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Toxicity Assessment Alternatives

Methods, Issues, Opportunities

  • Book
  • © 1999

Overview

Editors:
  1. Harry Salem

    1. Chemical Command, Aberdeen Proving Ground, US Army Soldier and Biological, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Sidney A. Katz

    1. Rutgers University, Camden, USA

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    You can also search for this editor in PubMed   Google Scholar

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Table of contents (24 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Recent Developments on Alternatives

    1. Front Matter

      Pages 1-1
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    2. Tissue Engineering

      • Edith R. Schwartz
      Pages 3-14

    3. Tissue Engineering

      • Kiki B. Hellman
      Pages 15-17

    4. Electrical Resistance Method for Measuring Volume Changes in Astrocytes

      • Michael Aschner
      Pages 19-33

    5. Cytotoxicity Profiles for a Series of Investigational Compounds Using Liver Slice Technology and Human-Derived Cell Cultures

      • Sanjeev Thohan, Ho Chung
      Pages 35-52

    6. Antagonistic Interaction of Sodium Arsenite and Lead Sulfate with UV Light on Sister Chromatid Exchanges in Human Peripheral Lymphocytes

      • Spiros P. Katsifis, Patrick L. Kinney
      Pages 53-61

    7. The Role of Upper Airway Heat and Water Vapor Exchange in Hygroscopic Aerosol Deposition in the Human Airway

      • Jonathan W. Kaufman
      Pages 63-70

    8. Moving Average Interpolation for Malathion LC50 Estimation on Dugesia tigrina

      • R. B. Worobec
      Pages 71-77

    9. Physiological Modeling of Benzo(a)pyrene Pharmacokinetics in the Rat

      • David Moir
      Pages 79-95

  3. Current Trends and Future Directions

    1. Front Matter

      Pages 97-97
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    2. Resources for Biomedical Research

      • Elaine Young
      Pages 99-102

  4. Mechanistically Based Test Methods as Alternatives

    1. Front Matter

      Pages 103-103
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    2. Endocrine Disruption in Wildlife

      • Richard Dickerson, Ronald Kendall Sr.
      Pages 105-114

    3. Mechanistic Animal-Replacement Approaches for Predicting Pharmacokinetics of Organic Chemicals

      • Patrick Poulin, Martin Beliveau, Kannan Krishnan
      Pages 115-139

  5. Use of Alternatives in Hazard Assessment Initiatives

    1. Front Matter

      Pages 141-141
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    2. Validation of the Cytosensor™ Microphysiometer for In Vitro Cytotoxicity Testing

      • R. J. Mioduszewski, C. J. Cao, M. E. Eldefrawi, A. T. Eldefrawi, D. E. Menking, J. J. Valdes
      Pages 143-153

    3. Sulfur Mustard Effects on Cell Yield Alter Viability Assessment in Normal Human Epidermal Keratinocytes

      • Janet Moser, Susan A. Kelly, Henry L. Meier
      Pages 155-163

    4. Development of Human Keratinocyte Colonies for Confocal Microscopy and for Study of Calcium Effects on Growth Differentiation and Sulfur Mustard Lesions

      • Robert J. Werrlein, Tracey A. Hamilton, Janna S. Madren-Whalley
      Pages 165-174

    5. Phosgene-Induced Calcium Changes in Pulmonary Artery Endothelial Cells

      • Robert J. Werrlein, Stephen D. Kirby, Janna S. Madren-Whalley
      Pages 175-183
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Keywords

About this book

Toxicity Assessment Alternatives: Methods, Issues, Opportunities contains a broad array of critical surveys, contributed by active and respected investigators, describing their research and offering updates on toxicity assessment alternatives, directions determined by current and future grant programs, opportunities for mechanistically based test methods to detect endocrine disruptor activity, the use of alternatives in the Department of Defense hazard assessment initiatives, and the issues and opportunities for validation and regulatory acceptance. Several of these advances make use oftransgenic models that reduce the time and cost of carcinogenicity testing. Others use tissue cultures for the assessment of endocrine disrupting chemicals. Cultures of human epidermal keratinocytes are applicable as models for sulfur mustard lesions, and in vitro protein denaturation is used as a chemical test for assessing the ocular and dermal irritation potential of cosmetic prod­ ucts. Molecular modeling is applied to explaining chemical toxicity. Commercially developed assay systems have undergone extensive evaluation by their manufacturers. Some of these await external valida­ tion, and others await acceptance by North American and European regulatory agencies. Toxicity Assessment Alternatives: Methods, Issues, Opportunities provides information from members of the scientific and regulatory communities on what has been achieved and what has been accepted in alternatives to animal testing.

Reviews

"The value of these methods is that they can provide alternatives to more expensive and politically sensitive animal testing methods. . .By focusing on the human keratinocyte cell system, the complex response to sulfur mustard provides an excellent case example of the value of these alternative methods, and in this, this book is unique in the field. "-Doody's Health Sciences Book Review Journal

"This book is an up-to-date description of what has been accomplished thus far in developing acceptable alternatives to classical animal toxicity assessment methods. It includes not only reviews about alternatives for animal testing as such (e.g., tissue cultures for dermal toxicity and endocrine disruptor assessment, in vitro protein denaturation to assess ocular and dermal irritation potential of chemicals, and validation of alternative tests), it also reports on increasing testing efficiency (e.g., trans-genic models that reduce time and cost of carcinogenicity testing), and it presents tools for a better understanding of the toxic process (e.g., molecular modeling to explain chemical toxicity)....it presents a handsome and conveniently arranged overview of the topics and perspectives regarding the state-of-the-art of alternative toxicity testing."-EUROTOX European Societies of Toxicology

Editors and Affiliations

  • Chemical Command, Aberdeen Proving Ground, US Army Soldier and Biological, USA

    Harry Salem

  • Rutgers University, Camden, USA

    Sidney A. Katz

Bibliographic Information

  • Book Title: Toxicity Assessment Alternatives

  • Book Subtitle: Methods, Issues, Opportunities

  • Editors: Harry Salem, Sidney A. Katz

  • DOI: https://doi.org/10.1007/978-1-59259-718-5

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1999

  • Hardcover ISBN: 978-0-89603-787-8Published: 02 July 1999

  • Softcover ISBN: 978-1-4757-6863-3Published: 26 March 2013

  • eBook ISBN: 978-1-59259-718-5Published: 02 July 1999

  • Edition Number: 1

  • Number of Pages: XIII, 262

  • Number of Illustrations: 24 b/w illustrations

  • Topics: Pharmacology/Toxicology

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