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Tumor Suppressor Genes in Human Cancer

  • Book
  • © 2001

Overview

Editors:
  1. David E. Fisher

    1. Dana Farber Cancer Institute, Harvard Medical School, Boston, USA

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Part of the book series: Cancer Drug Discovery and Development (CDD&D)

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-xii
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  2. Analysis and Clinical Implications of Tumor Suppressor Genes

    1. Front Matter

      Pages 1-1
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    2. Animal Models for Tumor Suppressor Genes

      • Jordan A. Kreidberg, Thomas A. Natoli
      Pages 3-28

    3. Viral Oncoproteins as Probes for Tumor Suppressor Function

      • Srikumar P. Chellappan
      Pages 29-48

    4. Tumor Suppressors in Metastasis

      • Taoufik Ouatas, Melanie T. Hartsough, Patricia S. Steeg
      Pages 49-77

    5. Apoptosis

      • Jinyan Du, David E. Fisher
      Pages 79-101

    6. Drug Discovery in Oncology

      • Alex Matter
      Pages 103-128

  3. Tumor Suppressor Pathways

    1. Front Matter

      Pages 129-129
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    2. Retinoblastoma Protein in Growth Control and Differentiation

      • Lilia Stepanova, J. Wade Harper
      Pages 131-157

    3. p53 Tumor Suppressor Protein

      • Margaret Ashcroft, Karen H. Vousden
      Pages 159-181

    4. p16 Tumor Suppressor

      • Alexander Kamb, Ken McCormack
      Pages 183-195

    5. DNA Mismatch Repair in Tumor Suppression

      • Guo-Min Li, Scott McCulloch, Liya Gu
      Pages 197-229

    6. PTEN

      • Jen Jen Yeh, William R. Sellers
      Pages 231-251

    7. Neurofibromatoses

      • André Bernards, Andrea I. McClatchey
      Pages 253-280

    8. Von Hippel-Lindau Disease

      • Othon Iliopoulos, William G. Kaelin Jr.
      Pages 281-305

    9. Wilms’ Tumor

      • Aswin L. Menke, Nick D. Hastie
      Pages 307-350

    10. Fanconi Anemia Pathway and Cancer Susceptibility

      • Yanan Kuang, Irene Garcia-Higuera, Eric Nisbet-Brown, Anna Savoia, Alan D. D’Andrea
      Pages 351-373

  4. Back Matter

    Pages 375-386
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Keywords

About this book

David Fisher, MD, PhD, and an authoritative panel of academic, cutting-edge researchers review and summarize the current state of the field. Describing the broad roles of tumor suppressors from a perspective based in molecular biology and genetics, the authors detail the major suppressors and the pathways they regulate, including cell cycle progression, stress responses, apoptosis, and responses to DNA damage. Leading-edge and forward-looking, Tumor Suppressor Genes in Human Cancer illuminates what is currently known of tumor suppressor genes and their regulation, work that is already beginning to revolutionize cancer target elucidation, drug discovery, and treatment design.

Reviews

"...brings together a panel of experts in the field of cancer biology, with almost half of the authors from Harvard Medical School. ...describes he role of tumor suppressor genes in human cancer. It details a current view of these important genes and highlights clinically relevant aspects of the strides made in the field of tumor suppressor biology. ...The book is well organized with most chapters having figures and tables to clarify the points made in the text. It is well referenced....This book provides readable, yet thorough, coverage of the field of tumor suppressor biology." -Doody's Health Sciences Book Review Journal

Editors and Affiliations

  • Dana Farber Cancer Institute, Harvard Medical School, Boston, USA

    David E. Fisher

Bibliographic Information

  • Book Title: Tumor Suppressor Genes in Human Cancer

  • Editors: David E. Fisher

  • Series Title: Cancer Drug Discovery and Development

  • DOI: https://doi.org/10.1007/978-1-59259-230-2

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: Humana Press 2001

  • Hardcover ISBN: 978-0-89603-807-3Published: 26 October 2000

  • Softcover ISBN: 978-1-61737-198-1Published: 19 November 2010

  • eBook ISBN: 978-1-59259-230-2Published: 26 October 2000

  • Series ISSN: 2196-9906

  • Series E-ISSN: 2196-9914

  • Edition Number: 1

  • Number of Pages: XII, 386

  • Topics: Oncology

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