Microbial DNA and Host Immunity

1. Front Matter

   Pages i-xvii

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2. Introduction

   1. Front Matter

      Pages 1-1

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   2. Immunostimulatory DNA

      • Eyal Raz

      Pages 3-8

   3. 2 Historical Perspectives

      • Saburo Yamamoto, Toshiko Yamamoto, Tohru Tokunaga

      Pages 9-14

3. Receptors and Signaling

   1. Front Matter

      Pages 15-15

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   2. Signal Transduction Pathways Activated By CpG-DNA

      • Hans Häcker

      Pages 17-38

   3. A Novel Toll-Like Receptor that Recognizes Bacterial DNA

      • Hiroaki Hemmi, Shizuo Akira

      Pages 39-47

   4. 5 Activation of Innate Immunity by Microbial Nucleic Acids

      • Wen-Ming Chu, Xing Gong, Tony Yoon

      Pages 49-61

   5. Phosphorothioate Backbone Modification Changes the Pattern of Responses to CpG

      • Katryn J. Stacey, David P. Sester, Shalin Naik, Tara L. Roberts, Matthew J. Sweet, David A. Hume

      Pages 63-77

4. Cell Activation

   1. Front Matter

      Pages 79-79

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   2. Activation of NK Cell By Immunostimulatory Oligo-DNA in Mouse and Human

      • Saburo Yamamoto, Toshiko Yamamoto, Tetsuro Kataoka, Sumiko Iho, Tohru Tokunaga

      Pages 81-89

   3. Regulation of Antigen Presenting Cell Function by CpG DNA

      • David Askew, Rose S. Chu, Clifford V. Harding

      Pages 91-101

   4. Activation of B cells by CpG Motifs in Bacterial DNA

      • Ae-Kyung Yi, Arthur M. Krieg

      Pages 103-127

   5. IFN-Dependent Pathways for Stimulation of Memory CD8+ Cells

      • Jonathan Sprent

      Pages 129-135

   6. Cross-Priming of CD8+ T Cells by Immunostimulatory Sequence DNA

      • Hearn Jay Cho, Sandip Datta, Eyal Raz

      Pages 137-149

5. Vaccination Strategies

   1. Front Matter

      Pages 151-151

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   2. The Th1 Adjuvant Effect of Immunostimulatory (ISS) DNA Sequences

      • Maripat Corr, Chih Min Tang

      Pages 153-162

   3. Immunostimulatory DNA Prepriming for the Induction of Th1 and Prevention of Th2 Biased Immune Responses

      • Hiroko Kobayashi, Elena Martin-Orozco, Kenji Takabayashi, Anthony A. Horner

      Pages 163-174

   4. Protein-Immunostimulatory DNA-Conjugate

      • Kenji Takabayashi, Helen Tighe, Lucinda Beck, Hans L. Spiegelberg

      Pages 175-188

   5. Immunostimulatory DNA Sequence Based Mucosal Vaccines

      • Anthony A. Horner

      Pages 189-202

Leading researchers review the activation of the mammalian immune system by bacterial DNA and its immunostimulatory sequences (ISS), and consider the applications of ISS in clinical medicine. The authors survey the latest findings concerning the receptor-recognition and signaling pathways triggered by ISS , the process of cell activation, and the potential vaccination strategies using ISS. Specific pharmaceutical applications discussed include infectious disease (Hepatitis B, HIV, and mycobacterial infections), allergy (asthma and conjunctivitis), cancer (lymphoma), and inflammation and autoimmunity (arthritis and colitis).

• Antigen
• Asthma
• DNA
• HIV
• Nucleotide
• infections
• infectious disease

"I am delighted, therefore to have found this book, which thoroughly reviews the field by contributions from most of the key names associated with the subject. For those not yet initiated into the tell-tale nature of ISS-DNA presented by non-self, the excellent introductory chapter by Eyal Raz(Editor) will reveal all you need to know to read the rest of the book. It summarizes the role of Toll Receptors(TLR) as sensors of infection by recognition of conserved molecular patterns in pathogenic bacteria (PAMPS), a subject very topical these days but riddled with a lot of new reference terms for the poor immunologist to contend with. This new book highlights the fact that even the ubiquitous DNA molecule has been the subject of critical censorship during evolution and has allowed the mammalian innate immune response to use subtle differences between prokaryotic and eukaryotic DNA to inform of bacterial invasion...recommended as an excellent library acquisition, if not a departmental one." -- Immunology News

"This is a worthwhile endeavor and the book is of value. Investigators interested in the overall utility of these DNA sequences will find useful material..." -Doody's Health Sciences Book Review Journal

• University of California, San Diego, La Jolla, USA

  Eyal Raz

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