Neurotherapeutics

1. Front Matter

   Pages i-x

   PDF

2. Schizophrenia Treatment Strategies

   • Herbert Y. Meltzer

   Pages 1-34

3. Affective Disorders

   • Husseini K. Manji, William Z. Potter

   Pages 35-83

4. Anxiety and Panic Disorders

   • Helen C. Jackson, David J. Nutt

   Pages 85-131

5. Acute and Chronic Disease

   • Carlos R. Plata-Salamán

   Pages 133-166

6. Opioids and the Control of Pain

   • Dennis Paul, Gavril W. Pasternak

   Pages 167-192

7. Epilepsy

   • Michael A. Rogawski

   Pages 193-273

8. Neuroprotective Strategies for Treatment of Acute Ischemic Stroke

   • Linda M. Pullan

   Pages 275-322

9. Huntington’s Disease

   • Shutish C. Patel, Kamlesh Asotra, Yogesh C. Patel

   Pages 323-342

10. Parkinson’s Disease

    • Barbara Stauch Slusher, Paul F. Jackson, Lisa A. Arvanitis

    Pages 343-388

11. Alzheimer’s Disease

    • Robert Siman, Barry D. Greenberg

    Pages 389-428

12. Back Matter

    Pages 429-434

    PDF

Neuroscience's inherent complexity and rapid growth mean that no one can keep abreast of all the changes across the field. We each bring a necessarily narrow perspective. Neurotherapeutics: Emerg­ ing Strategies is an attempt to provide some diverse perspectives within the hunt for new drugs to treat central nervous system diseases. The book's premise is that the search for new drugs is based on an understanding ofboth clinical and basic sciences. Neurotherapeu­ tics: Emerging Strategies begins with psychiatry and concludes with neurological disorders. Each chapter examines a disease, including clinical features and existing treatments, but the emphasis is on current concepts of underlying causes and novel strategies for drug discovery arising from these possible mechanisms. Participating authors include basic neuroscientists, industry-based pharmacolo­ gists and chemists, and clinicians. The chapters describe the status of the existing disease treat­ ments, and when treatments are lacking, the approach is more basic science oriented. When there is a long history of treatment, there is greater emphasis on those therapies. However, all the chapters seem to reflect the benefits of cloning, since the availability of receptor subtypes now promises the opportunity for greater specificity of drug effects. Modulation of second messengers is another new and recur­ ring theme. And in the chapter on cachexia, cytokines are explored both as drugs and drug targets. Neurotherapeutics: Emerging Strategies reflects the complex­ ity of the nervous system, but the overriding message is hope for new and better drugs to treat those diseases that rob us of ourselves.

• Alzheimer
• Nervous System
• Parkinson
• alzheimer's disease
• cytokine
• drug
• drug discovery
• neuroscience
• opioid
• pathophysiology
• physiology
• psychiatry
• receptor
• research
• schizophrenia

...would be of use to the clinician wanting a better understanding of current research approaches in the neurosciences or to the basic scientist wanting a quick update on areas beyond their expertise.-Journal of Medicinal Chemistry

• Department of Pharmacology, Zeneca Pharmaceuticals Group, Wilmington, USA

  Linda M. Pullan, Jitendra Patel

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