Molecular and Cellular Pediatric Endocrinology

1. Front Matter

   Pages i-x

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2. Molecular Basis of Disorders of Sexual Differentiation

   • Gary D. Berkovitz, Tossaporn Seeherunvong

   Pages 1-9

3. Insulin-Like Growth Factor Control of Growth

   • Steven D. Chernausek

   Pages 11-21

4. Molecular Defects in the Growth Hormone Axis

   • Joy D. Cogan, John A. Phillips III

   Pages 23-38

5. The Molecular Basis of Hypophosphatemic Rickets

   • Michael J. Econs, Tim M. Strom

   Pages 39-55

6. The Roles of Growth Hormone, Prolactin, and Placental Lactogen in Human Fetal Development

   • Michael Freemark

   Pages 57-83

7. Growth Hormone Releasing Hormone

   • Paul L. Hofman, O. H. Pescovitz

   Pages 85-112

8. The Glomerular Physiology of Diabetic Nephropathy

   • David J. Klein

   Pages 113-137

9. P450c17—The Qualitative Regulator of Steroidogenesis

   • Walter L. Miller

   Pages 139-152

10. The Molecular Basis of Inherited Diabetes Insipidus

    • David R. Repaske

    Pages 153-177

11. Molecular Biology of Gonadotropin-Releasing Hormone and the Gonadotropin-Releasing Hormone Receptor

    • Dorothy I. Shulman, Barry B. Bercu

    Pages 179-189

12. Estrogen Biology

    • Eric P. Smith

    Pages 191-200

13. Molecular Genetics of Thyroid Cancer

    • Laura S. Ward, James A. Fagin

    Pages 201-211

14. The Molecular Basis of Mineralocorticoid Action

    • Perrin C. White

    Pages 213-230

15. Molecular Aspects of Pituitary Development

    • Philip S. Zeitler, Cheryl A. Pickett

    Pages 231-251

16. Physiology and Molecular Biology of Placental Lactogen in Human Pregnancy

    • Randall G. Richards, Stuart Handwerger

    Pages 253-270

17. Molecular and Cellular Basis of Immune-Mediated (Type 1) Diabetes

    • Regis Coutant, Noel K. MacLaren

    Pages 271-296

18. Molecular Basis of Multiple Pituitary Hormone Deficiency

    • John S. Parks, Milton R. Brown

    Pages 297-307

19. Back Matter

    Pages 309-317

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Stuart Handwerger, MD and a distinguished panel of clinicians and experts review the most significant recent developments in molecular and cellular biology, powerful advances that have produced new diagnostic methods and improved treatments for many pediatric endocrine diseases. Topics range from the growth hormone/prolactin/placental lactogen gene family and their regulation of growth, to steroid hormones, sexual development, and mineral corticoid action. Additional chapters examine the pathophysiology of insulin-dependent diabetes mellitus, the molecular genetics of thyroid cancer, the molecular basis of hypophosphatemic rickets, and inherited diabetes insipidus. Molecular and Cellular Pediatric Endocrinology offers today's clinicians and researchers not only the latest findings on endocrine diseases in their pediatric manifestations, but also highly practical insights into today's cutting-edge diagnostics, treatment strategies, and powerful new therapeutics.

• Diabetes
• Diabetes mellitus
• Gonadotropin
• growth factor
• insulin-like
• prolactin

". . . overview[s] the most rapidly developing areas of advances in molecular advances and their applications to the study, diagnosis, and treatment of pediatric endocrine disorders. The first seven chapters focus on the regulation of growth and the growth hormone/prolactin/placental lactogen gene family. Steroid hormones, sexual development, and mineralacortoid action are discussed in the next five chapters (including a review of the first human case of estrogen receptor defects). The pathophysiology of diabetes mellitus is the subject of two chapters. The rest of the text treats the molecular genetics of thyroid cancer, hypophosphatemic rickets, and inherited diabetes insipidus."-SciTech Book News

". . .cuts a wide and deep swath through the basic biology and pathology of the disorders [pediatric endocrinologists] deal with in the clinic every day. No matter your disease(s) of interest, its molecular/cellular basis is covered in this mutiauthored book. . . well referenced."-PedEndoGram

"A useful addition to clinical pediatric endocrinology and of interest also to geneticists."-Journal of Pediatric Endocrinology and Metabolism

• Division of Endocrinology, Children’s Hospital Medical Center, Cincinnati, USA

  Stuart Handwerger

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