Overview
- Editors:
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Stewart Sell
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Wadsworth Center and Ordway Research Institute, Albany, USA
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Table of contents (43 chapters)
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Front Matter
Pages i-xiii
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- Virginia E. Papaioannou, Anna-Katerina Hadjantonakis
Pages 19-31
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- Joy Rathjen, Peter David Rathjen
Pages 33-43
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- Sui Huang, Donald E. Ingber
Pages 45-56
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- Ian Wilmut, Lesley Ann Paterson
Pages 75-80
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- Jeffrey R. Mann, Piroska E. Szabó
Pages 81-88
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- James E. Dennis, Arnold I. Caplan
Pages 107-117
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- Lorraine Robb, Kyunghee Choi
Pages 133-142
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- Ian Ponting, Yi Zhao, W. French Anderson
Pages 155-161
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- Fiona C. Mansergh, Michael A. Wride, Derrick E. Rancourt
Pages 177-189
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- Michael A. Marconi, Kook I. Park, Yang D. Teng, Jitka Ourednik, Vaclav Ourednik, Rosanne M. Taylor et al.
Pages 191-208
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- Till Marquardt, Peter Gruss
Pages 209-219
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- Takayuki Asahara, Jeffrey M. Isner
Pages 221-227
About this book
The power of stem cells for tissue development, regeneration, and renewal has been well known by embryologists and developmental biologists for many years. Those presently active in research in the stem cell field owe much to previous work by embryologists and cancer researchers for their insights into what stem cells can do. In the last 4- 5 years, the rapid expansion of the concept of adult tissue stem cells as pluripotent progenitors for various tissues has led to an even greater appreciation of the power of stem cells. The demonstration that both embryonic and adult tissue stem cells have the ability to produce progenitor cells for tissue renewal has opened vast possibilities for treatment of congenital deficiency diseases as well as for regeneration of damaged tissues. Older concepts of determination leading to loss of potential during differentiation of adult tissues are being replaced by newer ideas that cells with multiple potential exist in different forms in various adult organs and that cells thought to be restricted to differentiation to one cell type may be able to "transdifferentiate" into other tissue cell types. Thus, the concept of "embryonic rests" in adult tissues, hypothesized to be the cellular origin of cancer by Durante and Conheim in the 1870s, now can be expanded to include survival of pluripotential embryonic-like stem cells in adult tissues.
Reviews
"Truly outstanding descriptions of the fields of early mammalian development, DNA methylation, neural stem cell biology, and imaging technologies help round the reader's knowledge through the use of perspicuous language and concepts." - Developmental Cell
Editors and Affiliations
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Wadsworth Center and Ordway Research Institute, Albany, USA
Stewart Sell