Skip to main content
SpringerLink
Log in

Innate Immunity

  • Book
  • © 2003

Overview

Editors:
  1. R. Alan B. Ezekowitz

    1. Laboratory of Developmental Immunology, Massachusetts General Hospital, Boston, USA
      Department of Pediatrics, Harvard Medical School, Boston, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Jules A. Hoffmann

    1. Institute of Molecular and Cellular Biology, CNRS, Strasbourg, France

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Infectious Disease (ID)

  • 7917 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (21 chapters)

  1. Front Matter

    Pages i-xi
    Download chapter PDF

  2. Plant Immunity

    1. Front Matter

      Pages 1-2
      Download chapter PDF

    2. Pathogen Recognition and Signal Transduction in Plant Immunity

      • Jonathan Cohn, Gregory B. Martin
      Pages 3-26

    3. Plant Disease Resistance Genes

      • Jeffrey G. Ellis, David A. Jones
      Pages 27-45

    4. Nonhost Resistance in Plants to Microbial Pathogens

      • Michèle C. Heath
      Pages 47-57

  3. Invertebrate Host Defense Immunity

    1. Front Matter

      Pages 59-60
      Download chapter PDF

    2. Regulatory Co-options in the Evolution of Deuterostome Immune Systems

      • Ellen V. Rothenberg, Eric H. Davidson
      Pages 61-87

    3. Antimicrobial Peptides in Insect Immunity

      • Philippe Bulet, Maurice Charlet, Charles Hetru
      Pages 89-107

    4. Innate Immunity in the Horseshoe Crab

      • Shun-ichiro Kawabata, Tsukasa Osaki, Sadaaki Iwanaga
      Pages 109-125

    5. Pattern Recognition Receptors in Drosophila

      • Mika Rämet, Alan Pearson, Kati Baksa, Asha Harikrishnan
      Pages 127-135

    6. Humoral and Cellular Responses in Drosophila Innate Immunity

      • Julien Royet, Marie Meister, Dominique Ferrandon
      Pages 137-153

    7. Thioester-Containing Proteins of Protostomes

      • Elena A. Levashina, Stéphanie Blandin, Luis F. Moita, Marie Lagueux, Fotis C. Kafatos
      Pages 155-173

  4. Mammalian Host Defenses: Pattern Recognition Receptors

    1. Front Matter

      Pages 175-176
      Download chapter PDF

  5. Mammalian Host Defenses: Pattern Recognition Receptors

    1. Toll-Like Receptors

      • Tsuneyasu Kaisho, Shizuo Akira
      Pages 177-189

  6. Mammalian Host Defenses: Pattern Recognition Receptors

    1. The Macrophage Mannose Receptor and Innate Immunity

      • Thiruvamoor P. Ramkumar, Djilali Hammache, Philip D. Stahl
      Pages 191-204

    2. Diverse Roles of Lung Collectins in Pulmonary Innate Immunity

      • Erika C. Crouch, Jeffrey A. Whitsett
      Pages 205-229

    3. Structures of Complement Control Proteins

      • Thilo Stehle, Mykol Larvie
      Pages 231-253

    4. Lipopolysaccharide-Binding Protein and CD14

      • Peter S. Tobias
      Pages 255-265

  7. Mammalian Host Defenses: Links Between Innate and Adaptive Immunity

    1. Front Matter

      Pages 267-268
      Download chapter PDF

  8. Mammalian Host Defenses: Links Between Innate and Adaptive Immunity

    1. The Role of Chemokines in Linking Innate and Adaptive Immunity

      • Cory M. Hogaboam, Steven L. Kunkel
      Pages 269-286
Back to top

Keywords

About this book

The concept of innate immunity refers to the first-line host defense that serves to limit infection in the early hours after exposure to microorganisms. Recent data have highlighted similarities between pathogen recognition, signaling pathways, and effector mechanisms of innate immunity in Drosophila and mammals, pointing to a common ancestry of these defenses. In addition to its role in the early phase of defense, innate immunity in mammals appears to playa key role in stimulating the subsequent clonal response of adaptive immunity. Recent exciting information has determined that the templates that are laid down in primitive life forms, like flowering plants and insects, form the basic principles of first­ line host defense that are conserved in mammalian systems. The next frontier in the field is to understand the dynamic adaptive changes that occur as a result of the inter­ play between host defenses and infectious agents. One emerging theme is that microorganisms are constantly seeking ways to co-opt host defenses. On the other hand, host defense to infection is mediated by the coordinate action of pattern recognition molecules and receptors that, in mammals, are important and probably necessary antecedents to the development of an adaptive immune response. Innate Immunity aims to explore the intersection between host pathogen interactions across an evolutionary spectrum that will inform our understanding of the dynamic interplay between infectious agents and host defense in man.

Editors and Affiliations

  • Laboratory of Developmental Immunology, Massachusetts General Hospital, Boston, USA

    R. Alan B. Ezekowitz

  • Department of Pediatrics, Harvard Medical School, Boston, USA

    R. Alan B. Ezekowitz

  • Institute of Molecular and Cellular Biology, CNRS, Strasbourg, France

    Jules A. Hoffmann

Bibliographic Information

  • Book Title: Innate Immunity

  • Editors: R. Alan B. Ezekowitz, Jules A. Hoffmann

  • Series Title: Infectious Disease

  • DOI: https://doi.org/10.1007/978-1-59259-320-0

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2003

  • Hardcover ISBN: 978-1-58829-046-5Published: 06 December 2002

  • Softcover ISBN: 978-1-4684-9746-5Published: 08 August 2012

  • eBook ISBN: 978-1-59259-320-0Published: 06 December 2002

  • Edition Number: 1

  • Number of Pages: XI, 410

  • Number of Illustrations: 60 b/w illustrations

  • Topics: Immunology

Publish with us

Policies and ethics

Back to top

Search

Navigation