Oncogene-Directed Therapies

1. Front Matter

   Pages i-xiii

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2. Basic Concepts in Oncogene Research

   1. Front Matter

      Pages 1-1

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   2. Genetic Basis of Cancer Progression

      • Susan J. Done, Jeremy A. Squire

      Pages 3-17

   3. The Molecular Basis of Chromosomal Instability in Human Cancer Cells

      • Daniel P. Cahill

      Pages 19-33

   4. Signal Transduction Networks

      • Frank McCormick

      Pages 35-46

   5. Oncogenic Receptor Tyrosine Kinases

      • Mark H. Kirschbaum, Mina D. Marmor, Yosef Yarden

      Pages 47-75

   6. Ras-Mediated Deregulation of Gene Expression and Contribution to Oncogenesis

      • Gretchen A. Murphy, Channing J. Der

      Pages 77-99

   7. The Interplay Between Tumor Suppressor Genes and Oncogenes in Tumorigenesis

      • Eric C. Holland

      Pages 101-112

   8. Genetic Basis of Altered Responsiveness of Cancer Cells to Their Microenvironment

      • Amato J. Giaccia

      Pages 113-129

3. The Functional Impact of Oncogene Expression on Cancer Cells—Therapeutic Implications

   1. Front Matter

      Pages 131-131

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   2. Deregulation of Cell Cycle Progression by Oncogenic Transformation

      • Marcelo L. Rodriguez-Puebla, Adrian M. Senderowicz, Claudio J. Conti

      Pages 133-151

   3. Oncogenes as Regulators of Cell Survival

      • Kirill Rosen, Jorge Filmus

      Pages 153-169

   4. Oncogenes and Tumor Angiogenesis

      • Janusz Rak, Robert S. Kerbel

      Pages 171-218

   5. Oncogenes as Therapeutic Targets to Prevent Metastasis

      • Ann F. Chambers, Hemanth J. Varghese

      Pages 219-228

   6. The Impact of Oncogenes on Tumor Maintenance

      • Senji Shirasawa, Takehiko Sasazuki

      Pages 229-243

   7. Primary and Secondary Events in Oncogene-Driven Tumor Development

      • Michaela Herzig, Gerhard Christofori

      Pages 245-294

4. Oncogenes as Targets for Anticancer Therapy in Vivo

   1. Front Matter

      Pages 295-295

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   2. Targeting Oncogenes in Hematopoietic Malignancies

      • Michael E. O’Dwyer, Brian J. Druker

      Pages 297-311

   3. Clinical Evaluation of Agents Targeting Epidermal Growth Factor Receptor (EGFR) in Cancer

      • Edward H. Lin, James L. Abbruzzese

      Pages 313-330

   4. Inhibition of the HER-2/neu Oncogene

      • Gottfried E. Konecny, Jane Arboleda, Dennis J. Slamon, Mark Pegram

      Pages 331-351

Prominent investigators and clinicians summarize in a balanced blend of fundamental science, basic research, experimental therapeutics, and early clinical experiences, what is known about oncogenes and oncogenesis, and describe how that knowledge can be used to treat the cancer. The contributors explain how, why, and under what conditions certain proteins acquire the ability to transform eukaryotic cells, and detail the crucial biological consequences of this oncogenic transformation, particularly for cellular mitogenesis, survival, differentiation, migration, proteolysis, or angiogenic competence. Their articles thoroughly explicate the premises, principles, techniques, and approaches to oncogene targeting in various types of human cancer by using signal transduction inhibitors, immunological targeting methods, and antisense gene therapy.

• angiogenesis
• cell
• gene therapy
• metastasis
• oncogene
• tumor
• tumorigenesis

"The book is well referenced, and readers will easily be able to locate primary literature for in-depth reading on specific topics. The figures and illustrations are extremely useful in summarizing complex topics that are discussed. In summary, this is an unique, well-organized, and timely presentation on a topic of high importance. People who will find this volume especially useful include students of tumor biology, basic scientists with an interest in novel therapeutic or translational research, and all clinicians who are involved in the diagnosis and treatment of patients with cancer." - Neuro-oncology

"This book attempts to cover a vast and rapidly evolving field of research, both basic and clinical, and does so successfully by giving the reader a balanced mix of basic science, experimental therapeutics and clinical observations. Most chapters are richly illustrated and all have extensive lists of relevant references." - Medical Oncology

"...this book will be useful not only to those just starting their research careers, including graduate and medical students, but also to those who have been involved in the field of cancer biology and treatment for a number of years, including seasoned scientists and clinicians." -Doody's Health Sciences Book Review Journal

• Henderson Research Centre, Department of Medicine, McMaster University, Hamilton, Canada

  Janusz Rak

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