Stem Cells Handbook

1. Front Matter

   Pages i-xiii

   PDF

2. Stem Cells

   • Stewart Sell

   Pages 1-18

3. Stem Cells from Early Mammalian Embryos

   • Virginia E. Papaioannou, Anna-Katerina Hadjantonakis

   Pages 19-31

4. Embryonic Stem Cells

   • Joy Rathjen, Peter David Rathjen

   Pages 33-43

5. From Stem Cells to Functional Tissue Architecture

   • Sui Huang, Donald E. Ingber

   Pages 45-56

6. Germline Stem Cells

   • Haifan Lin

   Pages 57-73

7. Stem Cells and Cloning

   • Ian Wilmut, Lesley Ann Paterson

   Pages 75-80

8. Genomic Imprinting in Mouse Embryonic Stem and Germ Cells

   • Jeffrey R. Mann, Piroska E. Szabó

   Pages 81-88

9. Stem Cells in Amphibian Regeneration

   • David L. Stocum

   Pages 89-100

10. Stem Cells in Dermal Wound Healing

    • William J. Lindblad

    Pages 101-105

11. Bone Marrow Mesenchymal Stem Cells

    • James E. Dennis, Arnold I. Caplan

    Pages 107-117

12. Normal and Leukemic Hematopoietic Stem Cells and Lineages

    • Ernest A. McCulloch

    Pages 119-131

13. Developmental Origin of Murine Hematopoietic Stem Cells

    • Lorraine Robb, Kyunghee Choi

    Pages 133-142

14. Stromal Support of Hematopoiesis

    • Pierre Charbord

    Pages 143-154

15. Hematopoietic Stem Cells

    • Ian Ponting, Yi Zhao, W. French Anderson

    Pages 155-161

16. Hematopoietic Stem Cells in Leukemia and Lymphoma

    • Stephen M. Baird

    Pages 163-175

17. Neurons, Stem Cells and Potential Therapies

    • Fiona C. Mansergh, Michael A. Wride, Derrick E. Rancourt

    Pages 177-189

18. Neural Stem Cells

    • Michael A. Marconi, Kook I. Park, Yang D. Teng, Jitka Ourednik, Vaclav Ourednik, Rosanne M. Taylor et al.

    Pages 191-208

19. Molecular Genetic Approaches in the Study of Retinal Progenitor Cells and Stem Cells

    • Till Marquardt, Peter Gruss

    Pages 209-219

20. Endothelial Progenitor Cells

    • Takayuki Asahara, Jeffrey M. Isner

    Pages 221-227

The power of stem cells for tissue development, regeneration, and renewal has been well known by embryologists and developmental biologists for many years. Those presently active in research in the stem cell field owe much to previous work by embryologists and cancer researchers for their insights into what stem cells can do. In the last 4- 5 years, the rapid expansion of the concept of adult tissue stem cells as pluripotent progenitors for various tissues has led to an even greater appreciation of the power of stem cells. The demonstration that both embryonic and adult tissue stem cells have the ability to produce progenitor cells for tissue renewal has opened vast possibilities for treatment of congenital deficiency diseases as well as for regeneration of damaged tissues. Older concepts of determination leading to loss of potential during differentiation of adult tissues are being replaced by newer ideas that cells with multiple potential exist in different forms in various adult organs and that cells thought to be restricted to differentiation to one cell type may be able to "transdifferentiate" into other tissue cell types. Thus, the concept of "embryonic rests" in adult tissues, hypothesized to be the cellular origin of cancer by Durante and Conheim in the 1870s, now can be expanded to include survival of pluripotential embryonic-like stem cells in adult tissues.

• Vivo
• cell biology
• mammalian embryos
• tissue
• transcription

"Truly outstanding descriptions of the fields of early mammalian development, DNA methylation, neural stem cell biology, and imaging technologies help round the reader's knowledge through the use of perspicuous language and concepts." - Developmental Cell

• Wadsworth Center and Ordway Research Institute, Albany, USA

  Stewart Sell

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