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Neuroinflammation

Mechanisms and Management

  • Book
  • © 2003

Overview

Editors:
  1. Paul L. Wood

    1. Oxon Medica, South San Francisco, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Contemporary Neuroscience (CNEURO)

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Table of contents (22 chapters)

  1. Front Matter

    Pages i-xi
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  2. Neuroinflammatory Mechanisms

    1. Front Matter

      Pages 1-1
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    2. Microglia

      • Paul L. Wood
      Pages 3-27

    3. Apoptosis vs Nonapoptotic Mechanisms in Neurodegeneration

      • Kurt A. Jellinger
      Pages 29-88

    4. Role(s) of Mitogen and Stress-Activated Kinases in Neurodegeneration

      • Christopher C. J. Miller, Steven Ackerley, Janet Brownlees, Andrew J. Grierson, Paul Thornhill
      Pages 89-97

    5. Roles of Chemokines and Their Receptors in Neuroinflammation

      • Andrzej R. Glabinski, Richard M. Ransohoff
      Pages 99-115

    6. Neurotoxic Mechanisms of Nitric Oxide

      • Kathleen M. K. Boje
      Pages 117-135

    7. Chronic Intracerebral LPS as a Model of Neuroinflammation

      • Gary L. Wenk, Beatrice Hauss-Wegrzyniak
      Pages 137-150

    8. Peroxisome Proliferator-Activated Receptor Gamma Agonists

      • Gary E. Landreth, Sophia Sundararajan, Michael T. Heneka
      Pages 151-169

    9. Neuroinflammation-Mediated Neurotoxin Production in Neurodegenerative Diseases

      • Robert A. Floyd, Kenneth Hensley
      Pages 171-186

  3. Stroke and TBI

    1. Front Matter

      Pages 187-187
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    2. Inflammation and Potential Anti-Inflammatory Approaches in Stroke

      • Jari Koistinaho, Juha Yrjänheikki
      Pages 189-213

    3. Neuroinflammation as an Important Pathogenic Mechanism in Spinal Cord Injury

      • Yuji Taoka, Kenji Okajima
      Pages 215-235

    4. Type IV Collagenases and Blood-Brain Barrier Breakdown in Brain Ischemia

      • Yvan Gasche, Jean-Christophe Copin, Pak H. Chan
      Pages 237-245

  4. Alzheimer’s Disease

    1. Front Matter

      Pages 247-247
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    2. Neuroinflammatory Environments Promote Amyloid-ß Deposition and Posttranslational Modification

      • Craig S. Atwood, Mark A. Smith, Ralph N. Martins, Rudolph E. Tanzi, Alex E. Roher, Ashley I. Bush et al.
      Pages 249-266

    3. Microglial Responses in Alzheimer’s Disease

      • Douglas G. Walker, Lih-Fen Lue
      Pages 267-282

    4. The Amyloid Hypothesis of Cognitive Dysfunction

      • Dave Morgan, Marcia N. Gordon
      Pages 283-293

    5. The Cerebellum in AD

      • Paul L. Wood
      Pages 295-300

    6. The Neuroinflammatory Components of the Trimethyltin (TMT) Model of Hippocampal Neurodegeneration

      • G. Jean Harry, Christian Lefebvre d’Hellencourt
      Pages 301-329
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Keywords

About this book

In this thoroughly updated and revised edition of his much praised book, Paul L. Wood and a panel of leading researchers capture these new developments in a masterful synthesis of what is known today about the inflammatory mediators and cells involved in neurodegenerative diseases. This second edition contains extensive updates on the mediators produced by microglia and their role in neuroinflammatory-induced neuronal lysis. There is also increased coverage of the animal models used in the study of neuroinflammatory mechanisms, of the new imaging methods that allow the noninvasive evaluation of microglial activation in human neurodegernerative disorders, and of the role of neuroinflammation in amyloid-dependent neuronal lysis.

Reviews

Review of the first edition:
"...will reach a wide audience including basic and clinical neuroscientists. . .fills a significant gap in the literature...provides an excellent starting point, and offers insight into the rapid pace of discovery within a field which influences most aspects of nervous system function."-Nature Medicine

"...fills a significant gap in the literature...provides an excellent starting point..."
-Nature Medicine

"...will be useful to a wide variety of researchers and clinicians, particularly [those] interested in neurodegenerative disorders ..."
-Neurological Research

"...provides a thorough overview of cells and mechanisms of brain inflammation, their role in disease and future therapeutic avenues to overcome it."
-Microbiology Today

"...a timely addition that will aid our understanding today."
-Receptors & Signal Transduction

Editors and Affiliations

  • Oxon Medica, South San Francisco, USA

    Paul L. Wood

Bibliographic Information

  • Book Title: Neuroinflammation

  • Book Subtitle: Mechanisms and Management

  • Editors: Paul L. Wood

  • Series Title: Contemporary Neuroscience

  • DOI: https://doi.org/10.1007/978-1-59259-297-5

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2003

  • Hardcover ISBN: 978-1-58829-002-1Published: 18 December 2002

  • Softcover ISBN: 978-1-4684-9720-5Published: 24 July 2012

  • eBook ISBN: 978-1-59259-297-5Published: 18 December 2002

  • Edition Number: 2

  • Number of Pages: XII, 420

  • Number of Illustrations: 48 b/w illustrations, 5 illustrations in colour

  • Topics: Neurosciences

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