Overview
- Editors:
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Arne Schousboe
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Department of Pharmacology, The Danish University of Pharmaceutical Sciences, Copenhagen, Denmark
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Hans Bräuner-Osborne
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Department of Medical Chemistry, The Danish University of Pharmaceutical Sciences, Copenhagen, Denmark
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Table of contents (13 chapters)
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Molecular Pharmacology of Glutamate Receptors
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- Jeremy R. Greenwood, Tommy Liljefors
Pages 3-25
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- Sari E. Lauri, Vernon R. J. Clarke, Graham L. Collingridge
Pages 27-46
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Molecular Pharmacology of GABA Receptors
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- Bjarke Ebert, Sally Anne Thompson, Signe Í. Stórustovu, Keith A. Wafford
Pages 85-94
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- Bente Frølund, Anne T. Jørgensen, Tommy Liljefors, Martin Mortensen, Povl Krogsgaard-Larsen
Pages 113-127
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- Bernhard Bettler, Hans Bräuner-Osborne
Pages 129-144
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Molecular Pharmacology of Transmitter Transporters
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Front Matter
Pages 145-145
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- Baruch I. Kanner, Michael P. Kavanaugh, Lars Borre
Pages 147-159
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- Robert J. Vandenberg, Renae M. Ryan
Pages 161-174
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- Alan Sarup, Orla Miller Larsson, Arne Schousboe
Pages 175-190
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- Claus Juul Loland, Ulrik Gether
Pages 191-212
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- Naomi R. Goldberg, Thijs Beuming, Harel Weinstein, Jonathan A. Javitch
Pages 213-234
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- Marta Filizola, Irache Visiers, Lucy Skrabanek, Fabien Campagne, Harel Weinstein
Pages 235-266
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Back Matter
Pages 267-271
About this book
A powerful collection of readily reproducible cutting-edge techniques for characterizing the ligand or substrate binding of neurotransmitter receptors and transporters. The procedures cover interdisciplinary interactions for monoamine transporters, amino acid transporters, ionotropic receptors, metabotropic glutamate receptors, GABA receptors, and other G protein-coupled receptors. By illuminating how neurons in the central nervous communicate with other, these techniques can lead to the development of novel therapeutic strategies for neurological diseases.
Reviews
"I would highly recommend this book to neuroscientists, pharmacologists, and medicinal chemists who are interested in ligand-macromolecular interactions. It provides descriptions of state-of-the-art tools needed to understand how CNS neurons communicate and perspectives regarding the development of novel therapeutic drugs for neurological diseases. Each chapter is well written and concise beginning with an appropriate introduction to the topic and ending with a brief summary, conclusion, or future perspective section. The references are selective and appropriate. Special features include cutting-edge techniques for using site directed mutagenesis and molecular modeling; novel insights into the functioning of transmitter receptors and transporters; and state-of-the-art discussions on the molecular pharmacology of GABA and glutamate receptors and transmitter transporters. "-Doody's Health Sciences Book Review Journal
"...provides a highly readable account...an excellent book." - ChemBioChem
Editors and Affiliations
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Department of Pharmacology, The Danish University of Pharmaceutical Sciences, Copenhagen, Denmark
Arne Schousboe
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Department of Medical Chemistry, The Danish University of Pharmaceutical Sciences, Copenhagen, Denmark
Hans Bräuner-Osborne
