Clinical Pharmacology of Cerebral Ischemia

1. Front Matter

   Pages i-x

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2. Stroke

   • Gert J. Ter Horst, Antonio Postigo

   Pages 1-30

3. Imaging of Stroke

   • Henk Stevens, Hugo M. L. Jansen, Jacques DeReuck, Jakob Korf

   Pages 31-41

4. Clinical Aspects of Stroke and Therapeutic Strategies

   • Keith W. Muir, Elkan Gamzu, Kennedy R. Lees

   Pages 43-66

5. Calcium Homeostasis, Nimodipine, and Stroke

   • Paul G. M. Luiten, Bauke Stuiver, Gineke I. de Jong, Csaba Nyakas, Jacques H. A. De Keyser

   Pages 67-99

6. Glutamate Neurotoxicity and Stroke

   • Tihomir P. Obrenovitch

   Pages 101-125

7. Glycine Antagonists for Treatment of Ischemic Brain Injury

   • Midori A. Yenari, David C. Tong, Gregory W. Albers

   Pages 127-151

8. Free Radical-Mediated Cerebral Damage After Hypoxia/Ischemia and Stroke

   • Tomohiro Matsuyama

   Pages 153-184

9. Genomic Responses Following Cerebral Ischemia

   • Christoph Wiessner, Konstantin-Alexander Hossmann

   Pages 185-213

10. Hormonal Modulators of Cerebral Ischemia

    • Laura J. McIntosh, Robert M. Sapolsky

    Pages 215-234

11. Inflammatory Responses to Cerebral Ischemia

    • John Sharkey, John S. Kelly, Steven P. Butcher

    Pages 235-263

12. Animal Models Used in Cerebral Ischemia and Stroke Research

    • Akira Tamura, Kensuke Kawai, Kiyoshi Takagi

    Pages 265-294

13. Back Matter

    Pages 295-305

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A distinguished international panel of authors define our current understanding of neuronal damage after ischemia and critically review the significant recent developments and progress in cerebrovascular accident (CVA) drug trials, both in animal models and in the clinical setting. These leading basic and fundamental authorities survey such important new drugs as calcium-influx inhibitors, free-radical scavenging drugs, glutamate and glycinergic antagonists, and immune suppressors. They also evaluate all the latest findings concerning calcium homeostasis, glutamate toxicity, gene activation, and the role of free radicals, glycine, and hormones. Chapters devoted to the neuroimaging of stroke, clinical trials, and the role of cerebral immune activation complete this informative collection of cutting-edge reviews.

• brain
• brain injury
• calcium
• cerebral ischemia
• clinical trial
• death
• drug
• hypoxia
• neuroimaging
• neurotoxicity
• research
• stroke
• toxicity

". . .the new standard reference work for neurologists and neurosurgeons treating patients with CVA."-Trends in Neuroscience

• Department of Biological Psychiatry, Groningen Center for Behavioral and Cognitive Neurosciences, University of Groningen, The Netherlands

  Gert J. Horst, Jakob Korf

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