Overview
- Editors:
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Sabire Özcan
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Department of Molecular and Cellular Biochemistry, University of Kentucky Medical College, Lexington
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Table of contents (20 protocols)
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Insulin Production
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- Colleen B. Kelly, Libby A. Blair, John A. Corbett, Anna L. Scarim
Pages 3-14
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- Geert Stangé, Mark Van De Casteele, Harry Heimberg
Pages 15-22
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- Marcela Brissova, Wendell E. Nicholson, Masakazu Shiota, Alvin C. Powers
Pages 23-45
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- Susan C. Campbell, Wendy M. Macfarlane
Pages 47-49
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- Susan C. Campbell, Wendy M. Macfarlane
Pages 51-59
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- Marcelina Párrizas, Sylvia F. Boj, Reini F. Luco, Miguel Angel Maestro, Jorge Ferrer
Pages 61-71
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- Amber L. Mosley, Sabire Özcan
Pages 73-79
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- Dennis G. Karounos, Susan E. Goes
Pages 81-90
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Insulin Action
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- Shuichi Okada, Masatomo Mori, Jeffrey E. Pessin
Pages 93-96
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- Jaganathan Lakshmanan, Jeffrey S. Elmendorf, Sabire özcan
Pages 97-103
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- John B. Knight, Ann Louise Olson
Pages 113-118
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- Eileen L. Whiteman, Morris J. Birnbaum
Pages 119-126
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- Li-Ping Wang, Scott A. Summers
Pages 127-136
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- Kyle L. Hoehn, Scott A. Summers
Pages 137-144
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About this book
Diabetes mellitus is the collective name for a group of diseases associated with hyperglycemia (high levels of blood glucose) caused by defects in insulin p- duction, insulin action, or both. About 6. 2% of the US population (17 million people) have diabetes mellitus. It is the leading cause of kidney failure, bli- ness, and amputations. It is also a major risk factor for heart diseases, stroke, and birth defects. Diabetes Mellitus: Methods and Protocols provides a state-of-the-art account of the experimental methodology for studying the molecular defects leading to diabetes mellitus, both at the molecular and biochemical levels. The chapters cover a wide range of topics written by experts in their respective fields and are organized in two sections: Insulin Production and Insulin Action. The detailed experimental protocols presented, including the notes of interest, provide a very useful tool for basic researchers and clinicians for investigating and treating this disease. Each chapter starts with an introduction to a specific technique and explains its application in the field of diabetes research. Following the list of materials, a detailed description of the technique is presented in the methods section in a way that enables the successful execution of the protocol. The “Notes” section at the end discusses the pitfalls of the technique and alternative approaches. I am grateful to the numerous scientists who have contributed to this volume by writing both highly detailed and understandable chapters.
Reviews
"This book provides all the critical tools needed for the productive study of diabetes mellitus today." - Clinical Laboratory International
"Each chapter/protocol is well referenced and the book is indexed. Because Diabetes Mellitus: Methods and Protocols provides all the critical tools needed for the productive study of diabetes mellitus, it is a necessary purchase for libraries supporting basic research programs that study the molecular and biochemical bases of diabetes mellitus." -E-STREAMS
Editors and Affiliations
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Department of Molecular and Cellular Biochemistry, University of Kentucky Medical College, Lexington
Sabire Özcan
