Neuroprotective Signal Transduction

1. Front Matter

   Pages i-x

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2. Neuroprotective Strategies Involving the Neurotrophins and Their Signaling Pathways

   • Joe E. Springer, Patrick H. Kitzman

   Pages 1-21

3. Nerve Growth Factor and Its Receptors in the Primate Forebrain

   • Elliott J. Mufson, J. H. Kordower

   Pages 23-59

4. Molecular Mechanisms of Neuroprotection from Neuronal Death by Trophic Factor Deprivation

   • Thomas L. Deckwerth

   Pages 61-82

5. Gene Induction and Neuronal Apoptosis

   • Steve Estus

   Pages 83-94

6. Clinical Potential of Compounds That Stimulate Nerve Growth Factor Production

   • Atsumi Nitta, Shoei Furukawa, Toshitaka Nabeshima

   Pages 95-110

7. Preclinical Trials of Basic Fibroblast Growth Factor (bFGF) in Animal Models of Stroke

   • Ilknur Ay, Seth P. Finklestein

   Pages 111-118

8. Transforming Growth Factor-β Signaling and Neuroprotection

   • Kerstin Krieglstein, Josef Krieglstein

   Pages 119-144

9. Protective and Regenerative Properties of GDNF in the Central Nervous System

   • Wayne A. Cass, Cecilia M. Kearns, Don M. Gash

   Pages 145-161

10. Tumor Necrosis Factor

    • Steven W. Barger

    Pages 163-183

11. Neuroprotective Strategies Based on Interleukin Signaling

    • David Martin, Gerald Miller, Norman Fischer

    Pages 185-195

12. Signaling by β-Amyloid Precursor Protein

    • Katsutoshi Furukawa

    Pages 197-220

13. Clinical Potential of Agents That Affect Thrombin Signaling in Degenerative and Traumatic Neurologic Disorders

    • Barry W. Festoff

    Pages 221-241

14. Thrombin and Thrombin Inhibitors

    • Virginia L. Smith-Swintosky

    Pages 243-258

15. Deleterious and Salutary Effects of Steroid Hormones in the Nervous System

    • Robert M. Sapolsky

    Pages 259-283

16. Therapeutic Potential of Leukocyte Antiadhesion Strategies in CNS Ischemia

    • Wayne M. Clark, Justin A. Zivin

    Pages 285-299

17. Neuroprotective Strategies Based on Targeting of Postreceptor Signaling Events

    • Mark P. Mattson

    Pages 301-335

18. Back Matter

    Pages 337-347

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In Neuroprotective Signal Transduction prominent researchers and clinicians focus on how inter- and intracellular signaling mechanisms prevent the degeneration and death of neurons occurring in both acute and chronic neurodegenerative disorders. Authoritative contributions dissect the signaling pathways of an array of neuroprotective factors-ranging from neurotrophins (NGF, BDNF, NT-3, and NT-4/5), to growth factors (bFGF, IGF-1, GDNF), to cytokines (TNF, IL-1b, and TGFb), to secreted amyloid precursor proteins, to protease nexin-1. Also treated are cytoprotective signaling events that occur within injured neurons independently of intercellular signals. Neuroprotective Signal Transduction presents fundamental, cutting-edge treatment of the cellular and molecular signal transduction pathways found in human neurodegenerative conditions. The book's elucidation of the molecular cascades evolved by the nervous system to protect itself is now lead to effective strategies for preventing neuronal degeneration in such conditions as stroke, traumatic brain injury, Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis, and will form the basis for powerful new drug discovery and gene therapy strategies.

• Deprivation
• Nervous System
• Parkinson
• cellular mechanisms
• forebrain
• genes
• molecular mechanisms
• neurons
• proteins
• signal transduction

• University of Kentucky, Lexington, USA

  Mark P. Mattson

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