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Table of contents (20 chapters)
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Front Matter
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Molecular Markers
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Front Matter
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Diseased Regulatory Pathways
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Front Matter
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Future Directions
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Front Matter
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Keywords
About this book
At the midpoint of the 20th century, our knowledge of cancer was based on epide- ology and pathology, and treatment consisted of surgery and radiation therapy. At mid-century, Medawar and colleagues initiated the understanding of transplantation immunology, Farber described the first use of an antifolic drug to treat leukemia, and Jacobson and coworkers described the irradiation-protection effect of spleen cells. These observations opened the door to the development of chemotherapy and tra- plantation in the treatment of cancer. Despite the rapid development of these new disciplines, progress was usually based on empiric observations and clinical trials. The rapid advances in molecular biology at the end of the 20th century mark a new era in our knowledge of cancer. Molecular immunology, molecular genetics, mole- lar pharmacology, and the Human Genome Project are in the process of providing a level of understanding of cancer undreamed of in the past. Optimism is based on the firm belief that understanding at the molecular level will lead to better and earlier di- nosis, to new forms of treatment, and, most importantly, eventually to prevention of many types of cancer.
Reviews
"this is an excellent book that brings together leading experts in the field who have done a superb job of succinctly describing the advances in the basic sciences over the last few years and in showing how these advances have translated into improvements in cancer care. This book will be useful to anyone who studies cancer biology or takes care of cancer patients. "-Doody's Health Sciences Book Review Journal
"...comprehensive and intellectually stimulating...not only clearly elucidates the fundamentals of this dramatically advancing field, but also interprets the vast and often complex molecular data available." - Tumori
From the foreword:
"Principles of Molecular Oncology provides valuable information for the continuing education of all oncologists."-Derek Crowther, PhD, MB BChir, FRCP, FRCR, University of Manchester and Christie Cancer Center, Manchester, UK
Reviews of the First Edition:
"All the aspects of this complex and rapidly moving field are covered in this excellent book. Clinical oncologists will find a series of balanced reviews of the current state-of-the-art of the diagnosis and treatment of cancer based on molecular technology, and since cancer touches almost every field of clinical practice, specialists in other disciplines will find a very lucid and readable account of what is happening in one of the genuine success stories of molecular medicine."
From the foreword by Sir David Weatherall, FRS, Institute of Molecular Medicine, Oxford University, UK
"Principles of Molecular Oncology provides a bold new look at the evolution of our knowledge of cancer. Authors from many disciplines are bringing together the facets that provide a comprehensive view of the whole...The reader will enjoy the opportunity to pause and look at the whole field as it stands today. The book will be both informative and intellectually stimulating."
From the foreword by E. Donnall Thomas, MD, Fred Hutchinson Cancer Research Center and Nobel Laureate in Medicine/Physiology, 1990
"This book is a broad yet comprehensive synopsis of the emerging field of molecular oncology. . .A detailed framework of the molecular basis of cancer and the potential utility in both diagnosis and treatment is presented. One area covered particularly well is apoptosis, with an emphasis on the clinical relevance of modulating this pathway in human neoplasia. In summary, this text is a nice presentation of the varied pathways that are disrupted in a cancer cell and suggestions of potential clinically useful targets for therapeutic intervention. . .This is a welcome addition to a clinician's library, facilely read from cover to cover."-Doody's Health Sciences Book Review Journal
"Practicing physicians and advanced medical students as well as biochemists molecular biologists, and geneticists involved in the identification of molecular markers, therapeutic targets , and the underlying basis of cancer will all benefit from the addition of Principles of Molecular Oncology to their bookshelves."-The Lancet
"...comprehensive and intellectually stimulating...not only clearly elucidates the fundamentals of this dramatically advancing field, but also interprets the vast and often complex molecular data available." - Tumori
From the foreword:
"Principles of Molecular Oncology provides valuable information for the continuing education of all oncologists."-Derek Crowther, PhD, MB BChir, FRCP, FRCR, University of Manchester and Christie Cancer Center, Manchester, UK
Reviews of the First Edition:
"All the aspects of this complex and rapidly moving field are covered in this excellent book. Clinical oncologists will find a series of balanced reviews of the current state-of-the-art of the diagnosis and treatment of cancer based on molecular technology, and since cancer touches almost every field of clinical practice, specialists in other disciplines will find a very lucid and readable account of what is happening in one of the genuine success stories of molecular medicine."
From the foreword by Sir David Weatherall, FRS, Institute of Molecular Medicine, Oxford University, UK
"Principles of Molecular Oncology provides a bold new look at the evolution of our knowledge of cancer. Authors from many disciplines are bringing together the facets that provide a comprehensive view of the whole...The reader will enjoy the opportunity to pause and look at the whole field as it stands today. The book will be both informative and intellectually stimulating."
From the foreword by E. Donnall Thomas, MD, Fred Hutchinson Cancer Research Center and Nobel Laureate in Medicine/Physiology, 1990
"This book is a broad yet comprehensive synopsis of the emerging field of molecular oncology. . .A detailed framework of the molecular basis of cancer and the potential utility in both diagnosis and treatment is presented. One area covered particularly well is apoptosis, with an emphasis on the clinical relevance of modulating this pathway in human neoplasia. In summary, this text is a nice presentation of the varied pathways that are disrupted in a cancer cell and suggestions of potential clinically useful targets for therapeutic intervention. . .This is a welcome addition to a clinician's library, facilely read from cover to cover."-Doody's Health Sciences Book Review Journal
"Practicing physicians and advanced medical students as well as biochemists molecular biologists, and geneticists involved in the identification of molecular markers, therapeutic targets , and the underlying basis of cancer will all benefit from the addition of Principles of Molecular Oncology to their bookshelves."-The Lancet
Editors and Affiliations
Bibliographic Information
Book Title: Principles of Molecular Oncology
Editors: Miguel H. Bronchud, MaryAnn Foote, Giuseppe Giaccone, Olufunmilayo I. Olopade, Paul Workman
DOI: https://doi.org/10.1007/978-1-59259-664-5
Publisher: Humana Totowa, NJ
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eBook Packages: Springer Book Archive
Copyright Information: Springer Science+Business Media New York 2004
eBook ISBN: 978-1-59259-664-5Published: 03 December 2003
Edition Number: 2
Number of Pages: XXI, 709
Number of Illustrations: 45 b/w illustrations
Topics: Oncology