Animal Models of Neurological Disease, I

1. Front Matter

   Pages i-xvi

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2. Ethics of Animal Models of Neurological Diseases

   • Ernest D. Olfert

   Pages 1-28

3. Animal Models of Alzheimer’s Disease

   • Gary L Wenk

   Pages 29-63

4. Animal Models of Huntington’s Disease

   • Dwaine F. Emerich, Paul R. Sanberg

   Pages 65-134

5. Rodent Models of Parkinson’s Disease

   • FranÇois B. Jolicoeur, Robert Rivest

   Pages 135-158

6. Primate Models of Parkinson’s Disease

   • Paul J. Bédard, René Boucher, Baltazar Gomez-Mancilla, Pierre Blanchette

   Pages 159-173

7. Genetic Dysmyelination Models

   • Gregory Konat, Richard C. Wiggins

   Pages 175-203

8. Nongenetic Animal Models of Myelin Disorders

   • Sheldon L. Miller

   Pages 205-273

9. Animal Models of the Cerebellar Ataxias

   • Roger F. Butterworth

   Pages 275-294

10. Animal Models for Lesch-Nyhan Disease

    • Roberta M. Palmour

    Pages 295-352

11. Back Matter

    Pages 353-368

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to the Animal Models Volumes This and several other volumes in the Neuromethods series will describe a number of animal models of neu- psychiatric disorders. Because of increasing public concern over the ethical treatment of animals in research, we felt it incumbent upon us to include this general preface to these volumes in order to indicate why we think further research using animals is necessary and why animal models of psychi- ric and neurologic disorders, in particular, are so important. We recognize that animals should only be used when suitable alternatives are not available. We think it self-e- dent, however, that humans can only be experimented upon in severely proscribed circumstances and alternative pro- dures using cell or tissue culture are inadequate in any models requiring assessments of behavioral change or of complex in vivo processes. However, when the distress, discomfort, or pain to the animals outweighs the anticipated gains for human welfare, then the research is not ethical and should not be carried out.

These books go out of their way to be helpful. Most chapters introduce the animal models against the background of the human (i.e., clinical) context and conclude with a brief summary. Detailed experimental protocols and useful tabulations abound. Descriptions are exhaustive.-Trends in Neurosciences

• University of Saskatchewan, Saskatoon, Canada

  Alan A. Boulton

• University of Alberta, Edmonton, Canada

  Glen B. Baker

• University of Montreal, Montreal, Canada

  Roger F. Butterworth

Policies and ethics