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Renal Cell Carcinoma

Molecular Biology, Immunology, and Clinical Management

  • Book
  • © 2000

Overview

Editors:
  1. Ronald M. Bukowski

    1. Experimental Therapeutics, Cleveland Clinic Taussig Cancer Center, Cleveland, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Andrew C. Novick

    1. Department of Urology, Cleveland Clinic Foundation, Cleveland, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Current Clinical Oncology (CCO)

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Table of contents (26 chapters)

  1. Front Matter

    Pages i-xi
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  2. Introduction

    1. Front Matter

      Pages 1-1
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    2. The Epidemiology of Renal Cell Carcinoma

      • Joshua E. Muscat
      Pages 3-13

    3. The Pathology of Renal Neoplasms

      • Howard S. Levin, Jonathan L. Myles
      Pages 15-38

    4. Immunologic Response to Renal Cell Carcinoma

      • James H. Finke, Lisa Salvucci Kierstead, Elena Ranieri, Walter J. Storkus
      Pages 39-62

    5. Molecular Mechanisms of Immune Dysfunction in Renal Cell Carcinoma

      • Robert G. Uzzo, Patricia Rayman, Andrew C. Novick, Ronald M. Bukowski, James H. Finke
      Pages 63-78

    6. Molecular Genetics of Renal Cell Carcinoma

      • Erik Enquist, Norman Zambrano, Burton Zbar, W. Marston Linehan, McClellan M. Walther
      Pages 79-92

    7. Screening for Renal Cell Carcinoma

      • Evan B. Cohn, Steven C. Campbell
      Pages 93-110

    8. Renal Cell Carcinoma

      • Joel W. Slaton, David A. Swanson
      Pages 111-134

    9. Paraneoplastic Syndromes in Renal Cell Carcinoma

      • Riyadh Aldaabil, David Peereboom
      Pages 135-145

    10. Prognostic Factors in Metastatic Renal Cell Carcinoma

      • Paul J. Elson
      Pages 147-160

  3. Management of Localized Renal Cell Carcinoma

    1. Front Matter

      Pages 161-161
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    2. Radical Nephrectomy and Nephron-Sparing Surgery for Localized Renal Cell Carcinoma

      • Andrew C. Novick
      Pages 163-172

    3. Management of Patients with Renal Cell Carcinoma and Vena Caval Thrombi

      • Chad W. M. Ritenour, Fray F. Marshall
      Pages 173-187

    4. Laparoscopic Surgery for Renal Cell Carcinoma

      • Inderbir S. Gill
      Pages 189-202

    5. Adjuvant Therapy of Renal Cell Carcinoma

      • Ronald M. Bukowski
      Pages 203-212

  4. Management of Advanced and/or Metastatic Renal Cell Carcinoma

    1. Front Matter

      Pages 213-213
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    2. The Role of Nephrectomy and Metastasectomy for Advanced Renal Cell Carcinoma

      • Robert G. Uzzo, Andrew C. Novick
      Pages 215-228

    3. Management of Pulmonary Metastases in Renal Cell Carcinoma Patients

      • Thomas W. Rice
      Pages 229-238

    4. Management of Skeletal Metastases in Renal Cell Carcinoma Patients

      • Michael J. Joyce
      Pages 239-267
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Keywords

About this book

Renal cell carcinoma represents a heterogeneous group of tumors, the most common of which is clear cell adenocarcinoma. The annual incidence of this tumor appears to be rising and approximately 12,000 individuals die from this cancer annually in the United States. One third of patients who present have metastatic disease at the time of diagnosis, and another 40% who undergo nephrectomy will ultimately develop this complication. Over the past 10 years, a significant amount of new information concerning the epidemiology, mole- lar and immunologic characteristics, and therapy for patients with these tumors has appeared. The recognition that inherited forms of renal cancer exist, and that chromosomal abn- malities can be identified in these tumors, suggested a genetic basis for renal cell carcinoma. The familial cancer syndrome, Von Hippel Lindau disease, provided the setting in which the genetic abnormalites associated with the development of renal cancer were first described. Abnormalities of the VHL gene have also been detected in sporadic clear cell carcinoma, and it has now been recognized that approximately 80 % of these tumors will demonstrate ch- acteristic alterations. Currently the functions of the VHL protein are being investigated, and the biology of clear cell carcinoma of the kidney is under study. Additionally, papillary carcinomas of the kidney appear to express different molecular defects, and these are now being unraveled.

Reviews

"Every aspect of renal cell carcinoma, from basic science to advanced clinical management, is comprehensively covered. . .I firmly believe this is the most complete yet concise "monogram" on the subject of renal cancers. It is a high quality book that would be extremely useful for anyone who manages renal cell carcinomas on a regular basis. The basic science chapters and in particular the chapters on advanced/metastatic renal tumors are extremely well written and informative. This book is the only one of its kind and hence cannot be compared."-Weighted Numerical Score: 95 - 4 Stars!-Doody's Health Science Book Review Journal

"...a concise, well-organized book that discusses nearly every aspect of renal cancer, from epidemiology and pathology to the management of specific clinical situations and recent research in immunotherapy...This book has many strengths. One is its organization. Each chapter is divided into clearly labeled, short subsections, making it highly readable and allowing the reader to locate information on a particular topic efficiently. A second strength is its emphasis on the immunologic features of renal cancer...This excellent book is both useful and readable. Because of its wide scope but concise organization, it will be valuable to nearly everyone interested in renal cancer, including surgical and medical oncologists, clinical investigators, and laboratory investigators."-The New England Journal of Medicine

" The book is clearly written, the illustrations are informative and the references are complete. It's strongest point is the extensive attention paid to the immunologic aspects of RCC."-Annals of Oncology

Editors and Affiliations

  • Experimental Therapeutics, Cleveland Clinic Taussig Cancer Center, Cleveland, USA

    Ronald M. Bukowski

  • Department of Urology, Cleveland Clinic Foundation, Cleveland, USA

    Andrew C. Novick

Bibliographic Information

  • Book Title: Renal Cell Carcinoma

  • Book Subtitle: Molecular Biology, Immunology, and Clinical Management

  • Editors: Ronald M. Bukowski, Andrew C. Novick

  • Series Title: Current Clinical Oncology

  • DOI: https://doi.org/10.1007/978-1-59259-229-6

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2000

  • eBook ISBN: 978-1-59259-229-6Published: 10 April 2000

  • Series ISSN: 2364-1134

  • Series E-ISSN: 2364-1142

  • Edition Number: 1

  • Number of Pages: XI, 434

  • Number of Illustrations: 148 b/w illustrations

  • Topics: Oncology

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