Overview
- Editors:
-
-
Sudhir Agrawal
-
Hybridon, Inc., Worcester
Access this book
Other ways to access
Table of contents (14 protocols)
-
Front Matter
Pages i-xiii
-
-
- C. Frank Bennett, Nicholas Dean, David J. Ecker, Brett P. Monia
Pages 13-46
-
- Leonard M. Neckers, Daniel Geselowitz, Christine Chavany, Luke Whitesell, Raymond Bergan
Pages 47-56
-
- Marina Catsicas, Astrid Osen-Sand, Julie K. Staple, Kenneth A. Jones, Guidon Ayala, Jonathan Knowles et al.
Pages 57-85
-
-
- Anil P. Amaratunga, Kenneth S. Kosik, Peter A. Rittenhouse, Susan E. Leeman, Richard E. Fine
Pages 109-119
-
- Michael Simons, Robert D. Rosenberg
Pages 121-141
-
- Wolf-Bernhard Offensperger, Silke Offensperger, Hubert E. Blum
Pages 143-158
-
- Wolfgang Brysch, Abdalla Rifai, Wolfgang Tischmeyer, Karl-Hermann Schlingensiepen
Pages 159-182
-
- Jose R. Perez, Kimberly A. Higgins-Sochaski, Jean-Yves Maltese, Ramaswamy Narayanan
Pages 183-199
-
- Patrick L. Iversen, Bryan L. Copple, Hemant K. Tewary, Eliel Bayever, Michael R. Bishop
Pages 201-212
-
- Yoon S. Cho-Chung, Maria Nesterova
Pages 213-224
-
- Bernard J. Chiasson, Murray Hong, Michele L. Hooper, John N. Armstrong, Paul R. Murphy, Harold A. Robertson
Pages 225-245
-
- Sudhir Agrawal, Jamal Temsamani
Pages 247-270
-
Back Matter
Pages 271-276
About this book
Leading researchers offer an authoritative survey and analysis of the latest findings on the rapid development of antisense oligonucleotides therapeutic and their application in various in vivo model systems. The book's high-profile contributors provide timely accounts of their state-of-the-art strategies, discussing such topics as the synthesis and purification of oligonucleotides, their selection for a particular gene target, different methods of administration, and the use of various cell lines and cell culture systems. They also examine questions of cellular uptake, in vitro biological activity, in vivo biological activity, the pharmacology and pharmacokinetics of oligonucleotides, and the application of oligonucleotides to the central nervous system.
Reviews
...a timely addition to the literature in this field... strongly recommended both to scientists already engaged in antisense research and to newcomers alike...a 'must' for all those wishing to 'stop making sense' with nucleic acid therapeutics in in vivo studies. -Trends in Biotechnology
Editors and Affiliations
-
Hybridon, Inc., Worcester
Sudhir Agrawal
