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Genetics and Genomics of Neurobehavioral Disorders

  • Book
  • © 2003

Overview

Editors:
  1. Gene S. Fisch

    1. Division of Biostatistics, Department of Epidemiology and Public Health and the Child Study Center, Yale University School of Medicine, New Haven, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Contemporary Clinical Neuroscience (CCNE)

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-x
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  2. Introduction and Overview

    1. Front Matter

      Pages 1-1
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    2. The Genetics and Genomics of Neurobehavioral Disorders

      • Gene S. Fisch
      Pages 3-19

    3. Neuroanatomical Considerations Specific to the Study of Neurogenetics

      • Albert M. Galaburda, J. Eric Schmitt
      Pages 21-37

    4. Modeling Cognitive Disorders

      • Rui M. Costa, Ype Elgersma, Alcino J. Silva
      Pages 39-68

    5. What Can the Study of Behavioral Phenotypes Teach Us About the Pathway from Genes to Behavior?

      • Jonathan Flint
      Pages 69-93

  3. Autosomal Disorders and Neurobehavioral Dysfunction

    1. Front Matter

      Pages 95-95
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    2. The Central Nervous System in Neurofibromatosis Type 1

      • Nancy Ratner, Kathryn North
      Pages 97-131

    3. Prader-Willi and Angelman Syndromes

      • Elisabeth M. Dykens, Suzanne B. Cassidy
      Pages 133-158

    4. Tuberous Sclerosis

      • Julian R. Sampson, Julia C. Lewis
      Pages 159-194

    5. Behavioral Phenotype in Velo-Cardio-Facial Syndrome

      • Kieran C. Murphy
      Pages 195-208

    6. Williams-Beuren Syndrome

      • Mònica Bayés, Luis A. Pérez Jurado
      Pages 209-236

    7. Behavioral Phenotype in Myotonic Dystrophy (Steinert’s Disease)

      • Jean Steyaert
      Pages 237-260

  4. X-Linked Nonsyndromal Disorders and Neurobehavioral Dysfunction

    1. Front Matter

      Pages 261-261
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    2. Genetics of X-Linked Mental Retardation

      • Jamel Chelly, Ben C. J. Hamel
      Pages 263-287

    3. Nonsyndromal Mental Retardation Associated with the FRAXE Fragile Site and the FMR2 Gene

      • Jozef Gécz, Gene S. Fisch
      Pages 289-305

  5. X-Linked Syndromal Disorders and Neurobehavioral Dysfunction

    1. Front Matter

      Pages 307-307
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    2. ATR-X Syndrome

      • Takahito Wada, Richard J. Gibbons
      Pages 309-334

    3. The Fragile X Syndrome and the Fragile X Mutation

      • Mark C. Hirst, Gene S. Fisch
      Pages 335-389

    4. Rett Syndrome

      • Alan K. Percy, Joanna Dragich, N. Carolyn Schanen
      Pages 391-418
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Keywords

About this book

In recent years, significant gains have been made in the cloning and identification of numerous genes that produce neurobehavioral disorders, as well as in the ability of neuropsychological tests to accurately assess and evaluate cognitive deficits and behavioral dysfunction. In Genetics and Genomics of Neurobehavioral Disorders, a panel of leading researchers draws on this new knowledge to provide a clear and comprehensive account of how genetic abnormalities, neurobiology, and neuropsychology work together to manifest cognitive-behavioral dysfunction. The authors review the current status of research in autosomal disorders that produce such dysfunctions, examining both microdeletion disorders (Prader-Willi syndrome/Angelman syndrome, deletion 22q11, and Williams syndrome) and syndromes arising from microdeletions and sequence variants, among them neurofibromatosis (NF1 and NF2), tuberous sclerosis (TSC1 and TSC2), and myotonic dystrophy. X-linked disorders producing mental retardation in syndromal disorders (ATRX, Rett, and fragile X) and nonsyndromal disorders (FRAXE and MRX) are also discussed. An insightful introduction surveys the history of neurobehavioral disorders, the establishment of relationships between genetic and cognitive impairment, the relationship between neurobiology and behavior, recent advances in neurogenomics, and the use of animal models for complex human disorders and cognitive impairment.
Comprehensive and up-to-date, Genetics and Genomics of Neurobehavioral Disorders integrates the molecular, genomic, neuropsychological, and neurobehavioral factors that produce learning disabilities and mental retardation into a coherent framework for the understanding and assessment of neurobehavioral disorders.

Reviews

"this book brings together research from neuroscience, genetics, and psychology in a concise and unique way. This type of synthesis is sorely needed as we struggle to understand the complexities of human brain function and dysfunction. It is a valuable contribution to these fields as is, and it is exciting to speculate what future editions will contain. "-Doody's Health Sciences Book Review Journal

"...Gene Fisch has edited a remarkable volume...I highly recommend this book for clinicians, researchers, and students interested in neurodevelopmental disorders." - Human Genetics

"...a comprehensive and highly accessible review of this enormously interesting body of work...a highly readable and thought-provoking volume." - J. AM. ACAD. CHILD ADOLESC. PSYCHIATRY

"...a useful update on behavioral phenotypes for which the neurobiological substrates are beginning to reveal their secrets." - Association for Child Psychology

"...a useful update on behavioral phenotypes for which the neurobiological substrates are beginning to reveal their secrets." - Journal of Child Psychology and Psychiatry

Editors and Affiliations

  • Division of Biostatistics, Department of Epidemiology and Public Health and the Child Study Center, Yale University School of Medicine, New Haven, USA

    Gene S. Fisch

Bibliographic Information

  • Book Title: Genetics and Genomics of Neurobehavioral Disorders

  • Editors: Gene S. Fisch

  • Series Title: Contemporary Clinical Neuroscience

  • DOI: https://doi.org/10.1007/978-1-59259-353-8

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2003

  • Hardcover ISBN: 978-1-58829-045-8Published: 07 January 2003

  • Softcover ISBN: 978-1-61737-322-0Published: 09 November 2010

  • eBook ISBN: 978-1-59259-353-8Published: 07 January 2003

  • Series ISSN: 2627-535X

  • Series E-ISSN: 2627-5341

  • Edition Number: 1

  • Number of Pages: X, 428

  • Number of Illustrations: 27 b/w illustrations

  • Topics: Human Genetics

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