Overview
- Editors:
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Lisa Bellavance English
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BD Biosciences, San Jose
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Table of contents (21 protocols)
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Library Synthesis and Quality Control
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- Fahad Al-Obeidi, John F. Okonya, Richard E. Austin, Dan R. S. Bond
Pages 3-14
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- Jean-Louis Aubagnac, Robert Combarieu, Christine Enjalbal, Jean Martinez
Pages 15-22
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- Viktor Krchňák, Andrew Burritt
Pages 41-59
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- Peter O. Krutzik, A. Richard Chamberlin
Pages 77-92
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- Amy Lew, A. Richard Chamberlin
Pages 93-109
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- Gérard Rossé, Peter Neidig, Harald Schröder
Pages 123-139
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- Paul Wentworth Jr., Carsten Spanka
Pages 167-187
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- Bing Yan, Liling Fang, Mark M. Irving, Jiang Zhao, Diana Liu, Gianine M. Figliozzi et al.
Pages 189-200
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Library Purification and Screening
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Front Matter
Pages 201-201
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- Tingyu Li, Yan Wang, Louis H. Bluhm
Pages 203-213
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- Seema Choudhary, Janet R. Morrow
Pages 215-225
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- Sean X. Peng, Charles Henson
Pages 227-237
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- David S. Thorpe, Gérard Rossé, Helen Yeoman, Sydney Wilson, Patti Willson, Greg Harlow et al.
Pages 239-263
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Computational Library Design
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Front Matter
Pages 265-265
About this book
The continued successes of large- and small-scale genome sequencing projects are increasing the number of genomic targets available for drug d- covery at an exponential rate. In addition, a better understanding of molecular mechanisms—such as apoptosis, signal transduction, telomere control of ch- mosomes, cytoskeletal development, modulation of stress-related proteins, and cell surface display of antigens by the major histocompatibility complex m- ecules—has improved the probability of identifying the most promising genomic targets to counteract disease. As a result, developing and optimizing lead candidates for these targets and rapidly moving them into clinical trials is now a critical juncture in pharmaceutical research. Recent advances in com- natorial library synthesis, purification, and analysis techniques are not only increasing the numbers of compounds that can be tested against each specific genomic target, but are also speeding and improving the overall processes of lead discovery and optimization. There are two main approaches to combinatorial library production: p- allel chemical synthesis and split-and-mix chemical synthesis. These approaches can utilize solid- or solution-based synthetic methods, alone or in combination, although the majority of combinatorial library synthesis is still done on solid support. In a parallel synthesis, all the products are assembled separately in their own reaction vessels or microtiter plates. The array of rows and columns enables researchers to organize the building blocks to be c- bined, and provides an easy way to identify compounds in a particular well.
Reviews
"...an excellent work that covers many important aspects, gives easy access to literature for further study, and contains much practical advice. As it describes many different tools and techniques it is especially suitable for beginners in combinatorial chemistry, and deserves to be added to the list of well presented works in this field." - Angewandte Chemie
"The book provides a wealth of excellent reference material and it is a worthwhile addition to the library of most medicinal chemists." -Journal of Medicinal Chemistry
Editors and Affiliations
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BD Biosciences, San Jose
Lisa Bellavance English
