Overview
- Editors:
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Sukriti Nag
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Division of Neuropathology, University of Toronto, Toronto, Canada
Toronto Western Research Institute and Department of Pathology, University Health Network, Toronto, Canada
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Table of contents (36 protocols)
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Front Matter
Pages i-xiii
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Tissue Techniques
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- Hartwig Wolburg, Stefan Liebner, Andrea Lippoldt
Pages 51-66
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- Albert S. Lossinsky, Richard R. Shivers
Pages 67-82
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- Britta Engelhardt, Peter Vajkoczy, Melanie Laschinger
Pages 83-93
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Blood-Brain Barrier Permeability Techniques
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- Eain M. Cornford, Shigeyo Hyman, Marcia E. Cornford
Pages 161-175
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- Kamlesh Asotra, Nagendra Ningaraj, Keith L. Black
Pages 177-190
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Blood-Brain Barrier Transport Techniques
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Front Matter
Pages 191-191
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- Quentin R. Smith, David D. Allen
Pages 209-218
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- Hiroyuki Kusuhara, Tetsuya Terasaki, Yuichi Sugiyama
Pages 219-231
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- Darryl R. Peterson, Richard A. Hawkins
Pages 233-247
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- Haiqing Dai, William F. Elmquist
Pages 249-264
About this book
Blood–brain barrier (BBB) breakdown leading to cerebral edema occurs in many brain diseases—such as trauma, stroke, inflammation, infection, and tumors—and is an important factor in the mortality arising from these con- tions. Despite the importance of the BBB in the pathogenesis of these diseases, the molecular mechanisms occurring at the BBB are not completely und- stood. In the last decade a number of molecules have been identified not only in endothelial cells, but also in astrocytes, pericytes, and the perivascular cells that interact with endothelium to maintain cerebral homeostasis. However, the precise cellular interactions at a molecular level in steady states and d- eases have still to be determined. The introduction of new research techniques during the last decade or so provide an opportunity to study the molecular mec- nisms occurring at the BBB in diseases. The Blood–Brain Barrier: Biology and Research Protocols provides the reader with details of selected morphologic, permeability, transport, in vitro, and molecular techniques for BBB studies, all written by experts in the field. Each part is preceded by a review that emphasizes the advantages and pitfalls of particular techniques, as well as offering much relevant current information. The techniques provided will be helpful to both beginners in BBB research and those more experienced investigators who wish to add a specific technique to those already available in their laboratories.
Reviews
"An outstanding addition to the field! The book is unique in its organization and ease of reading and use as research resource. In my view, this book will emerge as one of the more cited and critical sources of information for all researchers exploring the nature of the blood-brain barrier."-Doody's Health Science Book Review Journal
Editors and Affiliations
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Division of Neuropathology, University of Toronto, Toronto, Canada
Sukriti Nag
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Toronto Western Research Institute and Department of Pathology, University Health Network, Toronto, Canada
Sukriti Nag
