Intraoperative Irradiation

1. Front Matter

   Pages i-xvii

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2. General Rationale and Historical Perspective

   1. Front Matter

      Pages N1-N1

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   2. General Rationale and Historical Perspective of Intraoperative Irradiation

      • Leonard L. Gunderson, Felipe A. Calvo, Christopher G. Willett, Louis B. Harrison, Manuel Santos

      Pages 1-24

   3. Biology of Large Dose per Fraction Radiation Therapy

      • Paul Okunieff, Srinath Sundararaman, Yuhchyaw Chen

      Pages 25-46

3. Methods and Techniques of Treatment

   1. Front Matter

      Pages N3-N3

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   2. Physical Aspects of Intraoperative Electron-Beam Irradiation

      • Edwin C. McCullough, Peter J. Biggs

      Pages 47-63

   3. IOERT Treatment Factors

      • Christopher G. Willett, Leonard L. Gunderson, Paul M. Busse, David Nagorney, Joel E. Tepper, Felipe A. Calvo

      Pages 65-85

   4. Physics of Intraoperative High-Dose-Rate Brachytherapy

      • Lowell L. Anderson, Patrick J. Harrington, Jean St. Germain

      Pages 87-104

   5. High-Dose-Rate Intraoperative Irradiation (HDR-IORT)

      • Louis B. Harrison, Alfred M Cohen, Warren E. Enker

      Pages 105-110

   6. Intraoperative Irradiation with Electron-Beam or High-Dose-Rate Brachytherapy

      • Subir Nag, Leonard L. Gunderson, Christopher G. Willett, Louis B. Harrison, Felipe A. Calvo

      Pages 111-130

4. Normal Tissue Tolerance—IORT

   1. Front Matter

      Pages N5-N5

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   2. Normal Tissue Tolerance to Intraoperative Irradiation

      • William F. Sindelar, Peter A. S. Johnstone, Harald J. Hoekstra, Timothy J. Kinsella

      Pages 131-145

   3. Studies at Colorado State University of Normal Tissue Tolerance of Beagles to IOERT, EBRT, or a Combination

      • Edward L. Gillette, Sharon M Gillette, Barbara E. Powers

      Pages 147-163

   4. Peripheral Nerve Tolerance

      • Edward Gillette, Barbara E. Powers, Sharon M. Gillette, Leonard L. Gunderson, Christopher G. Willett

      Pages 165-173

5. Results of IORT With or Without EBRT by Disease Site

   1. Front Matter

      Pages N7-N7

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   2. Gastric IORT With or Without EBRT

      • Rafael Martinez-Monge, Jean P. Gerard, H. J. Kramling, F. Guillemin, Felipe A. Calvo

      Pages 175-200

   3. IORT in Pancreatic Carcinoma

      • Paula M. Termuhlen, Douglas B. Evans, Christopher G. Willett

      Pages 201-222

   4. Biliary Tract IORT

      • Takeshi Todoroki, Leonard L. Gunderson, David Nagorney

      Pages 223-247

   5. Primary Colorectal EBRT and IOERT

      • Christopher G. Willett, Paul C. Shellito, Leonard L. Gunderson

      Pages 249-272

   6. Recurrent Colorectal

      • Leonard L. Gunderson, Christopher G. Willett, Michael G. Haddock, Heidi Nelson, Ignacio Azinovic, Subir Nag et al.

      Pages 273-305

International radiation oncologists, surgeons, and scientists comprehensively review the techniques, indications, and results of using intraoperative electrons (IOERT) and high-dose rate brachytherapy (HDR-IORT). State-of-the-art topics range from methods and techniques of treatment and issues of normal tissue/organ tolerance to IORT, to techniques and results by disease-site, as well as future possibilities. The disease-site chapters cover every body part for which the potential merit of IORT has been demonstrated, with disease-specific treatment factors presented by a radiation oncologist and a surgeon. The diseases range from GI cancers to CNS and breast malignancies. International in authorship and comprehensive in scope, Intraoperative Irradiation: Techniques and Results offers a cutting-edge resource and reference for surgeons, radiation oncologists, physicists, anesthesiologists, medical oncologists, and all others involved in providing IORT and HDR-IORT procedures and cancer care today.

• Gunderson
• Harrison
• IOERT
• Intraoperative Radiation Therapy
• Tumor
• bone
• brachytherapy
• breast cancer
• carcinoma
• liver
• metastasis
• pancreas
• radiation
• radiation oncology
• radiotherapy

". . . chapters are very well written in a concise manner and include excellent bibliographies. . .a thorough, well written, informative textbook which would be a welcome addition to the radiation and surgical oncologist's reference library. "-Doody's Health Sciences Book Review Journal

"This comprehensive review by internationally recognized radiation oncologists, surgeons and scientists likely represents the definitive text on intraoperative irradiation and allied techniques...a useful reference for the dedicated multidisciplinary oncology team, wishing to have a comprehensive review of these techniques (and current results)...The biophysics of a single high dose versus multiple small doses is well covered in this text."-Canadian Journal of Surgery

"...an appropriate resource and reference book. It is intended for surgeons, radiation oncologists, physicists, anesthetists, medical oncologists, and all others involved either in the procedural component of IORT or in the care of patients with cancer."-Neoplasma

"The panel of investigators asked to be offer their contribution is impressive. All investigators dealing with IORT in their institution should have this book in their library, since they are given the opportunity to know (almost) everything on this technique."-Annals of Oncology

• Mayo Clinic and Mayo Medical School, Rochester, USA

  Leonard L. Gunderson

• Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, USA

  Christopher G. Willet

• Albert Einstein College of Medicine and Beth Israel Cancer Center, New York, USA

  Louis B. Harrison

• University Hospital Gregorio Marañón, Madrid, Spain

  Felipe A. Calvo

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