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Insulin Resistance

The Metabolic Syndrome X

  • Book
  • © 1999

Overview

Editors:
  1. Gerald M. Reaven

    1. Shaman Pharmaceuticals, Inc., South San Francisco, USA
      Stanford University School of Medicine, Stanford, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Ami Laws

    1. Stanford University School of Medicine, Stanford, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Contemporary Endocrinology (COE, volume 12)

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-x
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  2. Genetic and Environmental Factors Affecting Insulin Action

    1. Front Matter

      Pages 1-1
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    2. Genetics of Insulin Resistance

      • Michael P. Stern, Braxton D. Mitchell
      Pages 3-18

    3. Ethnic Variation in Insulin Resistance and Risk of Type 2 Diabetes

      • Paul M. McKeigue
      Pages 19-33

    4. Fetal Effects on Insulin Resistance and Glucose Tolerance

      • Paul M. McKeigue
      Pages 35-49

    5. Obesity and Insulin Resistance

      • Jean-Pierre Després, André Marette
      Pages 51-81

    6. The Role of Body Fat Distribution in Insulin Resistance

      • Abhimanyu Garg
      Pages 83-96

    7. Physical Activity and Insulin Resistance in Man

      • Flemming Dela, Kári Mikines, Henrik Galbo
      Pages 97-120

    8. Insulin Resistance in Smokers and Other Long-Term Users of Nicotine

      • Björn Eliasson, Ulf Smith
      Pages 121-136

  3. Pathophysiology of Insulin Resistance

    1. Front Matter

      Pages 137-137
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    2. Insulin Resistance and Inhibitors of Insulin Receptor Tyrosine Kinase

      • Jack F. Youngren, Ira D. Goldfine, Vincenzo Trischitta, Betty A. Maddux
      Pages 139-158

    3. NMR Studies on the Mechanism of Insulin Resistance

      • Gianluca Perseghin, Kitt Falk Petersen, Gerald I. Shulman
      Pages 159-177

    4. Skeletal Muscle Insulin Resistance in Humans: Cellular Mechanisms

      • Lawrence J. Mandarino
      Pages 179-195

    5. The Role of the Liver in Insulin Action and Resistance

      • Jerry Radziuk, Susan Pye
      Pages 197-231

    6. The Pathophysiological Consequences of Adipose Tissue Insulin Resistance

      • Gerald M. Reaven
      Pages 233-246

    7. Insulin Action and Endothelial Function

      • Alain D. Baron, Michael J. Quon
      Pages 247-263

  4. Clinical Syndromes Associated with Insulin Resistance

    1. Front Matter

      Pages 265-265
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    2. Insulin Resistance and Dyslipidemia: Implications for Coronary Heart Disease Risk

      • Ami Laws
      Pages 267-280

    3. Insulin Resistance and Blood Pressure

      • Ele Ferrannini
      Pages 281-308

    4. Microalbuminuria and Insulin Resistance

      • Jeannie Yip, Roberto Trevisan
      Pages 309-316
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Keywords

About this book

Gerald Reaven, the discoverer of Syndrome X, and a panel of world-class investigators thoughtfully summarize our current understanding of how insulin resistance and its compensating hyperinsulinemia play a major role in the pathogenesis and clinical course of high blood pressure and cardiovascular disease-the so-called diseases of Western civilization. These distinguished authorities detail, for the first time, the pathophysiological consequences and the clinical syndromes, excluding Type 2 diabetes, related to insulin resistance. They also examine the genetic and lifestyle factors that contribute to the wide differences in insulin action that exist in the population at large. Timely and authoritative, Insulin Resistance: The Metabolic Syndrome X illuminates the full importance of insulin resistance as a major cause of hypertension, heart disease, and polycystic ovary syndrome.

Reviews

"Gerald Reaven was among the pioneers in this burgeoning field. He identified insulin resistance as a risk factor for and pathophysiologic trigger of disorders as apparently unconnected as hypertension, hyperlipidemia, and polycystic ovary disease. Reaven and Laws have now brought together the diverse elements of this field in a book that will be of broad interest to the medical community. . .This book is an excellent and useful compendium of information about this rapidly moving field. It will be an essential addition to the libraries of those interested in any of the disorders linked to this prevalent metabolic state."-New England Journal of Medicine

"the authors present a critical analysis and overview of the latest research in this fast changing field. . .an authoritative work on the current state of the knowledge on insulin resistance, and its major role in the pathogenesis and development of accelerated atherosclerosis and premature cardiovascular disease-the bane of modern civilization. It is of value to all basic and clinical researchers in this field."-Quarterly Review of Biology

" This is an excellent book that will be particularly informative for those readers who are interested in understanding the mechanisms underlying the development of insulin resistance and the clinical and public health consequences of the metabolic syndrome. It should find a place on the bookshelves not only of scientists actively involved in this area of research but also of practicing physicians and medical students." ---Nutrition, Metabolism and Cardiovascular Diseases

" Each section stands out as an in-depth review of the literature on each topic. Subject matter overlaps little among the chapters, and each chapter can be read independently." ---Annals of Internal Medicine

"Who better to edit and contribute to a book on insulin resistance than Gerald Reaven, ...As a major contributor to the notion of a 'metabolic syndrome', Reaven hashelped develop our ideas in this area for many years, bringing a pattern of thinking to an extremely complex area....the breadth of the book and the universally clear presentation and focus suggest that there should be something for everyone. Laws contributes an excellent chapter on insulin resistance, dyslipidemia and CVD,...remarkably consistent across the chapters, they were well focused, logically presented and comprehensive....The insulin resistance framework forms a pattern that has proven remarkably important in helping develop research strategies and this book helped me understand the many and varied facets of this pattern." -Elsevier Science

Editors and Affiliations

  • Shaman Pharmaceuticals, Inc., South San Francisco, USA

    Gerald M. Reaven

  • Stanford University School of Medicine, Stanford, USA

    Gerald M. Reaven, Ami Laws

Bibliographic Information

  • Book Title: Insulin Resistance

  • Book Subtitle: The Metabolic Syndrome X

  • Editors: Gerald M. Reaven, Ami Laws

  • Series Title: Contemporary Endocrinology

  • DOI: https://doi.org/10.1007/978-1-59259-716-1

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1999

  • Hardcover ISBN: 978-0-89603-588-1Published: 01 April 1999

  • Softcover ISBN: 978-1-61737-086-1Published: 09 November 2010

  • eBook ISBN: 978-1-59259-716-1Published: 01 April 1999

  • Series ISSN: 2523-3785

  • Series E-ISSN: 2523-3793

  • Edition Number: 1

  • Number of Pages: X, 374

  • Topics: Endocrinology

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