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Cell Cycle Inhibitors in Cancer Therapy

Current Strategies

  • Book
  • © 2003

Overview

Editors:
  1. Antonio Giordano

    1. Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Kenneth J. Soprano

    1. Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Cancer Drug Discovery and Development (CDD&D)

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. Cdk Inhibitors

    • Giulia De Falco, Catherine Soprano, Antonio Giordano
    Pages 1-10

  3. p27, A Prognostic Indicator Reflecting ...?

    • Andrew Koff
    Pages 11-29

  4. Cell Cycle Control of Transcription at the G1/S Phase Transition

    • André J. van Wijnen, Gary S. Stein, Janet L. Stein, Jane B. Lian
    Pages 31-48

  5. Tumor-Suppressor Genes as Diagnostic Tools

    • Lorenzo Leoncini, Cristiana Bellan, Caterina Cinti, Antonio Giordano
    Pages 49-82

  6. Regulation of Cell Cycle and Apoptosis

    • Lucio Miele
    Pages 83-118

  7. CDK Inhibitors as Targets of Chemoprevention Agents

    • Joanna K. Sax, Wafik S. El-Deiry
    Pages 119-143

  8. Cell Cycle Regulatory Genes as Targets of Retinoids

    • Kenneth J. Soprano, Sijie Zhang, Dongmei Zhang, William F. Holmes, Valeria Masciullo, Antonio Giordano et al.
    Pages 145-177

  9. Modulators of Cyclin-Dependent Kinases

    • Adrian M. Senderowicz
    Pages 179-205

  10. Cell Cycle Regulators

    • Paul J. van Diest, Rob J. A. M. Michalides
    Pages 207-252

  11. Cell Cycle Regulators as Targets of Anticancer Therapy

    • Mikhail V. Blagosklonny
    Pages 253-275

  12. Mammalian CDK Inhibitors as Targets of Ubiquitinization in Cancer

    • Valeria Masciullo, Kenneth J. Soprano, Antonio Giordano
    Pages 277-296

  13. Synthetic Oligopeptides as Cancer Cell Cycle Modulators

    • Anna Severino, Armando Felsani, Antonio Giordano, Marco G. Paggi
    Pages 297-310

  14. Back Matter

    Pages 311-326
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Keywords

About this book

Leading clinicians and investigators review in a comprehensible and user-friendly style all the latest information about the molecular biology of cell cycle control and demonstrate its clinical relevance to understanding neoplastic diseases. Topics range from Cdk inhibitors and cell cycle regulators to the prognostic value of p27 and tumor suppressor genes as diagnostic tools. Actual case studies show how the new molecular understanding has produced such drugs as Flavopiridol and Sulindac. The book brings all the recent critical research findings to bear on clinical practice, and clearly shows their powerful impact on the diagnostics, prognostics, and therapeutics of cancer, AIDS, and cardiovascular disease.

Reviews

"Cell Cycle Inhibitors in Cancer Therapy is an excellent book that summarizes the most up-to-date information on cell cycle control mechanisms, the naturally occurring and synthetic molecules that modulate cell cycle events, and their potential roles in cancer therapeutics and prevention." -Pharmaceutical Research

Editors and Affiliations

  • Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, USA

    Antonio Giordano

  • Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, USA

    Kenneth J. Soprano

Bibliographic Information

  • Book Title: Cell Cycle Inhibitors in Cancer Therapy

  • Book Subtitle: Current Strategies

  • Editors: Antonio Giordano, Kenneth J. Soprano

  • Series Title: Cancer Drug Discovery and Development

  • DOI: https://doi.org/10.1007/978-1-59259-401-6

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2003

  • Hardcover ISBN: 978-0-89603-930-8Published: 20 November 2002

  • Softcover ISBN: 978-1-61737-257-5Published: 19 November 2010

  • eBook ISBN: 978-1-59259-401-6Published: 20 November 2002

  • Series ISSN: 2196-9906

  • Series E-ISSN: 2196-9914

  • Edition Number: 1

  • Number of Pages: X, 326

  • Number of Illustrations: 22 b/w illustrations

  • Topics: Oncology, Cancer Research

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