Cell Transplantation for Neurological Disorders

1. Front Matter

   Pages i-xviii

   PDF

2. The Lund Transplant Program for Parkinson’s Disease and Patients with MPTP-Induced Parkinsonism

   • Håkan Widner

   Pages 1-17

3. Fetal Nigral Transplantation in Parkinson’s Disease

   • Robert A. Hauser, C. Warren Olanow, Barry J. Snow, Thomas B. Freeman

   Pages 19-30

4. Toward a Phase III Multicenter Study of Fetal Ventral Mesencephalic Transplants in Patients with Late-Stage Parkinson’s Disease

   • Marc Peschanski, Gilles Defer, Sophie Dethy, Philippe Hantraye, Marc Levivier, Jean-Paul Nguyen et al.

   Pages 31-43

5. PET Studies of Transplantation Therapy

   • Barry J. Snow

   Pages 45-50

6. Neuropathology of Dopaminergic Transplants in Patients with Parkinson’s Disease

   • Jeffrey H. Kordower, Rose Hanbury, Krzysztof S. Bankiewicz

   Pages 51-75

7. Fetal-Tissue Transplantation for Huntington’s Disease: Preclinical Studies

   • Paul R. Sanberg, Cesario V. Borlongan, Klas Wictorin, Ole Isacson

   Pages 77-93

8. Fetal Transplantation for Huntington’s Disease: Clinical Studies

   • O. V. Kopyov, S. Jacques, M. Kurth, L. Philpott, A. Lee, M. Patterson et al.

   Pages 95-134

9. Topographic Factors Affecting the Functional Viability of Dopamine-Rich Grafts in the Neostriatum

   • Stephen B. Dunnett, Barry J. Everitt

   Pages 135-169

10. Immunological Issues in Rodent and Primate Transplants (Allografts)

    • Håkan Widner

    Pages 171-187

11. Transplanting Fetal Neural Xenogeneic Cells in Parkinson’s and Huntington’s Disease Models

    • Ole Isacson, Peyman Pakzaban, Wendy R. Galpern

    Pages 189-210

12. Animal Models of Cerebral Ischemia

    • Cesario V. Borlongan, Toru Shimizu, John Q. Trojanowski, Shigeru Watanabe, Virginia M.-Y. Lee, Yasuo Tajima et al.

    Pages 211-230

13. Transplantation Strategies for the Treatment of Pain

    • Jacqueline Sagen

    Pages 231-251

14. Treatment of Central Nervous System Diseases with Polymer-Encapsulated Xenogeneic Cells

    • Dwaine F. Emerich, Mark D. Lindner, Joel Saydoff, Frank T. Gentile

    Pages 253-286

15. Transplant Strategies in Myelin Disorders

    • Ian D. Duncan

    Pages 287-302

16. Somatic Gene Transfer and Cell Transplantation Strategies for Neurodegenerative Diseases

    • Silke Thode, Heather K. Raymon, Fred H. Gage

    Pages 303-331

17. Adequately Respecting and Protecting Fetal Tissue Donors and Their Next-of-Kin

    • Dorothy E. Vawter, Karen G. Gervais

    Pages 333-338

18. Back Matter

    Pages 339-350

    PDF

Distinguished medical researchers from around the world review novel neural reconstructive techniques that appear to be beneficial for Parkinson's disease and hold promise for treating Huntington's disease, pain, demyelinating diseases, and stroke. The contributors focus on those diseases for which clinical trials are either ongoing or likely to occur in the near future. Among the topics reviewed are results and rationale for some of the leading transplant programs for the treatment of Parkinson's disease, the use of PET scanning for patient evaluation, autopsy studies of transplant recipients, transplant immunology, fetal tissue transplantation for Huntington's disease, cellular transplantation for the treatment of pain and stroke, and transplantation of myelinating cells. A full discussion of the important ethical issues surrounding the use of fetal tissue for transplantation purposes is also included.

• Nervous System
• PET
• Parkinson
• central nervous system
• cerebral ischemia
• neuropathology
• parkinson's disease
• positron emission tomography (PET)
• stroke
• tissue
• transplantation

"The list of contributors reads like a "who's who" in neural transplantation. . .The chapters are generally well-written, logically arranged, and overall the book is a joy to read. . .this is a truly outstanding book, very well written by the leading authorities. It provides a solid basis of knowledge and understanding in this rapidly developing field. . . Not only neuroscientists, but every neurologists, neurosurgeon, and probably many internists may find this book interesting and relevant to the future of their practice. This book should be found in every medical library."-Archives of Neurology

"The editors. . .have gathered an international panel of experts to address the preclinical foundations fro human trials. . .this is an accomplished work."-Neurology

"This book is a statement-of-the-state of the art in neurotransplantation therapy....The book is a good mix of clinical and basic scientific information and was quite enjoyable to read. It establishes that transplantation therapy will have an ever increasing role in the treatment of neurologic conditions. It points out the obstacles ahead and the challenges that must be faced in the future. It should be on every functional neurosurgeon's and neurologist's bookshelf."-Le Journal Canadien des Sciences Neurologiques

"...these chapters are excellent, and give timely perspective and rationale for the development of neurotransplantation....The chapters are well written, logically arranged, and well documented....this excellent book by experts in the field provides great insight for anyone interested in neurological disease. Some of the information in this volume has not been published, and it represents a unique resource. This is an extremely rapidly developing field, and the book will allow readers to quickly understand the importance and breath of the field." -Quarterly Review of Biology

• Division of Neurosurgery, Department of Pharmacology and Experimental Therapeutics, The Neuroscience Program, University of South Florida, Tampa, USA

  Thomas B. Freeman

• Departments of Clinical Neurosciences and Physiology and Neuroscience, Wallenberg Neuroscience Center, Lund University, Lund, Sweden

  Håkan Widner

Policies and ethics