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Antiangiogenic Agents in Cancer Therapy

  • Book
  • © 1999

Overview

Editors:
  1. Beverly A. Teicher

    1. Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, USA

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Part of the book series: Cancer Drug Discovery and Development (CDD&D)

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Table of contents (25 chapters)

  1. Front Matter

    Pages i-xi
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  2. Antiangiogenic Factors and Tumor Vasculature

    1. Front Matter

      Pages 1-1
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    2. Angiogenesis and Oxygen Transport in Solid Tumors

      • Zishan A. Haroon, Kevin G. Peters, Charles S. Greenberg, Mark W. Dewhirst
      Pages 3-21

    3. Oxygenation of Solid Tumors in Animals and Patients

      • Eric Lartigau, Marcelle Guichard
      Pages 23-35

    4. Role of Inflammatory Mediators in Angiogenesis

      • Federico Bussolino, Alberto Mantovani
      Pages 37-50

    5. Intra- and Extracellular pH in Solid Tumors

      • Chang W. Song, HeonJoo Park, Brian D. Ross
      Pages 51-64

    6. Contribution of the Extracellular Matrix and Macrophages in Angiogenesis

      • Peter J. Polverini
      Pages 65-75

    7. Regulation of Angiogenesis by the Organ Microenvironment

      • Diane R. Bielenberg, Isaiah J. Fidler
      Pages 77-91

    8. Fibroblast Growth Factors in Tumor Progression and Angiogenesis

      • Israel Vlodavsky, Gerhard Christofori
      Pages 93-118

    9. Role of Vascular Endothelial Growth Factor in Regulation of Angiogenesis

      • Napoleone Ferrara
      Pages 119-141

    10. Regulatory Aspects of Neovascularization

      • M. Zamirul Hussain, Q. Perveen Ghani, John J. Feng, Thomas K. Hunt
      Pages 143-150

  3. Antiangiogenic Agents

    1. Front Matter

      Pages 151-151
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    2. Squalamine

      • Jon I. Williams
      Pages 153-174

    3. Cartilage as a Source of Natural Inhibitors of Angiogenesis

      • Vincent Castronovo, Violetta Dimitriadou, Pierre Savard, Marc Rivière, Eric Dupont
      Pages 175-183

    4. Thrombospondin as an Inhibitor of Angiogenesis

      • David W. Dawson, Noël P. Bouck
      Pages 185-203

    5. Matrix Metalloproteinase Inhibitors

      • Peter D. Brown, Mark Whittaker
      Pages 205-223

    6. Angiostatin Protein and Other Plasminogen Fragments

      • B. Kim Lee Sim
      Pages 225-236

    7. Dietary and Nutritional Modulation of Tumor Angiogenesis

      • Purna Mukherjee, Jin-Rong Zhou, Alexander V. Sotnikov, Steven K. Clinton
      Pages 237-261

    8. Thalidomide and Analogs

      • Taturo Udagawa, Henk M. W. Verheul, Robert J. D’Amato
      Pages 263-274

  4. In Vivo Studies and Clinical Trials

    1. Front Matter

      Pages 275-275
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Keywords

About this book

Beverly Teicher and a panel of distinguished investigators survey the state-of-the-art of antiangiogenesis research from the lab bench to clinical trials. Timely and authoritative, the contributors summarize our current understanding of tumor growth and its dependence on vascular development, as well as the present status of antiangiogenic agents in preclinical and clinical development. In addition, the book also examines what is known about the mechanisms by which these therapeutic agents interfere with tumor vasculature and grapples with the problem of establishing criteria by which to assess their clinical efficacy. Antiangiogenic Agents in Cancer Therapy offers a unique cutting-edge compendium of antiangiogenic research, taking stock of what has been accomplished , where the experimental therapeutics of antiangiogenic agents is going, and the continuing evolution of their role in cancer treatment and novel drug development.


Editors and Affiliations

  • Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, USA

    Beverly A. Teicher

Bibliographic Information

  • Book Title: Antiangiogenic Agents in Cancer Therapy

  • Editors: Beverly A. Teicher

  • Series Title: Cancer Drug Discovery and Development

  • DOI: https://doi.org/10.1007/978-1-59259-453-5

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1999

  • eBook ISBN: 978-1-59259-453-5Published: 28 December 1998

  • Series ISSN: 2196-9906

  • Series E-ISSN: 2196-9914

  • Edition Number: 1

  • Number of Pages: XI, 450

  • Number of Illustrations: 36 b/w illustrations, 1 illustrations in colour

  • Topics: Oncology, Surgical Oncology, Cancer Research

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