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Molecular Biology of Drug Addiction

  • Book
  • © 2003

Overview

Editors:
  1. Rafael Maldonado

    1. Laboratory of Neuropharmacology Health and Life Sciences School, Universitat Pompeu Fabra, Barcelona, Spain

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-x
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  2. Opioid Addiction

    1. Front Matter

      Pages 1-1
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    2. Molecular Mechanisms of Opioid Dependence by Using Knockout Mice

      • Brigitte L. Kieffer, Frédéric Simonin
      Pages 3-25

    3. Molecular Genetic Approaches

      • Theo Mantamadiotis, Günther Schütz, Rafael Maldonado
      Pages 27-36

    4. Opiate Addiction Role of cAMP Pathway and CREB

      • Lisa M. Monteggia, Eric J. Nestler
      Pages 37-44

    5. Different Intracellular Signaling Systems Involved in Opioid Tolerance/Dependence

      • Thomas Koch, Stefan Schulz, Volker Höllt
      Pages 45-60

    6. Inhibitors of Enkephalin Catabolism

      • Florence Noble, Bernard P. Roques
      Pages 61-75

  3. Psychostimulant Addiction

    1. Front Matter

      Pages 77-77
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    2. Recent Advances in the Molecular Mechanisms of Psychostimulant Abuse Using Knockout Mice

      • Cécile Spielewoy, Bruno Giros
      Pages 79-106

    3. Opioid Modulation of Psychomotor Stimulant Effects

      • Toni S. Shippenberg, Vladimir I. Chefer
      Pages 107-132

    4. Influence of Environmental and Hormonal Factors in Sensitivity to Psychostimulants

      • Michela Marinelli, Pier Vincenzo Piazza
      Pages 133-159

    5. Development and Expression of Behavioral Sensitization

      • Peter W. Kalivas
      Pages 161-169

  4. Cannabinoid Addiction

    1. Front Matter

      Pages 171-171
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    2. New Advances in the Identification and Physiological Roles of the Components of the Endogenous Cannabinoid System

      • Ester Fride, Raphael Mechoulam
      Pages 173-197

    3. Integration of Molecular and Behavioral Approaches to Evaluate Cannabinoid Dependence

      • Dana E. Selley, Aron H. Lichtman, Billy R. Martin
      Pages 199-220

    4. Opioid System Involvement in Cannabinoid Tolerance and Dependence

      • Rafael Maldonado
      Pages 221-245

  5. Alcohol and Nicotine Addiction

    1. Front Matter

      Pages 247-247
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    2. Current Strategies for Identifying Genes for Alcohol Sensitivity

      • John C. Crabbe
      Pages 249-261

    3. Genetic Basis of Ethanol Reward

      • Christopher L. Cunningham, Tamara J. Phillips
      Pages 263-294

    4. Behavioral and Molecular Aspects of Alcohol Craving and Relapse

      • Rainer Spanagel
      Pages 295-313
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Keywords

About this book

A comprehensive multidisciplinary review of the most relevant molecular, genetic, and behavioral approaches used to investigate the neurobiological basis of drug addiction. The authors explore the latest findings on opioid, psychostimulant, cannabinoid, alcohol, and nicotine addiction, provide fresh insights into the genetic basis of drug addiction and the new therapeutic perspectives these have opened. They describe the technology available to generate conditional knockout mice and show how these mice can reveal the molecular basis of opioid, psychostimulant, and cannabinoid addiction. They also review the different behavioral models available to evaluate the rewarding effects of drugs and analyze the genes involved in alcohol dependence.

Reviews

"I found this text to be a wonderful compilation...each chapter highlighted the use of recently established techniques to provide an improved understanding of the role of specific membrane transport pathways, hormone receptors, intracellular signaling pathways and even circulating hormone and drug levels deep within the brain." -Pharmaceutical Research

Editors and Affiliations

  • Laboratory of Neuropharmacology Health and Life Sciences School, Universitat Pompeu Fabra, Barcelona, Spain

    Rafael Maldonado

Bibliographic Information

  • Book Title: Molecular Biology of Drug Addiction

  • Editors: Rafael Maldonado

  • DOI: https://doi.org/10.1007/978-1-59259-343-9

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2003

  • Hardcover ISBN: 978-1-58829-060-1Published: 12 September 2002

  • Softcover ISBN: 978-1-61737-330-5Published: 05 November 2010

  • eBook ISBN: 978-1-59259-343-9Published: 12 September 2002

  • Edition Number: 1

  • Number of Pages: X, 346

  • Number of Illustrations: 3 b/w illustrations

  • Topics: Neurosciences

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