Overview
- Editors:
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Beverly A. Teicher
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Dana-Farber Cancer Institute, Boston, USA
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Table of contents (19 chapters)
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Cytotoxic Agents: Old and New
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- Gerald J. Goldenberg, Malcolm J. Moore
Pages 3-22
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- Trevor W. Sweatman, Mervyn Israel
Pages 113-136
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- Marie-Christine Bissery, François Lavelle
Pages 175-193
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- Franco Zunino, Giovanni Capranico
Pages 195-214
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- Cynthia A. Romerdahl, Miguel F. Braña
Pages 215-226
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Newer Strategies and Targets
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Front Matter
Pages 227-227
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- William G. Stetler-Stevenson
Pages 241-261
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- Jill A. Hendrzak, Michael J. Brunda
Pages 263-282
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- Edward A. Sausville, Dan L. Longo
Pages 337-370
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- Walter A. Blättler, Ravi V. J. Chari, John M. Lambert
Pages 371-394
About this book
Cancer drug discovery has been and continues to be a process of ingenuity, serendip ity, and dogged determination. In an effort to develop and discover better therapies against cancer, investigators all over the world have increased our knowledge of cell biology, biochemistry, and molecular biology. The goal has been to define therapeuti cally exploitable differences between normal and malignant cells. The result has been an increased understanding of cellular and whole-organism biology and an increased respect for the flexibility and resiliency ofbiologically systems. Thus, as some new therapeutic targets have been defined and new therapeutic strategies have been attempted, so have some new biological hurdles resulting from tumor evasion of the intended therapeutic attack been discovered. Historically, anticancer drugs have originated from all available chemical sources. Synthetic molecules from the chemical industry, especially dyestuffs and warfare agents, and natural products from plants, microbes, and fungi have all been potential sources of pharmaceuticals, including anticancer agents. There is no shortage of molecules; the challenge has been and continues to be methods of identifying molecules that have the potential to be therapeutically important in human malignant disease. "Screening" remains the most important and most controversial method in cancer drug discovery. In vitro screens have generally focused on cytotoxicity and have identified several highly cytotoxic molecules. Other endpoints available in vitro are inhibition of proliferation, 3 inhibition of [ H]thymidine incorporation into DNA and various viability assays, based most frequently on dye exclusion or metabolism.
Reviews
"...extremely readable...excellent treatment of drugs such as naphthalimides...Each chapter is succinct and well-written." -Cancer Forum
"...a most important source of literature for all those who are involved in basic cancer research and in the clinical care of cancer patients in different fields of medicine." -Haematologia
Editors and Affiliations
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Dana-Farber Cancer Institute, Boston, USA
Beverly A. Teicher
