Access this book
Tax calculation will be finalised at checkout
Other ways to access
Table of contents (17 chapters)
-
Front Matter
-
Diseased Regulatory Pathways
-
Front Matter
-
-
Future Directions
-
Front Matter
-
Keywords
About this book
At the midpoint of the 20th century, our knowledge of cancer was based on epide- ology and pathology, and treatment consisted of surgery and radiation therapy. At mid-century, Medawar and colleagues initiated the understanding of transplantation immunology, Farber described the first use of an antifolic drug to treat leukemia, and Jacobson and coworkers described the irradiation-protection effect of spleen cells. These observations opened the door to the development of chemotherapy and tra- plantation in the treatment of cancer. Despite the rapid development of these new disciplines, progress was usually based on empiric observations and clinical trials. The rapid advances in molecular biology at the end of the 20th century mark a new era in our knowledge of cancer. Molecular immunology, molecular genetics, mole- lar pharmacology, and the Human Genome Project are in the process of providing a level of understanding of cancer undreamed of in the past. Optimism is based on the firm belief that understanding at the molecular level will lead to better and earlier di- nosis, to new forms of treatment, and, most importantly, eventually to prevention of many types of cancer.
Reviews
"All the aspects of this complex and rapidly moving field are covered in this excellent book. Clinical oncologists will find a series of balanced reviews of the current state-of-the-art of the diagnosis and treatment of cancer based on molecular technology, and since cancer touches almost every field of clinical practice, specialists in other disciplines will find a very lucid and readable account of what is happening in one of the genuine success stories of molecular medicine."
From the foreword by Sir David Weatherall, FRS, Institute of Molecular Medicine, Oxford University, UK
"Principles of Molecular Oncology provides a bold new look at the evolution of our knowledge of cancer. Authors from many disciplines are bringing together the facets that provide a comprehensive view of the whole...The reader will enjoy the opportunity to pause and look at the whole field as it stands today. The book will be both informative and intellectually stimulating."
From the foreword by E. Donnall Thomas, MD, Fred Hutchinson Cancer Research Center and Nobel Laureate in Medicine/Physiology, 1990
"Practicing physicians and advanced medical students as well as biochemists, molecular biologiests, and geneticists involved in the identification of molecular markers, therapeutic targets, and the underlying basis of cancer will all benefit from the addition of Principles of molecular oncology to their bookshelves."--The Lancet
"...an excellent book devoted to exponentially evolving molecular oncology. The book under review covers the most important recent developments in the field of molecular oncology of human tumors in the way that can be understandable not only to clinical oncologists working in the field, but also to researchers of other fields as well." -Neoplasma
"'Principles of Molecular Oncology' gives an up-to-date and comprehensive account of the revolution in molecular biology over the last few decades and its relevance to laboratory and clinical oncology....The book is clearly set out, with largely well conceived and descriptive illustrations....the scope and detail of scientific data provided means that even those well grounded in molecular biology will find much of novel value. ...The major strength of this book lies in the ultimate section on future therapies....In summary, this book is a detailed informative summary of current knowledge of molecular oncology, with relevance both to the general oncologist and those interested in basic molecular research." - Annals of Oncology
"...is a useful text for both new and experienced investigators in cancer genetics. It provides a framework for learning how to evaluate the diagnostic, prognostic, and predictive value of the myriad new cancer-genetic alterations that will result from the HGP."-The American Society of Human Genetics
"...presents a rather comprehensive 'state-of-the-art' of progress made during the past two decades in understanding the molecular bases of cancer." - Biochimie
From the foreword by Sir David Weatherall, FRS, Institute of Molecular Medicine, Oxford University, UK
"Principles of Molecular Oncology provides a bold new look at the evolution of our knowledge of cancer. Authors from many disciplines are bringing together the facets that provide a comprehensive view of the whole...The reader will enjoy the opportunity to pause and look at the whole field as it stands today. The book will be both informative and intellectually stimulating."
From the foreword by E. Donnall Thomas, MD, Fred Hutchinson Cancer Research Center and Nobel Laureate in Medicine/Physiology, 1990
"Practicing physicians and advanced medical students as well as biochemists, molecular biologiests, and geneticists involved in the identification of molecular markers, therapeutic targets, and the underlying basis of cancer will all benefit from the addition of Principles of molecular oncology to their bookshelves."--The Lancet
"...an excellent book devoted to exponentially evolving molecular oncology. The book under review covers the most important recent developments in the field of molecular oncology of human tumors in the way that can be understandable not only to clinical oncologists working in the field, but also to researchers of other fields as well." -Neoplasma
"'Principles of Molecular Oncology' gives an up-to-date and comprehensive account of the revolution in molecular biology over the last few decades and its relevance to laboratory and clinical oncology....The book is clearly set out, with largely well conceived and descriptive illustrations....the scope and detail of scientific data provided means that even those well grounded in molecular biology will find much of novel value. ...The major strength of this book lies in the ultimate section on future therapies....In summary, this book is a detailed informative summary of current knowledge of molecular oncology, with relevance both to the general oncologist and those interested in basic molecular research." - Annals of Oncology
"...is a useful text for both new and experienced investigators in cancer genetics. It provides a framework for learning how to evaluate the diagnostic, prognostic, and predictive value of the myriad new cancer-genetic alterations that will result from the HGP."-The American Society of Human Genetics
"...presents a rather comprehensive 'state-of-the-art' of progress made during the past two decades in understanding the molecular bases of cancer." - Biochimie
Editors and Affiliations
Bibliographic Information
Book Title: Principles of Molecular Oncology
Editors: Miguel H. Bronchud, Mary Ann Foote, William P. Peters, Murray O. Robinson
DOI: https://doi.org/10.1007/978-1-59259-222-7
Publisher: Humana Totowa, NJ
-
eBook Packages: Springer Book Archive
Copyright Information: Springer Science+Business Media New York 2000
eBook ISBN: 978-1-59259-222-7Published: 14 February 2000
Edition Number: 1
Number of Pages: XVI, 452
Number of Illustrations: 56 b/w illustrations, 4 illustrations in colour
Topics: Oncology