 3-10

    3. Animal Models of Hematopoietic Growth Factor Perturbations in Physiology and Pathology

      • Graham J. Lieschke
      Pages 11-44

    4. The Jak-Stat Pathway of Cytokine Signaling

      • Ben A. Croker, Nicos A. Nicola
      Pages 45-64

    5. Small-Molecule and Peptide Agonists

      • Ellen G. Laber, C. Glenn Begley
      Pages 65-80

  3. Hematopoietic Growth Factors

    1. Front Matter

      Pages 81-81
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    2. Granulocyte Colony-Stimulating Factor

      • Graham Molineux
      Pages 83-95

    3. Erythropoietic Factors

      • Steven Elliott, Anne C. Heatherington, MaryAnn Foote
      Pages 97-123

    4. Thrombopoietin Factors

      • David J. Kuter
      Pages 125-151

    5. Stem Cell Factor and Its Receptor, c-Kit

      • Keith E. Langley
      Pages 153-184

    6. Hematopoietic Growth Factors

      • Ann M. Farese, Thomas J. MacVittie
      Pages 185-207

  4. Use of Hematopoietic Growth Factors in Oncology

    1. Front Matter

      Pages 209-209
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    2. Commentary on the ASCO and ESMO Evidence-Based Clinical Practice Guidelines for the Use of Hematopoietic Colony-Stimulating Factors

      • Richard M. Fox
      Pages 211-217

    3. Neutropenia and the Problem of Fever and Infection in Patients With Cancer

      • David C. Dale
      Pages 219-233

    4. Thrombocytopenia and Platelet Transfusions in Patients With Cancer

      • Lawrence T. Goodnough
      Pages 235-247

    5. Hematopoietic Growth Factors in Lung Cancer

      • Johan F. Vansteenkiste, Christophe A. Dooms
      Pages 249-274

    6. Role of Hematopoietic Growth Factors As Adjuncts to the Treatment of Hodgkin’s and Non-Hodgkin’s Lymphomas

      • Marcie R. Tomblyn, Jane N. Winter
      Pages 275-284

    7. Use of Granulocyte Growth Factors in Breast Cancer

      • Eric D. Mininberg, Frankie Ann Holmes
      Pages 285-309

    8. Role of Cytokines in the Management of Chronic Lymphocytic Leukemia

      • Carol Ann Long
      Pages 311-332
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Keywords

About this book

Whether to promote platelet recovery or to ameliorate the complications of cancer and the side effects of chemotherapy, hematopoietic growth factors (HGFs) now account for more than $5 billion per year of the US health care budget. In Hematopoietic Growth Factors in Oncology: Basic Science and Clinical Therapeutics, leading oncologists, hematologists, and nephrologists comprehensively review the role of HGFs in clinical practice, explain the molecular basis of their effects, and consider potential future developments. The authors focus on the use of HGFs in oncology, describing their cutting-edge application to patients with lung cancer, Hodgkin's and non-Hodgkin's lymphoma, breast cancer, chronic lymphocytic leukemia, AIDS-related malignancies, myelodysplastic syndromes, and aplastic anemias. Among the HGFs described are granulocyte colony-stimulating factor, erythropoietc factors, thrombopoietic factors, and stem-cell factor and its receptor, c-kit. To complete their survey, the contributors also consider the safety and economic implications of HGFs and the future potential for HGF antagonists in oncology.
Comprehensive and up-to-date, Hematopoietic Growth Factors in Oncology: Basic Science and Clinical Practice offers an integrated survey of the role of HGFs in treating and preventing anemia, neutropenia, and thrombocytopenia in patients with malignant and nonmalignant diseases, along with fresh insights into drug development and how basic discoveries in this area can be optimally translated into clinical benefit.

Reviews

"Comprehensive and up-to-date...offers an integrated survey of the role of HGFs in treating and preventing anemia, neutropenia, and thrombotopenia in patients wit malignant diseases, along with fresh insights into drug development and how basic discoveries in this area can be optimally translated into clinical benefit." - Tumori

Editors and Affiliations

  • Amgen, Australia, Pty. Ltd., Monash University, Australia

    George Morstyn

  • Amgen Inc., Thousand Oaks, USA

    MaryAnn Foote

  • Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Melbourne, Australia

    Graham J. Lieschke

Bibliographic Information

  • Book Title: Hematopoietic Growth Factors in Oncology

  • Book Subtitle: Basic Science and Clinical Therapeutics

  • Editors: George Morstyn, MaryAnn Foote, Graham J. Lieschke

  • Series Title: Cancer Drug Discovery and Development

  • DOI: https://doi.org/10.1007/978-1-59259-747-5

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2004

  • Hardcover ISBN: 978-1-58829-302-2Published: 05 February 2004

  • Softcover ISBN: 978-1-4684-9847-9Published: 22 July 2012

  • eBook ISBN: 978-1-59259-747-5Published: 05 February 2004

  • Series ISSN: 2196-9906

  • Series E-ISSN: 2196-9914

  • Edition Number: 1

  • Number of Pages: X, 477

  • Topics: Hematology

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