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  • Book
  • © 2004

Hepatitis B and D Protocols

Volume 2: Immunology, Model Systems, and Clinical Studies

Editors:

  1. Robert K. Hamatake

    1. Ribapharm Inc., Costa Mesa

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Johnson Y. N. Lau

    1. Ribapharm Inc., Costa Mesa

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Methods in Molecular Medicine (MIMM, volume 96)

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Table of contents (36 protocols)

  1. Front Matter

    Pages i-xxiii
    PDF

  2. Viral-Specific Immunological and Other Host Responses

    1. Front Matter

      Pages 1-1
      PDF

    2. Studying Host Immune Responses Against Duck Hepatitis B Virus Infection

      • Darren S. Miller, Edward M. Bertram, Catherine A. Scougall, Ieva Kotlarski, Allison R. Jilbert
      Pages 3-25

    3. Measurement of Cell-Mediated Immune Response in Woodchucks

      • Stephan Menne, Paul J. Cote
      Pages 27-36

    5. Induction of Anti-Hepatitis B Virus Immune Responses Through DNA Immunization

      • Michael Geissler, Robert Weth, Christian F. Grimm, Dörte Ortmann, Hubert E. Blum
      Pages 43-54

    7. Determination of Hepatitis B Virus-Specific CD8+ T-Cell Activity in the Liver

      • Michelina Nascimbeni, Barbara Rehermann
      Pages 65-83

    10. In Vitro Analysis of Hepatitis B Virus Specific CD4+ T Cells

      • Shilpa Chokshi, Nikolai V. Naoumov
      Pages 97-109

    11. Induction of Humoral and Cellular Immune Responses to Hepatitis Delta Virus Through DNA Immunization in BALB/c Mice

      • Ren-Shiang Lee, Shih-Jer Hsu, Li-Rung Huang, Hui-Lin Wu, Shiou-Lin Lin, Ding-Shinn Chen et al.
      Pages 111-128

  3. In Vitro and In Vivo Models

    1. Front Matter

      Pages 129-129
      PDF

    4. The Tupaia Model for the Study of Hepatitis B Virus

      • Fritz von Weizsäcker, Josef Köck, Sabine MacNelly, Shaotang Ren, Hubert E. Blum, Michael Nassal
      Pages 153-161

    6. Woodchuck Hepatitis Virus Hepatocyte Culture Models

      • Norma D. Churchill, Tomasz I. Michalak
      Pages 175-187

    7. Duck Hepatitis B Virus Primary Hepatocyte Culture Model

      • Olivier Hantz, Fabien Zoulim
      Pages 189-197
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About this book

Despite the availability of an effective vaccine, there are still 400 million people, worldwide who are chronically infected with hepatitis B virus (HBV). For them, the vaccine, as currently applied, has no value. Given the possible consequences of HBV infection, the number of those chronically infected with HBV presents an enormous public health challenge. For example, the major etiology of hepatocellular carcinoma (HCC) is chronic infection with HBV. Although fifth in cancer incidence, worldwide, HCC/liver cancer is the third leading cause of cancer death. The high mortality as- ciated with HCC arises because the disease is often detected late and is unresponsive to treatment. The number of deaths caused by PHCC is expected to rise over the next 20 years. Those chronically infected with HBV have a life risk of death to HCC of between 10 and 25%. Even the limited efficacy of drugs for the treatment of chronic HBV helps underscore the point that this disease is responsive to therapy. Drugs that target the polymerase (e. g. , hepsera and lamivudine) and interferon alpha represent two distinct strategies and show that both conventional antiviral and immunothe- peutic approaches can be used in management. However, the current inventory of therapeutics is inadequate. Interferon alpha is of limited value, only parenterally ava- able, and fraught with adverse reactions.
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Keywords

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Reviews

"Both volumes provide an excellent reference for background information and detailed experimental investigations for both Hepatitis B and Hepatitis D. A major attribute of the volumes is that as they cover a wide range of subjects, the reader has the opportunity to access information they would not normally encounter. Volumes 1 and 2 are an excellent reference source and the methodologies described present the opportunity for both new and experienced researchers to study the molecular aspects of HBV and HDV infection."-SGM Quarterly

"...an excellent reference for background information and detailed experimental investigations for both Hepatitis B and Hepatitis D..." - Microbiology Today
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Editors and Affiliations

  • Ribapharm Inc., Costa Mesa

    Robert K. Hamatake, Johnson Y. N. Lau

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Bibliographic Information

  • Book Title: Hepatitis B and D Protocols

  • Book Subtitle: Volume 2: Immunology, Model Systems, and Clinical Studies

  • Editors: Robert K. Hamatake, Johnson Y. N. Lau

  • Series Title: Methods in Molecular Medicine

  • DOI: https://doi.org/10.1385/1592596703

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Protocols

  • Copyright Information: Humana Press 2004

  • Hardcover ISBN: 978-1-58829-108-0Published: 28 January 2004

  • Softcover ISBN: 978-1-61737-363-3Published: 09 November 2010

  • eBook ISBN: 978-1-59259-670-6Published: 02 February 2008

  • Series ISSN: 1543-1894

  • Series E-ISSN: 1940-6037

  • Edition Number: 1

  • Number of Pages: XXIII, 572

  • Topics: Infectious Diseases

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Buy it now

eBook USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

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