Cell Cycle Inhibitors in Cancer Therapy

1. Front Matter

   Pages i-x

   PDF

2. Cdk Inhibitors

   • Giulia De Falco, Catherine Soprano, Antonio Giordano

   Pages 1-10

3. p27, A Prognostic Indicator Reflecting ...?

   • Andrew Koff

   Pages 11-29

4. Cell Cycle Control of Transcription at the G1/S Phase Transition

   • André J. van Wijnen, Gary S. Stein, Janet L. Stein, Jane B. Lian

   Pages 31-48

5. Tumor-Suppressor Genes as Diagnostic Tools

   • Lorenzo Leoncini, Cristiana Bellan, Caterina Cinti, Antonio Giordano

   Pages 49-82

6. Regulation of Cell Cycle and Apoptosis

   • Lucio Miele

   Pages 83-118

7. CDK Inhibitors as Targets of Chemoprevention Agents

   • Joanna K. Sax, Wafik S. El-Deiry

   Pages 119-143

8. Cell Cycle Regulatory Genes as Targets of Retinoids

   • Kenneth J. Soprano, Sijie Zhang, Dongmei Zhang, William F. Holmes, Valeria Masciullo, Antonio Giordano et al.

   Pages 145-177

9. Modulators of Cyclin-Dependent Kinases

   • Adrian M. Senderowicz

   Pages 179-205

10. Cell Cycle Regulators

    • Paul J. van Diest, Rob J. A. M. Michalides

    Pages 207-252

11. Cell Cycle Regulators as Targets of Anticancer Therapy

    • Mikhail V. Blagosklonny

    Pages 253-275

12. Mammalian CDK Inhibitors as Targets of Ubiquitinization in Cancer

    • Valeria Masciullo, Kenneth J. Soprano, Antonio Giordano

    Pages 277-296

13. Synthetic Oligopeptides as Cancer Cell Cycle Modulators

    • Anna Severino, Armando Felsani, Antonio Giordano, Marco G. Paggi

    Pages 297-310

14. Back Matter

    Pages 311-326

    PDF

Leading clinicians and investigators review in a comprehensible and user-friendly style all the latest information about the molecular biology of cell cycle control and demonstrate its clinical relevance to understanding neoplastic diseases. Topics range from Cdk inhibitors and cell cycle regulators to the prognostic value of p27 and tumor suppressor genes as diagnostic tools. Actual case studies show how the new molecular understanding has produced such drugs as Flavopiridol and Sulindac. The book brings all the recent critical research findings to bear on clinical practice, and clearly shows their powerful impact on the diagnostics, prognostics, and therapeutics of cancer, AIDS, and cardiovascular disease.

• AIDS
• apoptosis
• cancer
• cancer therapy
• cardiovascular disease
• cell
• diagnostics
• molecular biology
• prevention
• research
• tumor

"Cell Cycle Inhibitors in Cancer Therapy is an excellent book that summarizes the most up-to-date information on cell cycle control mechanisms, the naturally occurring and synthetic molecules that modulate cell cycle events, and their potential roles in cancer therapeutics and prevention." -Pharmaceutical Research

• Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, USA

  Antonio Giordano

• Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, USA

  Kenneth J. Soprano

Policies and ethics