Chiral Separations

1. Front Matter

   Pages i-xiii

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2. Chiral Separation Principles

   • Gerald Gübitz, Martin G. Schmid

   Pages 1-28

3. Separation of Enantiomers by Thin-Layer Chromatography

   • Kurt Günther, Peter Richter, Klaus Möller

   Pages 29-59

4. Cyclodextrin-Based Chiral Stationary Phases for Liquid Chromatography

   • Clifford R. Mitchell, Daniel W. Armstrong

   Pages 61-112

5. Enantiomeric Separations by HPLC Using Macrocyclic Glycopeptide-Based Chiral Stationary Phases

   • Tom Ling Xiao, Daniel W. Armstrong

   Pages 113-171

6. Chiral Separation by HPLC Using Polysaccharide-Based Chiral Stationary Phases

   • Chiyo Yamamoto, Yoshio Okamoto

   Pages 173-181

7. Applications of Polysaccharide-Based Chiral Stationary Phases for Resolution of Different Compound Classes

   • Hassan Y. Aboul-Enein, Imran Ali

   Pages 183-196

8. Chiral Separation by HPLC With Pirkle-Type Chiral Stationary Phases

   • Myung Ho Hyun, Yoon Jae Cho

   Pages 197-205

9. Chiral Separation by HPLC Using the Ligand-Exchange Principle

   • Vadim A. Davankov

   Pages 207-215

10. Chiral Separations by HPLC Using Molecularly Imprinted Polymers

    • Peter Spégel, Lars I. Andersson, Staffan Nilsson

    Pages 217-229

11. Indirect Enantioseparation by HPLC Using Chiral Benzofurazan-Bearing Reagents

    • Toshimasa Toyo’oka

    Pages 231-246

12. Separation of Racemic Trans-Stilbene Oxide by Sub-/Supercritical Fluid Chromatography

    • Leo Hsu, Genevieve Kennedy, Gerald Terfloth

    Pages 247-253

13. Chiral Separations Using the Macrocyclic Antibiotics in Capillary Electrophoresis

    • Timothy J. Ward, Colette M. Rabai

    Pages 255-263

14. Enantioresolutions by Capillary Electrophoresis Using Glycopeptide Antibiotics

    • Salvatore Fanali

    Pages 265-273

15. Separation of Enantiomers by Capillary Electrophoresis Using Cyclodextrins

    • Wioleta Maruszak, Martin G. Schmid, Gerald Gübitz, Elzbieta Ekiert, Marek Trojanowicz

    Pages 275-289

16. Chiral Separations by Capillary Electrophoresis Using Proteins as Chiral Selectors

    • Jun Haginaka

    Pages 291-305

17. Cellulases as Chiral Selectors in Capillary Electrophoresis

    • Gunnar Johansson, Roland Isaksson, Göran Pettersson

    Pages 307-315

18. Use of Chiral Crown Ethers in Capillary Electrophoresis

    • Martin G. Schmid, Gerald Gübitz

    Pages 317-321

19. Chiral Separations by Capillary Electrophoresis Using Cinchona Alkaloid Derivatives as Chiral Counter-Ions

    • Michael Lämmerhofer, Wolfgang Lindner

    Pages 323-342

20. Chiral Separation by Capillary Electrophoresis Using Polysaccharides

    • Hiroyuki Nishi

    Pages 343-353

Methods for enantiomer separation are very important for controlling synthesis, for checking racemization, for enantiomeric purity control, and for pharmacokinetic studies. In Chiral Separations: Methods and Protocols, prominent experts from around the world detail the chromatographic and electroseparation techniques they have developed for chiral separations on an analytical scale. Described in step-by-step detail to ensure successful experimental results, the procedures are presented as either general methods or as specific applications to substance classes and special compounds, with emphasis on high performance liquid chromatography and capillary electrophoresis techniques, but also including thin layer chromotogrphic, gas chromatographic, and supercritical fluid chromatographic as well as recent electrochromotographic techniques. Each fully tested protocol includes an introduction to the principle underlying the method, equipment and reagent lists, and helpful notes on troubleshooting and avoiding known pitfalls.
Up-to-date and highly practical, Chiral Separations: Methods and Protocols will help both novice and advanced users not only choose optimal methods for their separation problems, but also readily obtain successful results.

"It is an excellent book, and can be recommended for every laboratory involved in the synthesis and analysis of chiral compounds. Moreover, the editors have succeeded in getting internationally known leading experts to write the contributions." -Angewandte Chemie

"...will undoubtedly be of value to those who need to find useful ways to carry out such separations." -Journal of Medicinal Chemistry

"...this book is a useful compendium of chiral methods and will be of use to many workers in the field." - Biomed Chronatogr

• Institute of Pharmaceutical Chemistry and Pharmaceutical Technology, Karl-Franzens University, Graz, Austria

  Gerald Gübitz, Martin G. Schmid

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