Highly Selective Neurotoxins

1. Front Matter

   Pages i-xii

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2. 6-Hydroxydopamine and Related Catecholaminergic Neurotoxins

   • C. LeRoy Blank, Russell J. Lewis, Roland E. Lehr

   Pages 1-18

3. The Use of Neurotoxins to Lesion Catecholamine-Containing Neurons to Model Clinical Disorders

   • Charles R. Breese, George R. Breese

   Pages 19-73

4. 6-Hydroxydopamine as a Tool for Studying Catecholamines in Adult Animals

   • Michael J. Zigmond, Kristen A. Keefe

   Pages 75-107

5. 6-Hydroxydopa, a Catecholamine Neurotoxin and Endogenous Excitotoxin at Non-NMDA Receptors

   • Richard M. Kostrzewa

   Pages 109-129

6. 2-Chloroethylamines (DSP4 and Xylamine)

   • Guillermo Jaim-Etcheverry

   Pages 131-140

7. MPTP

   • Joyce E. Royland, J. William Langston

   Pages 141-194

8. Haloperidol-Derived Pyridinium Metabolites

   • Cornelis J. Van der Schyf, Etsuko Usuki, Susan M. Pond, Neal Castagnoli Jr.

   Pages 195-210

9. The Neurotoxic Effects of Continuous Cocaine and Amphetamine in Habenula

   • Gaylord Ellison

   Pages 211-233

10. Evidence for and Mechanism of Action of Neurotoxicity of Amphetamine Related Compounds

    • R. Lew, J. E. Malberg, George A. Ricuarte, Lewis S. Seiden

    Pages 235-268

11. Molecular Mechanisms of Action of 5,6- and 5,7-Dihydroxytryptamine

    • Tahereh Tabatabaie, Glenn Dryhurst

    Pages 269-291

12. Use of 5,6- and 5,7-Dihydroxytryptamine to Lesion Serotonin Neurons

    • Michael R. Pranzatelli

    Pages 293-311

13. Selective Cholinergic Neurotoxins

    • Thomas J. Walsh, Pamela E. Potter

    Pages 313-327

14. Glutamatergic Receptor Agonists and Brain Pathology

    • Ewa M. Urbanska, Andrzej Dekundy, Zdzislaw Kleinrok, Waldemar A. Turski, Stanislaw J. Czuczwar

    Pages 329-354

15. Neurotoxiciy of NMDA Receptor Antagonists

    • Sunita Rajdev, Frank R. Sharp

    Pages 355-384

16. Toxic Vanilloids

    • Arpad Szallasi

    Pages 385-398

17. Back Matter

    Pages 399-404

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Expert researchers critically review and evaluate the most common and important neurotoxins used today in neuroscience research. Each informative chapter thoroughly describes the significant mechanisms of action of a neurotoxin, as well as fully discussing the limits on their use and their clinical applicability. Several clinically oriented chapters are significant for neurologists treating Parkinsonism, for psychiatrists treating drug abuse and neurodegenerative disorders, and for primary care physicians treating patients with appetite suppressants. Highly Selective Neurotoxins provides all the basic knowledge needed to obtain a predictable experimental outcome with these neurotoxins.

• Neuroscience
• Parkinson
• amphetamine
• catecholamines
• cocaine
• dopamine
• neural mechanisms
• neurons
• neurotoxicity

• Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, Johnson City, USA

  Richard M. Kostrzewa

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