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Treatment of Acute Leukemias

New Directions for Clinical Research

  • Book
  • © 2003

Overview

Editors:
  1. Ching-Hon Pui

    1. St. Jude Children’s Research Hospital, University of Tennessee Health Science Center, Memphis, USA

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Part of the book series: Current Clinical Oncology (CCO)

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Table of contents (42 chapters)

  1. Front Matter

    Pages I-XV
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  2. Diagnosis, Classification, and Prognosis

    1. Front Matter

      Pages 1-1
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    2. Classification of Acute Leukemias

      • Wolf-Dieter Ludwig, Torsten Haferlach, Claudia Schoch
      Pages 3-41

    3. Classification of Acute Leukemias

      • Frederick G. Behm
      Pages 43-58

  3. Chemotherapeutic Strategies

    1. Front Matter

      Pages 59-59
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    2. Infant Leukemias

      1. Biology and Treatment of Infant Leukemias
        • Rob Pieters
        Pages 61-73
      2. Biology and Treatment of Acute Leukemias in Infants
        • Gregory H. Reaman
        Pages 75-83

    3. Childhood Acute Lymphoblastic Leukemia

      1. Treatment of Childhood Acute Lymphoblastic Leukemia
        • Martin Schrappe, Martin Stanulla
        Pages 87-104
      2. Treatment of Childhood Acute Lymphoblastic Leukemia
        • Lewis B. Silverman, Stephen E. Sallan
        Pages 105-110

    4. Acute Lymphoblastic Leukemia in Adolescents and Young Adults

      1. Treatment of Acute Lymphoblastic Leukemia in Adolescents and Young Adults
        • Sima Jeha, Hagop Kantarjian
        Pages 113-120
      2. Treatment of Adolescents and Young Adults with Acute Lymphoblastic Leukemia
        • James Nachman
        Pages 121-128

    5. Acute Lymphoblastic Leukemia in Adults

      1. Treatment of Adult Acute Lymphoblastic Leukemia
        • Spero R. Cataland, Richard A. Larson
        Pages 131-141
      2. Treatment of Adult Acute Lymphoblastic Leukemia
        • Dieter Hoelzer, Nicola Gökbuget
        Pages 143-157

    6. Central Nervous System Therapy for Acute Lymphoblastic Leukemia

      1. Central Nervous System-Directed Therapy for Acute Lymphoblastic Leukemia
        • Judith M. Chessells
        Pages 161-172
      2. Diagnosis, Prophylaxis, and Treatment of Central Nervous System Involvement in Acute Lymphoblastic Leukemia
        • Anjo J. P. Veerman
        Pages 173-180

    7. Relapsed Acute Lymphoblastic Leukemia

      1. Treatment of Relapsed Acute Lymphoblastic Leukemia
        • Helmut Gadner, Georg Mann, Christina Peters
        Pages 183-197
      2. Treatment of Relapsed Acute Lymphoblastic Leukemia
        • Günter Henze, Arend Von Stackelberg
        Pages 199-219

    8. B-Cell Acute Lymphoblastic Leukemia

      1. Treatment of B-Cell Acute Lymphoblastic Leukemia
        • Catherine Patte
        Pages 223-228
      2. Treatment of B-Cell Acute Lymphoblastic Leukemia
        • John T. Sandlund
        Pages 229-234

    9. Acute Myeloid Leukemia in Children

      1. Treatment of Acute Myeloid Leukemia in Children
        • Ursula Creutzig
        Pages 237-253
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Keywords

About this book

Although much progress has been made in the treatment of acute leukemia, there is still vigorous debate over the optimal methods for securing additional gains in event-free survival and for reducing the toxic side effects of "curative" therapy. In Treatment of Acute Leukemias: New Directions for Clinical Research, international experts not only review the state-of-the-art in managing children and adults with acute leukemia, but also debate the pros and cons of current controversial and problematic issues. The book summarizes the best diagnostic and treatment practices for newly diagnosed and relapsed acute lymphoblastic and myeloid leukemia in children, adolescents, and adults. Among the therapies considered are methotrexate, asparaginase, antipurines, epipodophyllotoxins, hematopoietic stem cell transplantation, hematopoietic growth factors, and immunotherapy. Problems of central-nervous-system therapy, minimal residual disease, drug resistance, and directions of future research are also considered. Discussion of each major topic by two distinguished groups of investigators ensures broad and balanced coverage.
Comprehensive and up-to-date, Treatment of Acute Leukemias: New Directions for Clinical Research offers oncologists practical guidelines for precise diagnosis and optimal treatment of childhood and adult acute leukemia, as well as insights into those aspects of patient management most in need of further study and refinement.

Reviews

"...This book offers the best approach to the presentation of problems related to the treatment of the acute leukemias that I know of. The idea of having different groups of investigators give their views on the topics and the emphasis on future directions make it an important contribution to the study of leukemia. Treatment of Acute Leukemias should be read by both adult and pediatric hematologists and oncologists, and it should be required reading for trainees in these disciplines. Dr. Pui, who has already made major contributions through his own work, has added greatly to the future of the field by organizing and editing this impressive book." -New England Journal of Medicine

"...comprehensive and up to date. This is one of the best books produced in recent years on the diagnosis and management of the acute leukaemias." - European Journal of Haematology

Editors and Affiliations

  • St. Jude Children’s Research Hospital, University of Tennessee Health Science Center, Memphis, USA

    Ching-Hon Pui

Bibliographic Information

  • Book Title: Treatment of Acute Leukemias

  • Book Subtitle: New Directions for Clinical Research

  • Editors: Ching-Hon Pui

  • Series Title: Current Clinical Oncology

  • DOI: https://doi.org/10.1007/978-1-59259-307-1

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2003

  • Hardcover ISBN: 978-0-89603-834-9Published: 14 November 2002

  • Softcover ISBN: 978-1-61737-212-4Published: 19 November 2010

  • eBook ISBN: 978-1-59259-307-1Published: 14 November 2002

  • Series ISSN: 2364-1134

  • Series E-ISSN: 2364-1142

  • Edition Number: 1

  • Number of Pages: XVI, 562

  • Topics: Hematology

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